ID HTR4_HALSA Reviewed; 778 AA.
AC P0DMI4; Q48319; Q9HR92;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Transducer protein Htr4;
DE AltName: Full=HTP VI;
GN Name=htr4; Synonyms=htpVI; OrderedLocusNames=VNG_0806G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium; Halobacterium salinarum NRC-34001.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC -!- FUNCTION: Potentially involved in chemo- or phototactic signal
CC transduction. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- PTM: Methylated by CheR. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC family. {ECO:0000305}.
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DR EMBL; AE004437; AAG19266.1; -; Genomic_DNA.
DR PIR; F84237; F84237.
DR RefSeq; WP_010902562.1; NC_002607.1.
DR AlphaFoldDB; P0DMI4; -.
DR SMR; P0DMI4; -.
DR STRING; 64091.VNG_0806G; -.
DR PaxDb; 64091-VNG_0806G; -.
DR GeneID; 68693648; -.
DR KEGG; hal:VNG_0806G; -.
DR PATRIC; fig|64091.14.peg.618; -.
DR HOGENOM; CLU_000445_107_19_2; -.
DR InParanoid; P0DMI4; -.
DR OrthoDB; 8523at2157; -.
DR PhylomeDB; P0DMI4; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd11386; MCP_signal; 1.
DR Gene3D; 6.10.250.1910; -; 1.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR004089; MCPsignal_dom.
DR PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00015; MCPsignal; 1.
DR PRINTS; PR00260; CHEMTRNSDUCR.
DR SMART; SM00304; HAMP; 2.
DR SMART; SM00283; MA; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR PROSITE; PS50885; HAMP; 2.
PE 3: Inferred from homology;
KW Cell membrane; Chemotaxis; Membrane; Methylation; Reference proteome;
KW Repeat; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..778
FT /note="Transducer protein Htr4"
FT /id="PRO_0000110553"
FT TOPO_DOM 1..26
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..296
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..778
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 318..370
FT /note="HAMP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT DOMAIN 412..465
FT /note="HAMP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT DOMAIN 484..720
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT REGION 376..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 522
FT /note="Glutamate methyl ester (Glu)"
FT /evidence="ECO:0000250"
FT MOD_RES 739
FT /note="Glutamate methyl ester (Glu)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 778 AA; 82077 MW; D752278727A4FA79 CRC64;
MSIRSFAHRI LRRALPGFVR RSYLAKFGVA LLAVVVCISA AGGVMYLNTS EHLQQSSRTE
LKKAAELSSS AVDNWHDERT NNARMLAQYG VFDNDNATEV QQFFTDEQHH LPSDVRDIHY
VSLTDARVIT STDAGLRNAS FGSEAAPWSR QQLTPGDDGV FVSQPYVNDG ITEVAYVARV
SSTPGRRTAV VMTASLAAIS SSFWDPTPHS FTQLVDGTGS VIADDSKRAT RQPYVENATS
PIVGARAVGF QPAAQAAKEM DQAHETAYAP VDGTPWVVTL HVPTSEAYGL ASNMAENVLL
ILGIALAGLV FIALTLGRGT VRALNDLEAK AAALERGEYD TDLDVARVDE LGRLFEAFAS
LRDTVQARIR DANEQQVDAE AARSEAEAAQ ADAEAAQAEA EAAREESEAQ ARRLETTAEA
FSETMRAYAA GDLTVRLDAD VEQAAMADIA AAFNEMAADM EATIADVVAF ADEVATASTD
ASDSAAAVEQ TGRDVSDAVG RIRDRAADQR DQLEAVASET DEMSATIEEV AASADQVAET
SQRAAALGDD GQAAAQDAVA QLEEIEDETQ AAATAVDDLE AKMSEIETIV AAITDIAEQT
NMLALNANIE AARADQDGDG FAVVADEVKD LADESKASAA EIEALVAEVR AQTETSVAAM
DRIQERVSDG VETVSETERS LSEIAGRIAE ADTGVQEISN AMDDQAASVS DVTTAVGDVA
ALGEETATEA ESTADAAAEQ ATTLSDVAAQ TETLAEHAVA LREHAAQFEV AADNEPGA
//
