ID JIP5_CRYNJ Reviewed; 374 AA.
AC P0CS40; Q55ZY2; Q5KP90;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=WD repeat-containing protein JIP5;
GN Name=JIP5; OrderedLocusNames=CNA03780;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}.
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DR EMBL; AE017341; AAW40894.1; -; Genomic_DNA.
DR RefSeq; XP_566713.1; XM_566713.1.
DR AlphaFoldDB; P0CS40; -.
DR SMR; P0CS40; -.
DR STRING; 214684.P0CS40; -.
DR PaxDb; 214684-P0CS40; -.
DR eggNOG; KOG2444; Eukaryota.
DR HOGENOM; CLU_035848_2_1_1; -.
DR InParanoid; P0CS40; -.
DR OMA; MFENLCT; -.
DR Proteomes; UP000002149; Chromosome 1.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR017422; WDR55.
DR PANTHER; PTHR44019; WD REPEAT-CONTAINING PROTEIN 55; 1.
DR PANTHER; PTHR44019:SF20; WD REPEAT-CONTAINING PROTEIN 55; 1.
DR Pfam; PF00400; WD40; 2.
DR PIRSF; PIRSF038169; WD_repeat_p55; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..374
FT /note="WD repeat-containing protein JIP5"
FT /id="PRO_0000333557"
FT REPEAT 21..61
FT /note="WD 1"
FT REPEAT 68..107
FT /note="WD 2"
FT REPEAT 120..158
FT /note="WD 3"
FT REPEAT 161..200
FT /note="WD 4"
FT REPEAT 205..244
FT /note="WD 5"
FT REPEAT 249..287
FT /note="WD 6"
FT REPEAT 290..330
FT /note="WD 7"
FT REGION 325..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..341
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 374 AA; 41505 MW; 1D1F83B5738E2EB1 CRC64;
MPDIKLKNQA SLCASTRLFL AYTSIKPFDV AFHPKEPVVF SSLLTGQVCA WSYDDATGET
SSSWSVRPSK RTARALSIEE NGDEIWMGGK SGSLLCALTP PKVIQLSTRD GSMTRERDSA
HECPINRVYC VNRNLVATGD DDGVIKLWDP RQADSIRTYS QHFDYISDFT YFDDKRQLVA
TSGDGHLSVI DIRSNKSTPL TVSEDQEDEL LSIVPIKGGQ KAIVGSGLGI LSVWNRQMGW
ADSVDRIPGH PASIDAIVAL TPDIIATGSE DGMIRVIQVL PHKFLGVVAT HEEFPVERIR
LDRNNKWLGS VSHDECLKLT DVEDLFEDSD EDDEMEEDEP DSDEEKSKKK KKDNGMKDMS
RGQAENDGSF FADL
//
