GenomeNet

Database: UniProt
Entry: P0DJB5
LinkDB: P0DJB5
Original site: P0DJB5 
ID   CUX4_CONCL              Reviewed;          32 AA.
AC   P0DJB5;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   12-SEP-2018, entry version 11.
DE   RecName: Full=Conotoxin Cltx-4;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   PROTEIN SEQUENCE, HYDROXYLATION AT PRO-2; PRO-24; PRO-28 AND PRO-30,
RP   AND AMIDATION AT SER-32.
RC   TISSUE=Venom;
RX   PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA   Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA   Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A.,
RA   Corneli P.S., Olivera B.M.;
RT   "Evolution of Conus peptide toxins: analysis of Conus californicus
RT   Reeve, 1844.";
RL   Mol. Phylogenet. Evol. 56:1-12(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is CCC-C-CC-C-C.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hydroxylation;
KW   Neurotoxin; Secreted; Toxin.
FT   PEPTIDE       1     32       Conotoxin Cltx-4.
FT                                /FTId=PRO_0000415051.
FT   MOD_RES       2      2       4-hydroxyproline.
FT                                {ECO:0000305|PubMed:20363338}.
FT   MOD_RES      24     24       4-hydroxyproline.
FT                                {ECO:0000305|PubMed:20363338}.
FT   MOD_RES      28     28       4-hydroxyproline.
FT                                {ECO:0000305|PubMed:20363338}.
FT   MOD_RES      30     30       4-hydroxyproline.
FT                                {ECO:0000305|PubMed:20363338}.
FT   MOD_RES      32     32       Serine amide.
FT                                {ECO:0000305|PubMed:20363338}.
SQ   SEQUENCE   32 AA;  3490 MW;  9FD9F76EEA2BB7FA CRC64;
     RPKCCCVCGV VGRKCCSTWD KCHPVHLPCP SS
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