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Database: UniProt
Entry: P0DPD5
LinkDB: P0DPD5
Original site: P0DPD5 
ID   ZN723_HUMAN             Reviewed;         513 AA.
AC   P0DPD5;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Zinc finger protein 723 {ECO:0000305};
GN   Name=ZNF723 {ECO:0000312|HGNC:HGNC:32286};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AC008626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS86735.1; -.
DR   AlphaFoldDB; P0DPD5; -.
DR   SMR; P0DPD5; -.
DR   STRING; 9606.ENSP00000494306; -.
DR   iPTMnet; P0DPD5; -.
DR   PhosphoSitePlus; P0DPD5; -.
DR   jPOST; P0DPD5; -.
DR   MassIVE; P0DPD5; -.
DR   PeptideAtlas; P0DPD5; -.
DR   Ensembl; ENST00000600766.3; ENSP00000494306.1; ENSG00000268696.3.
DR   MANE-Select; ENST00000600766.3; ENSP00000494306.1; NM_001349726.2; NP_001336655.1.
DR   AGR; HGNC:32286; -.
DR   GeneCards; ZNF723; -.
DR   HGNC; HGNC:32286; ZNF723.
DR   HPA; ENSG00000268696; Tissue enriched (testis).
DR   neXtProt; NX_P0DPD5; -.
DR   OpenTargets; ENSG00000268696; -.
DR   VEuPathDB; HostDB:ENSG00000268696; -.
DR   GeneTree; ENSGT01100000263507; -.
DR   InParanoid; P0DPD5; -.
DR   OMA; FKIRTHL; -.
DR   OrthoDB; 3120079at2759; -.
DR   Pharos; P0DPD5; Tdark.
DR   PRO; PR:P0DPD5; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000268696; Expressed in primordial germ cell in gonad and 17 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 12.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24394; ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR24394:SF45; ZINC FINGER PROTEIN 771; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   Pfam; PF13912; zf-C2H2_6; 1.
DR   Pfam; PF13465; zf-H2C2_2; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 12.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..513
FT                   /note="Zinc finger protein 723"
FT                   /id="PRO_0000442922"
FT   DOMAIN          4..75
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         173..195
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         201..223
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         229..251
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         257..279
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         285..307
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         313..335
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         341..363
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         369..391
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         397..419
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         425..447
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         453..475
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         481..503
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   513 AA;  59152 MW;  3C291F2FB42CFDE8 CRC64;
     MGPLTFTDVA IKFSLEEWQF LDTAQQNLYR DVMLENYRNL VFLGVGVSKP DLITCLEQGK
     EPWNMKRHKM VAKPPVVCSH FAQDLWPEQG IKDSFQKVIL RSYGKYGHDN LQLRKGCESV
     DECKMHKGGY DELKQCLTTT PSKIFQCDKY VKVFHKFSSS NSQKIRHTGN NSFKCKECGK
     SFCMLSHLTK HERNHTRVNC YKCEECGKAF SVPSKLNNHK RIHTGEKPYK CEECGKAFNV
     SSSLNNHKRI HTGEKPYKCE ECGKTFNMFS SLNNHKRIHT GEKPYKCKEC GKAFNVFSSL
     NNHKRIHTGE KPYKCEECGK AFNQPSHLAT HKRIHTGEKL YKCEECGKAF SQSSHITTHK
     RIHTGEKPYK CEECGKAFKV SVHLTTHKRI HTGEKPYKCE ECGKAFNQSS ALTTHKIIHT
     GERPYKCKQC GKGFSQSSTL TKHKIIHTKE KPYKCEECGK AFNQYSTLNK HKIIHAREKP
     YKCEECGKAF NKSSILNRHK IIHTKEKSQT LKM
//
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