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Database: UniProt
Entry: P0CQ86
LinkDB: P0CQ86
Original site: P0CQ86 
ID   DBP5_CRYNJ              Reviewed;         546 AA.
AC   P0CQ86; Q55NB1; Q5KBP4; Q5KBP5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   16-OCT-2019, entry version 35.
DE   RecName: Full=ATP-dependent RNA helicase DBP5;
DE            EC=3.6.4.13;
GN   Name=DBP5; OrderedLocusNames=CNI01880;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 /
OS   ATCC MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J.,
RA   D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J.,
RA   Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I.,
RA   Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E.,
RA   Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L.,
RA   Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A.,
RA   Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R.,
RA   Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W.,
RA   Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen
RT   Cryptococcus neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: ATP-dependent RNA helicase associated with the nuclear
CC       pore complex and essential for mRNA export from the nucleus. May
CC       participate in a terminal step of mRNA export through the removal
CC       of proteins that accompany mRNA through the nucleopore complex.
CC       May also be involved in early transcription (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with the nuclear pore complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nuclear
CC       pore complex. Nucleus membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Note=Nuclear pore complex cytoplasmic fibrils. {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX19/DBP5
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW45355.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AE017349; AAW45356.1; -; Genomic_DNA.
DR   EMBL; AE017349; AAW45355.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_572662.1; XM_572662.1.
DR   RefSeq; XP_572663.1; XM_572663.1.
DR   SMR; P0CQ86; -.
DR   STRING; 5207.AAW45355; -.
DR   PaxDb; P0CQ86; -.
DR   GeneID; 3259615; -.
DR   KEGG; cne:CNI01880; -.
DR   EuPathDB; FungiDB:CNI01880; -.
DR   eggNOG; KOG0332; Eukaryota.
DR   eggNOG; ENOG410XRGX; LUCA.
DR   InParanoid; P0CQ86; -.
DR   KO; K18655; -.
DR   OrthoDB; 608788at2759; -.
DR   Proteomes; UP000002149; Chromosome 9.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleotide-binding;
KW   Nucleus; Protein transport; Reference proteome; RNA-binding;
KW   Translocation; Transport.
FT   CHAIN         1    546       ATP-dependent RNA helicase DBP5.
FT                                /FTId=PRO_0000232221.
FT   DOMAIN      181    350       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      361    531       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     194    201       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       148    176       Q motif.
FT   MOTIF       297    300       DEAD box.
SQ   SEQUENCE   546 AA;  59443 MW;  A1339D5ECBFD5FB1 CRC64;
     MSDAQAPPAS TSWADMVDED EKQKQEQNMS NQNDGWGETA TETSAPAPPP ASAPVSSSNN
     DGWGEPAPSA PADNGWADAG ASNGGSGANN NDGWFDAPVP PSSQPPKKEA SDIQLQDDTE
     GLITNTFQVE VKLADLQGDP NSPLYSVQSF KELNLHEDLM KGIIAAGFQK PSKIQEKALP
     LLLSNPPRNL IGQSQSGTGK TAAFTLNMLS RVDPTIPTPQ AICIAPSREL ARQIQEVIDQ
     IGQFTQVGTF LAIPGSWSRN SRIDKQILIG TPGTLVDMLM RGSRILDPRM IRVLVLDEAD
     ELIAQQGLGE QTFRIKQLLP PNVQNVLFSA TFNDDVQEFA DRFAPEANKI FLRKEDITVD
     AIRQLYLECD SEDQKYEALS ALYDCLVIGQ SIVFCKRKVT ADHIAERLIS EGHAVASLHG
     DKLSQERDAI LDGFRNGETK VLITTNVIAR GIDIPAVNMV VNYDVPDLGP GGNGPDIETY
     IHRIGRTGRF GRKGCSVIFT HDYRSKSDVE RIMNTLGKPM KKIDARSTTD IEQLEKALKL
     AMKGPA
//
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