ID NPY42_HUMAN Reviewed; 375 AA.
AC P0DQD5;
DT 10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Neuropeptide Y receptor type 4-2 {ECO:0000305};
GN Name=NPY4R2 {ECO:0000312|HGNC:HGNC:52383};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
CC -!- FUNCTION: G protein-coupled receptor for PPY/pancreatic polypeptide/PP,
CC NPY/neuropeptide Y and PYY/peptide YY that is negatively coupled to
CC cAMP. The rank order of affinity for these polypeptides and their
CC derivatives is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY >
CC PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP
CC (13-36) > PP (31-36) > NPY free acid. {ECO:0000250|UniProtKB:P50391}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50391};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AC245041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS81459.1; -.
DR RefSeq; NP_001265724.1; NM_001278795.1.
DR RefSeq; XP_005277701.1; XM_005277644.3.
DR RefSeq; XP_006717608.1; XM_006717545.3.
DR RefSeq; XP_011537416.1; XM_011539114.2.
DR RefSeq; XP_011537417.1; XM_011539115.2.
DR RefSeq; XP_011547675.1; XM_011549373.2.
DR RefSeq; XP_011547676.1; XM_011549374.2.
DR RefSeq; XP_011547677.1; XM_011549375.2.
DR RefSeq; XP_011547678.1; XM_011549376.2.
DR RefSeq; XP_016854962.1; XM_016999473.1.
DR RefSeq; XP_016854963.1; XM_016999474.1.
DR RefSeq; XP_016870952.1; XM_017015463.1.
DR RefSeq; XP_016870953.1; XM_017015464.1.
DR AlphaFoldDB; P0DQD5; -.
DR SMR; P0DQD5; -.
DR STRING; 9606.ENSP00000490174; -.
DR GlyCosmos; P0DQD5; 4 sites, No reported glycans.
DR GlyGen; P0DQD5; 4 sites.
DR MassIVE; P0DQD5; -.
DR PaxDb; 9606-ENSP00000363431; -.
DR PeptideAtlas; P0DQD5; -.
DR Ensembl; ENST00000576178.7; ENSP00000490174.1; ENSG00000264717.6.
DR Ensembl; ENST00000613306.1; ENSP00000489924.1; ENSG00000264717.6.
DR Ensembl; ENST00000671787.1; ENSP00000500673.1; ENSG00000288157.1.
DR Ensembl; ENST00000671991.1; ENSP00000499999.1; ENSG00000288157.1.
DR GeneID; 100996758; -.
DR KEGG; hsa:100996758; -.
DR MANE-Select; ENST00000576178.7; ENSP00000490174.1; NM_001395253.1; NP_001382182.1.
DR AGR; HGNC:52383; -.
DR CTD; 100996758; -.
DR DisGeNET; 100996758; -.
DR GeneCards; NPY4R2; -.
DR HGNC; HGNC:52383; NPY4R2.
DR HPA; ENSG00000264717; Tissue enhanced (intestine).
DR neXtProt; NX_P0DQD5; -.
DR VEuPathDB; HostDB:ENSG00000264717; -.
DR GeneTree; ENSGT00940000161927; -.
DR InParanoid; P0DQD5; -.
DR OMA; FTVVYTM; -.
DR OrthoDB; 2995026at2759; -.
DR PRO; PR:P0DQD5; -.
DR Proteomes; UP000005640; Chromosome 10.
DR Bgee; ENSG00000264717; Expressed in colonic epithelium and 43 other cell types or tissues.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0001602; F:pancreatic polypeptide receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd15397; 7tmA_NPY4R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001933; NPY4_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR PANTHER; PTHR24235; NEUROPEPTIDE Y RECEPTOR; 1.
DR PANTHER; PTHR24235:SF25; NEUROPEPTIDE Y RECEPTOR TYPE 4-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01015; NRPEPTIDEY4R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..375
FT /note="Neuropeptide Y receptor type 4-2"
FT /id="PRO_0000446660"
FT TOPO_DOM 1..39
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 40..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 88..108
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..116
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..212
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 264..284
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..301
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 302..322
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT LIPID 340
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..201
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 375 AA; 42195 MW; 0081DBA51436EE22 CRC64;
MNTSHLLALL LPKSPQGENR SKPLGTPYNF SEHCQDSVDV MVFIVTSYSI ETVVGVLGNL
CLMCVTVRQK EKANVTNLLI ANLAFSDFLM CLLCQPLTAV YTIMDYWIFG ETLCKMSAFI
QCMSVTVSIL SLVLVALERH QLIINPTGWK PSISQAYLGI VLIWVIACVL SLPFLANSIL
ENVFHKNHSK ALEFLADKVV CTESWPLAHH RTIYTTFLLL FQYCLPLGFI LVCYARIYRR
LQRQGRVFHK GTYSLRAGHM KQVNVVLVVM VVAFAVLWLP LHVFNSLEDW HHEAIPICHG
NLIFLVCHLL AMASTCVNPF IYGFLNTNFK KEIKALVLTC QQSAPLEESE HLPLSTVHTE
VSKGSLRLSG RSNPI
//
