ID HV43D_HUMAN Reviewed; 118 AA.
AC P0DP04;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Immunoglobulin heavy variable 3-43D {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.3};
DE Flags: Precursor;
GN Name=IGHV3-43D {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (IMGT ALLELE IGHV3-43D*01).
RX PubMed=23541343; DOI=10.1016/j.ajhg.2013.03.004;
RA Watson C.T., Steinberg K.M., Huddleston J., Warren R.L., Malig M.,
RA Schein J., Willsey A.J., Joy J.B., Scott J.K., Graves T.A., Wilson R.K.,
RA Holt R.A., Eichler E.E., Breden F.;
RT "Complete haplotype sequence of the human immunoglobulin heavy-chain
RT variable, diversity, and joining genes and characterization of allelic and
RT copy-number variation.";
RL Am. J. Hum. Genet. 92:530-546(2013).
RN [2]
RP NOMENCLATURE.
RX PubMed=11340299; DOI=10.1159/000049189;
RA Lefranc M.P.;
RT "Nomenclature of the human immunoglobulin heavy (IGH) genes.";
RL Exp. Clin. Immunogenet. 18:100-116(2001).
RN [3]
RP NOMENCLATURE.
RA Lefranc M.P., Lefranc G.;
RT "The Immunoglobulin FactsBook.";
RL (In) Lefranc M.P., Lefranc G. (eds.);
RL The Immunoglobulin FactsBook., pp.1-458, Academic Press, London. (2001).
RN [4]
RP REVIEW ON SOMATIC HYPERMUTATION.
RX PubMed=17576170; DOI=10.1146/annurev.genet.41.110306.130340;
RA Teng G., Papavasiliou F.N.;
RT "Immunoglobulin somatic hypermutation.";
RL Annu. Rev. Genet. 41:107-120(2007).
RN [5]
RP REVIEW ON IMMUNOGLOBULINS.
RX PubMed=20176268; DOI=10.1016/j.jaci.2009.09.046;
RA Schroeder H.W. Jr., Cavacini L.;
RT "Structure and function of immunoglobulins.";
RL J. Allergy Clin. Immunol. 125:S41-S52(2010).
RN [6]
RP REVIEW ON FUNCTION.
RX PubMed=22158414; DOI=10.1038/nri3128;
RA McHeyzer-Williams M., Okitsu S., Wang N., McHeyzer-Williams L.;
RT "Molecular programming of B cell memory.";
RL Nat. Rev. Immunol. 12:24-34(2012).
RN [7]
RP NOMENCLATURE.
RX PubMed=24600447; DOI=10.3389/fimmu.2014.00022;
RA Lefranc M.P.;
RT "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise
RT of Immunoinformatics.";
RL Front. Immunol. 5:22-22(2014).
CC -!- FUNCTION: V region of the variable domain of immunoglobulin heavy
CC chains that participates in the antigen recognition (PubMed:24600447).
CC Immunoglobulins, also known as antibodies, are membrane-bound or
CC secreted glycoproteins produced by B lymphocytes. In the recognition
CC phase of humoral immunity, the membrane-bound immunoglobulins serve as
CC receptors which, upon binding of a specific antigen, trigger the clonal
CC expansion and differentiation of B lymphocytes into immunoglobulins-
CC secreting plasma cells. Secreted immunoglobulins mediate the effector
CC phase of humoral immunity, which results in the elimination of bound
CC antigens (PubMed:22158414, PubMed:20176268). The antigen binding site
CC is formed by the variable domain of one heavy chain, together with that
CC of its associated light chain. Thus, each immunoglobulin has two
CC antigen binding sites with remarkable affinity for a particular
CC antigen. The variable domains are assembled by a process called V-(D)-J
CC rearrangement and can then be subjected to somatic hypermutations
CC which, after exposure to antigen and selection, allow affinity
CC maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
CC {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268,
CC ECO:0000303|PubMed:22158414, ECO:0000303|PubMed:24600447}.
CC -!- SUBUNIT: Immunoglobulins are composed of two identical heavy chains and
CC two identical light chains; disulfide-linked.
CC {ECO:0000303|PubMed:20176268}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268,
CC ECO:0000303|PubMed:22158414}. Cell membrane
CC {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
CC -!- POLYMORPHISM: There are several alleles. The sequence shown is that of
CC IMGT allele IGHV3-43D*01. {ECO:0000305}.
CC -!- CAUTION: For examples of full-length immunoglobulin heavy chains (of
CC different isotypes) see AC P0DOX2, AC P0DOX3, AC P0DOX4, AC P0DOX5 and
CC AC P0DOX6. {ECO:0000305}.
CC -!- CAUTION: Watson et al. identified this gene on chromosome 14. However,
CC it is not currently present on the reference genome assembly
CC (GRCh38/hg38). {ECO:0000305|PubMed:23541343}.
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DR EMBL; KC713950; AGI96768.1; -; Genomic_DNA.
DR AlphaFoldDB; P0DP04; -.
DR EMDB; EMD-27438; -.
DR EMDB; EMD-27439; -.
DR EMDB; EMD-32038; -.
DR EMDB; EMD-32039; -.
DR EMDB; EMD-34126; -.
DR EMDB; EMD-34127; -.
DR EMDB; EMD-34132; -.
DR EMDB; EMD-34133; -.
DR EMDB; EMD-34134; -.
DR EMDB; EMD-34135; -.
DR SMR; P0DP04; -.
DR STRING; 9606.ENSP00000481152; -.
DR IMGT_GENE-DB; IGHV3-43D; -.
DR BioMuta; HGNC:50322; -.
DR jPOST; P0DP04; -.
DR MassIVE; P0DP04; -.
DR PaxDb; 9606-ENSP00000481152; -.
DR PeptideAtlas; P0DP04; -.
DR GeneCards; IGHV3-43D; -.
DR HGNC; HGNC:50322; IGHV3-43D.
DR neXtProt; NX_P0DP04; -.
DR eggNOG; ENOG502TE7T; Eukaryota.
DR InParanoid; P0DP04; -.
DR Pharos; P0DP04; Tdark.
DR PRO; PR:P0DP04; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0DP04; Protein.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0016064; P:immunoglobulin mediated immune response; IBA:GO_Central.
DR CDD; cd04981; IgV_H; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR23266; IMMUNOGLOBULIN HEAVY CHAIN; 1.
DR PANTHER; PTHR23266:SF236; IMMUNOGLOBULIN HEAVY VARIABLE 3-43-RELATED; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Adaptive immunity; Cell membrane; Disulfide bond; Immunity; Immunoglobulin;
KW Immunoglobulin domain; Membrane; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..118
FT /note="Immunoglobulin heavy variable 3-43D"
FT /evidence="ECO:0000255"
FT /id="PRO_0000439569"
FT DOMAIN 20..>118
FT /note="Ig-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 41..115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 118
SQ SEQUENCE 118 AA; 13017 MW; 658C9C227D9A48F1 CRC64;
MEFGLSWVFL VAILKGVQCE VQLVESGGVV VQPGGSLRLS CAASGFTFDD YAMHWVRQAP
GKGLEWVSLI SWDGGSTYYA DSVKGRFTIS RDNSKNSLYL QMNSLRAEDT ALYYCAKD
//
