GenomeNet

Database: UniProt
Entry: P0CQ93
LinkDB: P0CQ93
Original site: P0CQ93 
ID   DRS1_CRYNB              Reviewed;         808 AA.
AC   P0CQ93; Q55TT3; Q5KIK3;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   31-JUL-2019, entry version 35.
DE   RecName: Full=ATP-dependent RNA helicase DRS1;
DE            EC=3.6.4.13;
GN   Name=DRS1; OrderedLocusNames=CNBD3700;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J.,
RA   D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J.,
RA   Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I.,
RA   Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E.,
RA   Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L.,
RA   Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A.,
RA   Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R.,
RA   Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W.,
RA   Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen
RT   Cryptococcus neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in ribosome assembly.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with pre-ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX27/DRS1
CC       subfamily. {ECO:0000305}.
DR   EMBL; AAEY01000020; EAL21316.1; -; Genomic_DNA.
DR   RefSeq; XP_775963.1; XM_770870.1.
DR   SMR; P0CQ93; -.
DR   PRIDE; P0CQ93; -.
DR   EnsemblFungi; AAW43165; AAW43165; CND02650.
DR   EnsemblFungi; EAL21316; EAL21316; CNBD3700.
DR   GeneID; 4935759; -.
DR   KEGG; cnb:CNBD3700; -.
DR   EuPathDB; FungiDB:CNBD3700; -.
DR   eggNOG; KOG0338; Eukaryota.
DR   eggNOG; COG0513; LUCA.
DR   HOGENOM; HOG000265456; -.
DR   KO; K13181; -.
DR   Proteomes; UP000001435; Chromosome 4.
DR   Proteomes; UP000001435; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Ribosome biogenesis; RNA-binding.
FT   CHAIN         1    808       ATP-dependent RNA helicase DRS1.
FT                                /FTId=PRO_0000410257.
FT   DOMAIN      253    431       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      442    621       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     266    273       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COILED      575    645       {ECO:0000255}.
FT   MOTIF       222    250       Q motif.
FT   MOTIF       379    382       DEAD box.
FT   COMPBIAS    107    201       Glu-rich.
SQ   SEQUENCE   808 AA;  89326 MW;  5787CB4324D3D8BB CRC64;
     MIIHSSSSNS KKEYTMADDF ITTIDSDDEV SNYGEPSALP KIKDDELDPD FQFDLGGGRS
     EGLDLWGGDE VQGVKKGNEP INVDDIIERK RGKPIRAFKD RKRKRDEDAT SEDDLEEDEE
     EEGDSNDDSD AAKSGDSEED EMDVDMSEGD GDEEDENEIE SLKREDESDE EEEEEEDDYD
     EEGENEVVDS DSESEEETAA EIARKDAFFS SDPTTTDPTL PSSFTAMNLS RPLLRALTSL
     QFTAPTPIQA RAIPLALLGR DILGSAVTGS GKTAAFMVPI LERLCYRDRG KGGAACRVLV
     LCPTRELAVQ CEAVGKALAE KGGLDVRFAL LVGGLSLNAQ AHTLRTLPDI LIATPGRLID
     HLTNTPSFTL SALDVLVIDE ADRMLEAGFT DELEEIIKAC PRSRQTMLFS ATMTDSVDEL
     VKLSLDKPIR VFVDPKRNTA RGLTQEFVRI RSDDSRSPSL LALCKRTIRE KCIIFFRSKA
     LAHQMRIVFG LFGLKAAELH GNLTQEQRLQ ALNDFKAGTV DYLLATDLAS RGLDIKGVET
     VINYDMPGQL AQYTHRVGRT ARAGRKGRSV SLVGEADRKM LKAAIKQAEA DQVRHRIIPS
     EAVTAMKEKL EEFKDDIQEI LKEEKEEKLL RQADMEIKKG QNMVEHEAEI FSRPARTWFQ
     SGKEKQASKS AGKDAYVGSF PSTGKSAEKE KEKLKRGKYD GLSRRLKRRK MAIEEDAADA
     AAARKTEMGI RAAKKNALPK KITEPQPRLE KAGKGKDKKK GKARRVTGGK GSAFDSEGKK
     SHEGMRAKPA KVNLEKGKKK GGKGKGRK
//
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