GenomeNet

Database: UniProt
Entry: P10041
LinkDB: P10041
Original site: P10041 
ID   DL_DROME                Reviewed;         833 AA.
AC   P10041; Q6T3F7; Q6T3G1; Q6T3G7; Q6T3G8; Q6T3H0; Q6T3H3; Q6T3I3;
AC   Q6T3I5; Q6T3I7; Q6T3J1; Q6T3J2; Q6T3J3; Q6T3J4; Q6T3K0; Q6T3K1;
AC   Q6T3K9; Q6T3L5; Q6T3L7; Q6T3L9; Q6T3M2; Q6T3M4; Q6T3M7; Q6T3N1;
AC   Q6T3N3; Q6T3N5; Q6T3N7; Q6T4M9; Q6T4N0; Q6T4N1; Q6T4N2; Q6T4N3;
AC   Q6T4N4; Q6T4N6; Q95RM9; Q99108; Q9VDY2;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   13-FEB-2019, entry version 205.
DE   RecName: Full=Neurogenic locus protein delta;
DE   Flags: Precursor;
GN   Name=Dl; ORFNames=CG3619;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND VARIANTS ALA-652 AND MET-662.
RC   TISSUE=Embryo;
RX   PubMed=16453806;
RA   Vaessin H., Bremer K.A., Knust E., Campos-Ortega J.A.;
RT   "The neurogenic gene Delta of Drosophila melanogaster is expressed in
RT   neurogenic territories and encodes a putative transmembrane protein
RT   with EGF-like repeats.";
RL   EMBO J. 6:3431-3440(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-812.
RC   STRAIN=Oregon-R; TISSUE=Embryo;
RX   PubMed=3149249; DOI=10.1101/gad.2.12b.1723;
RA   Kopczynski C.C., Alton A.K., Fechtel K., Kooh P.J., Muskavitch M.A.T.;
RT   "Delta, a Drosophila neurogenic gene, is transcriptionally complex and
RT   encodes a protein related to blood coagulation factors and epidermal
RT   growth factor of vertebrates.";
RL   Genes Dev. 2:1723-1735(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NapaValley1, NapaValley10, NapaValley11, NapaValley12,
RC   NapaValley2, NapaValley3, NapaValley4, NapaValley5, NapaValley6,
RC   NapaValley7, NapaValley8, NapaValley9, nps_1, nps_13, nps_14, nps_15,
RC   nps_16, nps_17, nps_18, nps_19, nps_2, nps_20, nps_21, nps_23, nps_24,
RC   nps_25, nps_26, nps_27, nps_28, nps_29, nps_3, nps_30, nps_31, nps_32,
RC   nps_33, nps_34, nps_35, nps_36, nps_37, nps_38, nps_39, nps_4, nps_40,
RC   nps_41, nps_42, nps_43, nps_44, nps_45, nps_46, nps_47, nps_48,
RC   nps_49, nps_5, nps_50, nps_6, sonoma_002, sonoma_003, sonoma_004,
RC   sonoma_005, sonoma_006, sonoma_007, sonoma_008, sonoma_009,
RC   sonoma_010, sonoma_013, sonoma_014, sonoma_015, sonoma_016,
RC   sonoma_017, sonoma_019, sonoma_022, sonoma_023, sonoma_024,
RC   sonoma_031, sonoma_032, sonoma_033, sonoma_034, sonoma_036,
RC   sonoma_038, sonoma_039, sonoma_040, sonoma_045, sonoma_046,
RC   sonoma_048, sonoma_050, sonoma_051, sonoma_053, sonoma_054,
RC   sonoma_055, sonoma_058, sonoma_059, sonoma_061, sonoma_064,
RC   sonoma_073, sonoma_074, sonoma_081, sonoma_085, sonoma_086,
RC   sonoma_087, sonoma_094, sonoma_095, sonoma_097, sonoma_101,
RC   sonoma_106, sonoma_107, sonoma_111, sonoma_116, sonoma_117, and
RC   sonoma_119;
RX   PubMed=15020426; DOI=10.1534/genetics.166.1.291;
RA   Genissel A., Pastinen T., Dowell A., Mackay T.F.C., Long A.D.;
RT   "No evidence for an association between common nonsynonymous
RT   polymorphisms in delta and bristle number variation in natural and
RT   laboratory populations of Drosophila melanogaster.";
RL   Genetics 166:291-306(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W.,
RA   Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
RA   George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G.,
RA   Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S.,
RA   Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M.,
RA   Celniker S.E.;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-833.
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA   George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA   Rubin G.M., Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 422-621.
RC   TISSUE=Embryo;
RX   PubMed=3107986;
RA   Knust E., Dietrich U., Tepass U., Bremer K.A., Weigel D., Vaessin H.,
RA   Campos-Ortega J.A.;
RT   "EGF homologous sequences encoded in the genome of Drosophila
RT   melanogaster, and their relation to neurogenic genes.";
RL   EMBO J. 6:761-766(1987).
RN   [9]
RP   FUNCTION, AND INTERACTION WITH DL.
RX   PubMed=10935637; DOI=10.1038/35019075;
RA   Bruckner K., Perez L., Clausen H., Cohen S.;
RT   "Glycosyltransferase activity of Fringe modulates Notch-Delta
RT   interactions.";
RL   Nature 406:411-415(2000).
RN   [10]
RP   PATTERN OF TRANSCRIPTION, AND CHARACTERIZATION.
RX   PubMed=2128477;
RA   Haenlin M., Kramatschek B., Campos-Ortega J.A.;
RT   "The pattern of transcription of the neurogenic gene Delta of
RT   Drosophila melanogaster.";
RL   Development 110:905-914(1990).
RN   [11]
RP   INTERACTION WITH MIB, AND UBIQUITINATION.
RX   PubMed=15829515; DOI=10.1242/dev.01825;
RA   Lai E.C., Roegiers F., Qin X., Jan Y.N., Rubin G.M.;
RT   "The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by
RT   regulating the localization and activity of Serrate and Delta.";
RL   Development 132:2319-2332(2005).
RN   [12]
RP   UBIQUITINATION.
RX   PubMed=15760269; DOI=10.1371/journal.pbio.0030096;
RA   Le Borgne R., Remaud S., Hamel S., Schweisguth F.;
RT   "Two distinct E3 ubiquitin ligases have complementary functions in the
RT   regulation of delta and serrate signaling in Drosophila.";
RL   PLoS Biol. 3:688-696(2005).
RN   [13]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-666, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18327897; DOI=10.1021/pr700696a;
RA   Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT   "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL   J. Proteome Res. 7:1675-1682(2008).
CC   -!- FUNCTION: Acts as a ligand for Notch (N) receptor. Essential for
CC       proper differentiation of ectoderm. Dl is required for the correct
CC       separation of neural and epidermal cell lineages. Fringe (fng)
CC       acts in the Golgi to determine the type of O-linked fucose on the
CC       EGF modules in N, altering the ability of N to bind with Delta
CC       (Dl). O-fut1 also has a role in modulating the interaction.
CC       {ECO:0000269|PubMed:10935637}.
CC   -!- SUBUNIT: Interacts with N via the EGF repeats and the N EGF
CC       repeats. {ECO:0000269|PubMed:10935637,
CC       ECO:0000269|PubMed:15829515}.
CC   -!- INTERACTION:
CC       P07207:N; NbExp=2; IntAct=EBI-115346, EBI-103438;
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- TISSUE SPECIFICITY: Detected in all areas with neurogenic
CC       abilities, for example the neurogenic ectoderm and the primordia
CC       of the sense organs. Later expression is restricted to those cells
CC       that have adopted a neural fate. {ECO:0000269|PubMed:16453806}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       Expression is highest early in embryonic development (stage 5) and
CC       reduces to a low level during larval stages.
CC       {ECO:0000269|PubMed:16453806}.
CC   -!- PTM: Ubiquitinated by Mib, leading to its endocytosis and
CC       subsequent degradation. {ECO:0000269|PubMed:15760269,
CC       ECO:0000269|PubMed:15829515}.
CC   -!- MISCELLANEOUS: Separation of neuroblasts from the ectoderm into
CC       the inner part of embryo is one of the first steps of CNS
CC       development in insects, this process is under control of the
CC       neurogenic genes.
CC   -!- MISCELLANEOUS: Notch and Serrate may interact at the protein
CC       level, it is conceivable that the Serrate and Delta proteins may
CC       compete for binding with the Notch protein.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL28817.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
DR   EMBL; X06289; CAA29617.1; -; mRNA.
DR   EMBL; Y00222; CAA68369.1; -; mRNA.
DR   EMBL; AY437145; AAR21453.1; -; Genomic_DNA.
DR   EMBL; AY437140; AAR21453.1; JOINED; Genomic_DNA.
DR   EMBL; AY437141; AAR21453.1; JOINED; Genomic_DNA.
DR   EMBL; AY437142; AAR21453.1; JOINED; Genomic_DNA.
DR   EMBL; AY437143; AAR21453.1; JOINED; Genomic_DNA.
DR   EMBL; AY437144; AAR21453.1; JOINED; Genomic_DNA.
DR   EMBL; AY437151; AAR21454.1; -; Genomic_DNA.
DR   EMBL; AY437146; AAR21454.1; JOINED; Genomic_DNA.
DR   EMBL; AY437147; AAR21454.1; JOINED; Genomic_DNA.
DR   EMBL; AY437148; AAR21454.1; JOINED; Genomic_DNA.
DR   EMBL; AY437149; AAR21454.1; JOINED; Genomic_DNA.
DR   EMBL; AY437150; AAR21454.1; JOINED; Genomic_DNA.
DR   EMBL; AY437157; AAR21455.1; -; Genomic_DNA.
DR   EMBL; AY437152; AAR21455.1; JOINED; Genomic_DNA.
DR   EMBL; AY437153; AAR21455.1; JOINED; Genomic_DNA.
DR   EMBL; AY437154; AAR21455.1; JOINED; Genomic_DNA.
DR   EMBL; AY437155; AAR21455.1; JOINED; Genomic_DNA.
DR   EMBL; AY437156; AAR21455.1; JOINED; Genomic_DNA.
DR   EMBL; AY437163; AAR21456.1; -; Genomic_DNA.
DR   EMBL; AY437158; AAR21456.1; JOINED; Genomic_DNA.
DR   EMBL; AY437159; AAR21456.1; JOINED; Genomic_DNA.
DR   EMBL; AY437160; AAR21456.1; JOINED; Genomic_DNA.
DR   EMBL; AY437161; AAR21456.1; JOINED; Genomic_DNA.
DR   EMBL; AY437162; AAR21456.1; JOINED; Genomic_DNA.
DR   EMBL; AY437169; AAR21457.1; -; Genomic_DNA.
DR   EMBL; AY437164; AAR21457.1; JOINED; Genomic_DNA.
DR   EMBL; AY437165; AAR21457.1; JOINED; Genomic_DNA.
DR   EMBL; AY437166; AAR21457.1; JOINED; Genomic_DNA.
DR   EMBL; AY437167; AAR21457.1; JOINED; Genomic_DNA.
DR   EMBL; AY437168; AAR21457.1; JOINED; Genomic_DNA.
DR   EMBL; AY437175; AAR21458.1; -; Genomic_DNA.
DR   EMBL; AY437170; AAR21458.1; JOINED; Genomic_DNA.
DR   EMBL; AY437171; AAR21458.1; JOINED; Genomic_DNA.
DR   EMBL; AY437172; AAR21458.1; JOINED; Genomic_DNA.
DR   EMBL; AY437173; AAR21458.1; JOINED; Genomic_DNA.
DR   EMBL; AY437174; AAR21458.1; JOINED; Genomic_DNA.
DR   EMBL; AY437181; AAR21459.1; -; Genomic_DNA.
DR   EMBL; AY437176; AAR21459.1; JOINED; Genomic_DNA.
DR   EMBL; AY437177; AAR21459.1; JOINED; Genomic_DNA.
DR   EMBL; AY437178; AAR21459.1; JOINED; Genomic_DNA.
DR   EMBL; AY437179; AAR21459.1; JOINED; Genomic_DNA.
DR   EMBL; AY437180; AAR21459.1; JOINED; Genomic_DNA.
DR   EMBL; AY437187; AAR21460.1; -; Genomic_DNA.
DR   EMBL; AY437182; AAR21460.1; JOINED; Genomic_DNA.
DR   EMBL; AY437183; AAR21460.1; JOINED; Genomic_DNA.
DR   EMBL; AY437184; AAR21460.1; JOINED; Genomic_DNA.
DR   EMBL; AY437185; AAR21460.1; JOINED; Genomic_DNA.
DR   EMBL; AY437186; AAR21460.1; JOINED; Genomic_DNA.
DR   EMBL; AY437193; AAR21461.1; -; Genomic_DNA.
DR   EMBL; AY437188; AAR21461.1; JOINED; Genomic_DNA.
DR   EMBL; AY437189; AAR21461.1; JOINED; Genomic_DNA.
DR   EMBL; AY437190; AAR21461.1; JOINED; Genomic_DNA.
DR   EMBL; AY437191; AAR21461.1; JOINED; Genomic_DNA.
DR   EMBL; AY437192; AAR21461.1; JOINED; Genomic_DNA.
DR   EMBL; AY437199; AAR21462.1; -; Genomic_DNA.
DR   EMBL; AY437194; AAR21462.1; JOINED; Genomic_DNA.
DR   EMBL; AY437195; AAR21462.1; JOINED; Genomic_DNA.
DR   EMBL; AY437196; AAR21462.1; JOINED; Genomic_DNA.
DR   EMBL; AY437197; AAR21462.1; JOINED; Genomic_DNA.
DR   EMBL; AY437198; AAR21462.1; JOINED; Genomic_DNA.
DR   EMBL; AY437205; AAR21463.1; -; Genomic_DNA.
DR   EMBL; AY437200; AAR21463.1; JOINED; Genomic_DNA.
DR   EMBL; AY437201; AAR21463.1; JOINED; Genomic_DNA.
DR   EMBL; AY437202; AAR21463.1; JOINED; Genomic_DNA.
DR   EMBL; AY437203; AAR21463.1; JOINED; Genomic_DNA.
DR   EMBL; AY437204; AAR21463.1; JOINED; Genomic_DNA.
DR   EMBL; AY437211; AAR21464.1; -; Genomic_DNA.
DR   EMBL; AY437206; AAR21464.1; JOINED; Genomic_DNA.
DR   EMBL; AY437207; AAR21464.1; JOINED; Genomic_DNA.
DR   EMBL; AY437208; AAR21464.1; JOINED; Genomic_DNA.
DR   EMBL; AY437209; AAR21464.1; JOINED; Genomic_DNA.
DR   EMBL; AY437210; AAR21464.1; JOINED; Genomic_DNA.
DR   EMBL; AY437217; AAR21465.1; -; Genomic_DNA.
DR   EMBL; AY437212; AAR21465.1; JOINED; Genomic_DNA.
DR   EMBL; AY437213; AAR21465.1; JOINED; Genomic_DNA.
DR   EMBL; AY437214; AAR21465.1; JOINED; Genomic_DNA.
DR   EMBL; AY437215; AAR21465.1; JOINED; Genomic_DNA.
DR   EMBL; AY437216; AAR21465.1; JOINED; Genomic_DNA.
DR   EMBL; AY437223; AAR21466.1; -; Genomic_DNA.
DR   EMBL; AY437218; AAR21466.1; JOINED; Genomic_DNA.
DR   EMBL; AY437219; AAR21466.1; JOINED; Genomic_DNA.
DR   EMBL; AY437220; AAR21466.1; JOINED; Genomic_DNA.
DR   EMBL; AY437221; AAR21466.1; JOINED; Genomic_DNA.
DR   EMBL; AY437222; AAR21466.1; JOINED; Genomic_DNA.
DR   EMBL; AY437229; AAR21467.1; -; Genomic_DNA.
DR   EMBL; AY437224; AAR21467.1; JOINED; Genomic_DNA.
DR   EMBL; AY437225; AAR21467.1; JOINED; Genomic_DNA.
DR   EMBL; AY437226; AAR21467.1; JOINED; Genomic_DNA.
DR   EMBL; AY437227; AAR21467.1; JOINED; Genomic_DNA.
DR   EMBL; AY437228; AAR21467.1; JOINED; Genomic_DNA.
DR   EMBL; AY437235; AAR21468.1; -; Genomic_DNA.
DR   EMBL; AY437230; AAR21468.1; JOINED; Genomic_DNA.
DR   EMBL; AY437231; AAR21468.1; JOINED; Genomic_DNA.
DR   EMBL; AY437232; AAR21468.1; JOINED; Genomic_DNA.
DR   EMBL; AY437233; AAR21468.1; JOINED; Genomic_DNA.
DR   EMBL; AY437234; AAR21468.1; JOINED; Genomic_DNA.
DR   EMBL; AY438104; AAR21469.1; -; Genomic_DNA.
DR   EMBL; AY438105; AAR21470.1; -; Genomic_DNA.
DR   EMBL; AY438106; AAR21471.1; -; Genomic_DNA.
DR   EMBL; AY438107; AAR21472.1; -; Genomic_DNA.
DR   EMBL; AY438108; AAR21473.1; -; Genomic_DNA.
DR   EMBL; AY438109; AAR21474.1; -; Genomic_DNA.
DR   EMBL; AY438110; AAR21475.1; -; Genomic_DNA.
DR   EMBL; AY438111; AAR21476.1; -; Genomic_DNA.
DR   EMBL; AY438112; AAR21477.1; -; Genomic_DNA.
DR   EMBL; AY438113; AAR21478.1; -; Genomic_DNA.
DR   EMBL; AY438114; AAR21479.1; -; Genomic_DNA.
DR   EMBL; AY438115; AAR21480.1; -; Genomic_DNA.
DR   EMBL; AY438116; AAR21481.1; -; Genomic_DNA.
DR   EMBL; AY438117; AAR21482.1; -; Genomic_DNA.
DR   EMBL; AY438118; AAR21483.1; -; Genomic_DNA.
DR   EMBL; AY438119; AAR21484.1; -; Genomic_DNA.
DR   EMBL; AY438120; AAR21485.1; -; Genomic_DNA.
DR   EMBL; AY438121; AAR21486.1; -; Genomic_DNA.
DR   EMBL; AY438122; AAR21487.1; -; Genomic_DNA.
DR   EMBL; AY438123; AAR21488.1; -; Genomic_DNA.
DR   EMBL; AY438124; AAR21489.1; -; Genomic_DNA.
DR   EMBL; AY438125; AAR21490.1; -; Genomic_DNA.
DR   EMBL; AY438126; AAR21491.1; -; Genomic_DNA.
DR   EMBL; AY438127; AAR21492.1; -; Genomic_DNA.
DR   EMBL; AY438128; AAR21493.1; -; Genomic_DNA.
DR   EMBL; AY438129; AAR21494.1; -; Genomic_DNA.
DR   EMBL; AY438130; AAR21495.1; -; Genomic_DNA.
DR   EMBL; AY438131; AAR21496.1; -; Genomic_DNA.
DR   EMBL; AY438132; AAR21497.1; -; Genomic_DNA.
DR   EMBL; AY438133; AAR21498.1; -; Genomic_DNA.
DR   EMBL; AY438134; AAR21499.1; -; Genomic_DNA.
DR   EMBL; AY438135; AAR21500.1; -; Genomic_DNA.
DR   EMBL; AY438136; AAR21501.1; -; Genomic_DNA.
DR   EMBL; AY438137; AAR21502.1; -; Genomic_DNA.
DR   EMBL; AY438138; AAR21503.1; -; Genomic_DNA.
DR   EMBL; AY438139; AAR21504.1; -; Genomic_DNA.
DR   EMBL; AY438140; AAR21505.1; -; Genomic_DNA.
DR   EMBL; AY438141; AAR21506.1; -; Genomic_DNA.
DR   EMBL; AY438147; AAR09172.1; -; Genomic_DNA.
DR   EMBL; AY438148; AAR09173.1; -; Genomic_DNA.
DR   EMBL; AY438149; AAR09174.1; -; Genomic_DNA.
DR   EMBL; AY438150; AAR09175.1; -; Genomic_DNA.
DR   EMBL; AY438151; AAR09176.1; -; Genomic_DNA.
DR   EMBL; AY438152; AAR09177.1; -; Genomic_DNA.
DR   EMBL; AY438153; AAR09178.1; -; Genomic_DNA.
DR   EMBL; AY438154; AAR09179.1; -; Genomic_DNA.
DR   EMBL; AY438155; AAR09180.1; -; Genomic_DNA.
DR   EMBL; AY438156; AAR09181.1; -; Genomic_DNA.
DR   EMBL; AY438157; AAR09182.1; -; Genomic_DNA.
DR   EMBL; AY438158; AAR09183.1; -; Genomic_DNA.
DR   EMBL; AY438159; AAR09184.1; -; Genomic_DNA.
DR   EMBL; AY438160; AAR09185.1; -; Genomic_DNA.
DR   EMBL; AY438161; AAR09186.1; -; Genomic_DNA.
DR   EMBL; AY438162; AAR09187.1; -; Genomic_DNA.
DR   EMBL; AY438163; AAR09188.1; -; Genomic_DNA.
DR   EMBL; AY438164; AAR09189.1; -; Genomic_DNA.
DR   EMBL; AY438165; AAR09190.1; -; Genomic_DNA.
DR   EMBL; AY438166; AAR09191.1; -; Genomic_DNA.
DR   EMBL; AY438167; AAR09192.1; -; Genomic_DNA.
DR   EMBL; AY438168; AAR09193.1; -; Genomic_DNA.
DR   EMBL; AY438169; AAR09194.1; -; Genomic_DNA.
DR   EMBL; AY438170; AAR09195.1; -; Genomic_DNA.
DR   EMBL; AY438171; AAR09196.1; -; Genomic_DNA.
DR   EMBL; AY438172; AAR09197.1; -; Genomic_DNA.
DR   EMBL; AY438173; AAR09198.1; -; Genomic_DNA.
DR   EMBL; AY438174; AAR09199.1; -; Genomic_DNA.
DR   EMBL; AY438175; AAR09200.1; -; Genomic_DNA.
DR   EMBL; AY438176; AAR09201.1; -; Genomic_DNA.
DR   EMBL; AY438177; AAR09202.1; -; Genomic_DNA.
DR   EMBL; AY438178; AAR09203.1; -; Genomic_DNA.
DR   EMBL; AY438179; AAR09204.1; -; Genomic_DNA.
DR   EMBL; AY438180; AAR09205.1; -; Genomic_DNA.
DR   EMBL; AY438181; AAR09206.1; -; Genomic_DNA.
DR   EMBL; AY438182; AAR09207.1; -; Genomic_DNA.
DR   EMBL; AY438183; AAR09208.1; -; Genomic_DNA.
DR   EMBL; AY438184; AAR09209.1; -; Genomic_DNA.
DR   EMBL; AY438185; AAR09210.1; -; Genomic_DNA.
DR   EMBL; AY438186; AAR09211.1; -; Genomic_DNA.
DR   EMBL; AY438187; AAR09212.1; -; Genomic_DNA.
DR   EMBL; AY438188; AAR09213.1; -; Genomic_DNA.
DR   EMBL; AY438189; AAR09214.1; -; Genomic_DNA.
DR   EMBL; AY438190; AAR09215.1; -; Genomic_DNA.
DR   EMBL; AY438191; AAR09216.1; -; Genomic_DNA.
DR   EMBL; AY438192; AAR09217.1; -; Genomic_DNA.
DR   EMBL; AY438193; AAR09218.1; -; Genomic_DNA.
DR   EMBL; AY438194; AAR09219.1; -; Genomic_DNA.
DR   EMBL; AY438195; AAR09220.1; -; Genomic_DNA.
DR   EMBL; AY438196; AAR09221.1; -; Genomic_DNA.
DR   EMBL; AY438197; AAR09222.1; -; Genomic_DNA.
DR   EMBL; AY438198; AAR09223.1; -; Genomic_DNA.
DR   EMBL; AY438199; AAR09224.1; -; Genomic_DNA.
DR   EMBL; AY438200; AAR09225.1; -; Genomic_DNA.
DR   EMBL; AY438201; AAR09226.1; -; Genomic_DNA.
DR   EMBL; AY438202; AAR09227.1; -; Genomic_DNA.
DR   EMBL; BK004004; DAA02303.1; -; Genomic_DNA.
DR   EMBL; AE014297; AAF55657.1; -; Genomic_DNA.
DR   EMBL; BT003267; AAO25024.1; -; mRNA.
DR   EMBL; AY061269; AAL28817.1; ALT_INIT; mRNA.
DR   EMBL; X05140; CAA28786.1; -; mRNA.
DR   PIR; A31246; A31246.
DR   PIR; A43564; A43564.
DR   PIR; S00670; S00670.
DR   PIR; S19087; S19087.
DR   RefSeq; NP_001247193.1; NM_001260264.2.
DR   RefSeq; NP_477264.1; NM_057916.4.
DR   RefSeq; NP_732412.1; NM_169853.3.
DR   UniGene; Dm.7687; -.
DR   PDB; 4XIB; X-ray; 2.15 A; C=680-690.
DR   PDBsum; 4XIB; -.
DR   ProteinModelPortal; P10041; -.
DR   SMR; P10041; -.
DR   BioGrid; 67310; 127.
DR   DIP; DIP-22726N; -.
DR   IntAct; P10041; 2.
DR   STRING; 7227.FBpp0083153; -.
DR   iPTMnet; P10041; -.
DR   PaxDb; P10041; -.
DR   PRIDE; P10041; -.
DR   EnsemblMetazoa; FBtr0083739; FBpp0083153; FBgn0000463.
DR   EnsemblMetazoa; FBtr0083740; FBpp0083154; FBgn0000463.
DR   EnsemblMetazoa; FBtr0304658; FBpp0293200; FBgn0000463.
DR   GeneID; 42313; -.
DR   KEGG; dme:Dmel_CG3619; -.
DR   FlyBase; FBgn0000463; Dl.
DR   eggNOG; ENOG410IR7B; Eukaryota.
DR   eggNOG; ENOG410XUNS; LUCA.
DR   GeneTree; ENSGT00940000170295; -.
DR   InParanoid; P10041; -.
DR   KO; K06051; -.
DR   OMA; DKPCHQG; -.
DR   OrthoDB; 406049at2759; -.
DR   PhylomeDB; P10041; -.
DR   Reactome; R-DME-2979096; NOTCH2 Activation and Transmission of Signal to the Nucleus.
DR   Reactome; R-DME-9013507; NOTCH3 Activation and Transmission of Signal to the Nucleus.
DR   SignaLink; P10041; -.
DR   ChiTaRS; Dl; fly.
DR   GenomeRNAi; 42313; -.
DR   PMAP-CutDB; P10041; -.
DR   PRO; PR:P10041; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0000463; Expressed in 95 organ(s), highest expression level in embryo.
DR   ExpressionAtlas; P10041; baseline and differential.
DR   Genevisible; P10041; DM.
DR   GO; GO:0005912; C:adherens junction; IDA:FlyBase.
DR   GO; GO:0009986; C:cell surface; IDA:FlyBase.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IDA:FlyBase.
DR   GO; GO:0030139; C:endocytic vesicle; IDA:FlyBase.
DR   GO; GO:0005768; C:endosome; IDA:FlyBase.
DR   GO; GO:0016021; C:integral component of membrane; IDA:FlyBase.
DR   GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR   GO; GO:0035003; C:subapical complex; IDA:FlyBase.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005112; F:Notch binding; IDA:FlyBase.
DR   GO; GO:0048018; F:receptor ligand activity; IDA:FlyBase.
DR   GO; GO:0007015; P:actin filament organization; IMP:FlyBase.
DR   GO; GO:0048800; P:antennal morphogenesis; IMP:FlyBase.
DR   GO; GO:0007475; P:apposition of dorsal and ventral imaginal disc-derived wing surfaces; IMP:FlyBase.
DR   GO; GO:0008356; P:asymmetric cell division; TAS:FlyBase.
DR   GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase.
DR   GO; GO:0001708; P:cell fate specification; TAS:FlyBase.
DR   GO; GO:0008407; P:chaeta morphogenesis; IMP:FlyBase.
DR   GO; GO:0042676; P:compound eye cone cell fate commitment; TAS:FlyBase.
DR   GO; GO:0048749; P:compound eye development; TAS:FlyBase.
DR   GO; GO:0046667; P:compound eye retinal cell programmed cell death; TAS:FlyBase.
DR   GO; GO:0007451; P:dorsal/ventral lineage restriction, imaginal disc; TAS:FlyBase.
DR   GO; GO:0007398; P:ectoderm development; TAS:FlyBase.
DR   GO; GO:0042067; P:establishment of ommatidial planar polarity; TAS:FlyBase.
DR   GO; GO:0001736; P:establishment of planar polarity; NAS:FlyBase.
DR   GO; GO:0030718; P:germ-line stem cell population maintenance; IMP:FlyBase.
DR   GO; GO:0008347; P:glial cell migration; IMP:FlyBase.
DR   GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
DR   GO; GO:0036011; P:imaginal disc-derived leg segmentation; IMP:FlyBase.
DR   GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IMP:FlyBase.
DR   GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR   GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; TAS:FlyBase.
DR   GO; GO:0007474; P:imaginal disc-derived wing vein specification; NAS:FlyBase.
DR   GO; GO:0046331; P:lateral inhibition; IMP:FlyBase.
DR   GO; GO:0007498; P:mesoderm development; IMP:FlyBase.
DR   GO; GO:0050768; P:negative regulation of neurogenesis; IMP:FlyBase.
DR   GO; GO:0007399; P:nervous system development; NAS:FlyBase.
DR   GO; GO:0007219; P:Notch signaling pathway; IDA:FlyBase.
DR   GO; GO:0030720; P:oocyte localization involved in germarium-derived egg chamber formation; IMP:FlyBase.
DR   GO; GO:0048477; P:oogenesis; IMP:FlyBase.
DR   GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase.
DR   GO; GO:0030713; P:ovarian follicle cell stalk formation; IMP:FlyBase.
DR   GO; GO:0007422; P:peripheral nervous system development; IMP:FlyBase.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:FlyBase.
DR   GO; GO:0045931; P:positive regulation of mitotic cell cycle; IMP:FlyBase.
DR   GO; GO:0007464; P:R3/R4 cell fate commitment; NAS:FlyBase.
DR   GO; GO:0007460; P:R8 cell fate commitment; TAS:FlyBase.
DR   GO; GO:0016330; P:second mitotic wave involved in compound eye morphogenesis; IMP:FlyBase.
DR   GO; GO:0007423; P:sensory organ development; IMP:FlyBase.
DR   GO; GO:0048863; P:stem cell differentiation; IMP:FlyBase.
DR   GO; GO:0007419; P:ventral cord development; NAS:FlyBase.
DR   GO; GO:0048190; P:wing disc dorsal/ventral pattern formation; IMP:FlyBase.
DR   InterPro; IPR001774; DSL.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR011651; Notch_ligand_N.
DR   Pfam; PF01414; DSL; 1.
DR   Pfam; PF00008; EGF; 6.
DR   Pfam; PF12661; hEGF; 1.
DR   Pfam; PF07657; MNNL; 1.
DR   SMART; SM00051; DSL; 1.
DR   SMART; SM00181; EGF; 9.
DR   SMART; SM00179; EGF_CA; 7.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS51051; DSL; 1.
DR   PROSITE; PS00022; EGF_1; 9.
DR   PROSITE; PS01186; EGF_2; 9.
DR   PROSITE; PS50026; EGF_3; 7.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Developmental protein;
KW   Differentiation; Disulfide bond; EGF-like domain; Glycoprotein;
KW   Membrane; Neurogenesis; Notch signaling pathway; Phosphoprotein;
KW   Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix; Ubl conjugation.
FT   SIGNAL        1     18       {ECO:0000255}.
FT   CHAIN        19    833       Neurogenic locus protein delta.
FT                                /FTId=PRO_0000007505.
FT   TOPO_DOM     19    594       Extracellular. {ECO:0000255}.
FT   TRANSMEM    595    617       Helical. {ECO:0000255}.
FT   TOPO_DOM    618    833       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      182    226       DSL. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00377}.
FT   DOMAIN      227    258       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      256    289       EGF-like 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      291    329       EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      331    372       EGF-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      374    416       EGF-like 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      418    451       EGF-like 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      453    489       EGF-like 7; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      491    527       EGF-like 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      529    565       EGF-like 9; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   MOD_RES     666    666       Phosphothreonine.
FT                                {ECO:0000269|PubMed:18327897}.
FT   CARBOHYD     98     98       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    137    137       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    167    167       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     46     61       {ECO:0000250|UniProtKB:D3ZHH1}.
FT   DISULFID     68     82       {ECO:0000250|UniProtKB:D3ZHH1}.
FT   DISULFID    184    193       {ECO:0000250|UniProtKB:D3ZHH1,
FT                                ECO:0000255|PROSITE-ProRule:PRU00377}.
FT   DISULFID    197    209       {ECO:0000250|UniProtKB:D3ZHH1,
FT                                ECO:0000255|PROSITE-ProRule:PRU00377}.
FT   DISULFID    217    226       {ECO:0000250|UniProtKB:D3ZHH1,
FT                                ECO:0000255|PROSITE-ProRule:PRU00377}.
FT   DISULFID    231    240       {ECO:0000250|UniProtKB:D3ZHH1,
FT                                ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    235    246       {ECO:0000250|UniProtKB:D3ZHH1,
FT                                ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    248    257       {ECO:0000250|UniProtKB:D3ZHH1,
FT                                ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    260    271       {ECO:0000250|UniProtKB:D3ZHH1}.
FT   DISULFID    266    277       {ECO:0000250|UniProtKB:D3ZHH1}.
FT   DISULFID    279    288       {ECO:0000250|UniProtKB:D3ZHH1,
FT                                ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    295    307       {ECO:0000250}.
FT   DISULFID    301    317       {ECO:0000250}.
FT   DISULFID    319    328       {ECO:0000250}.
FT   DISULFID    335    348       {ECO:0000250}.
FT   DISULFID    342    360       {ECO:0000250}.
FT   DISULFID    362    371       {ECO:0000250}.
FT   DISULFID    378    388       {ECO:0000250}.
FT   DISULFID    383    404       {ECO:0000250}.
FT   DISULFID    406    415       {ECO:0000250}.
FT   DISULFID    422    433       {ECO:0000250}.
FT   DISULFID    427    439       {ECO:0000250}.
FT   DISULFID    441    450       {ECO:0000250}.
FT   DISULFID    457    468       {ECO:0000250}.
FT   DISULFID    462    477       {ECO:0000250}.
FT   DISULFID    479    488       {ECO:0000250}.
FT   DISULFID    495    506       {ECO:0000250}.
FT   DISULFID    500    515       {ECO:0000250}.
FT   DISULFID    517    526       {ECO:0000250}.
FT   DISULFID    533    544       {ECO:0000250}.
FT   DISULFID    538    553       {ECO:0000250}.
FT   DISULFID    555    564       {ECO:0000250}.
FT   VARIANT     398    398       K -> R (in strain: sonoma_017).
FT   VARIANT     443    443       A -> T (in strain: sonoma_009,
FT                                sonoma_051, sonoma_053 and sonoma_054).
FT   VARIANT     461    461       Q -> K (in strain: sonoma_010,
FT                                sonoma_013, sonoma_019 and sonoma_117).
FT   VARIANT     652    652       G -> A (in strain: NapaValley5,
FT                                NapaValley12, sonoma_015, sonoma_016,
FT                                sonoma_023, sonoma_032, sonoma_034,
FT                                sonoma_038, sonoma_040, sonoma_045,
FT                                sonoma_048, sonoma_050, sonoma_061,
FT                                sonoma_073, sonoma_081, sonoma_085,
FT                                sonoma_094, sonoma_097 and sonoma_119).
FT                                {ECO:0000269|PubMed:16453806}.
FT   VARIANT     662    662       L -> M (in strain: sonoma_008,
FT                                sonoma_015, sonoma_016, sonoma_032,
FT                                sonoma_034, sonoma_038, sonoma_040,
FT                                sonoma_045, sonoma_048, sonoma_050,
FT                                sonoma_061, sonoma_073, sonoma_081,
FT                                sonoma_085, sonoma_094 and sonoma_097).
FT                                {ECO:0000269|PubMed:16453806}.
FT   VARIANT     761    761       A -> T (in strain: sonoma_006, sonoma_022
FT                                and sonoma_040).
FT   VARIANT     787    787       S -> G (in strain: nps_6, nps_18, nps_34,
FT                                sonoma_048 and sonoma_050).
FT   VARIANT     800    800       G -> R (in strain: sonoma_002).
FT   VARIANT     812    812       V -> A (in strain: nps_19, nps_21,
FT                                nps_25, nps_26, nps_27, nps_30, nps_31,
FT                                nps_33, nps_35, nps_42, nps_43, nps_45,
FT                                nps_47, sonoma_002, sonoma_003,
FT                                sonoma_004, sonoma_005, sonoma_006,
FT                                sonoma_007, sonoma_008, sonoma_009,
FT                                sonoma_014, sonoma_016, sonoma_017,
FT                                sonoma_022, sonoma_024, sonoma_032,
FT                                sonoma_033, sonoma_036, sonoma_038,
FT                                sonoma_045, sonoma_051, sonoma_053,
FT                                sonoma_054, sonoma_055, sonoma_059,
FT                                sonoma_061, sonoma_064, sonoma_081,
FT                                sonoma_086, sonoma_087, sonoma_094,
FT                                sonoma_095, sonoma_097, sonoma_106,
FT                                sonoma_107 and sonoma_119).
FT                                {ECO:0000269|PubMed:3149249}.
FT   CONFLICT    437    438       GK -> ET (in Ref. 8; CAA28786).
FT                                {ECO:0000305}.
FT   CONFLICT    443    443       A -> S (in Ref. 8; CAA28786).
FT                                {ECO:0000305}.
FT   CONFLICT    459    459       G -> A (in Ref. 8; CAA28786).
FT                                {ECO:0000305}.
FT   CONFLICT    490    490       S -> T (in Ref. 8; CAA28786).
FT                                {ECO:0000305}.
FT   CONFLICT    591    591       T -> A (in Ref. 8; CAA28786).
FT                                {ECO:0000305}.
SQ   SEQUENCE   833 AA;  88841 MW;  EDBA107A0003D9A1 CRC64;
     MHWIKCLLTA FICFTVIVQV HSSGSFELRL KYFSNDHGRD NEGRCCSGES DGATGKCLGS
     CKTRFRVCLK HYQATIDTTS QCTYGDVITP ILGENSVNLT DAQRFQNKGF TNPIQFPFSF
     SWPGTFSLIV EAWHDTNNSG NARTNKLLIQ RLLVQQVLEV SSEWKTNKSE SQYTSLEYDF
     RVTCDLNYYG SGCAKFCRPR DDSFGHSTCS ETGEIICLTG WQGDYCHIPK CAKGCEHGHC
     DKPNQCVCQL GWKGALCNEC VLEPNCIHGT CNKPWTCICN EGWGGLYCNQ DLNYCTNHRP
     CKNGGTCFNT GEGLYTCKCA PGYSGDDCEN EIYSCDADVN PCQNGGTCID EPHTKTGYKC
     HCANGWSGKM CEEKVLTCSD KPCHQGICRN VRPGLGSKGQ GYQCECPIGY SGPNCDLQLD
     NCSPNPCING GSCQPSGKCI CPAGFSGTRC ETNIDDCLGH QCENGGTCID MVNQYRCQCV
     PGFHGTHCSS KVDLCLIRPC ANGGTCLNLN NDYQCTCRAG FTGKDCSVDI DECSSGPCHN
     GGTCMNRVNS FECVCANGFR GKQCDEESYD SVTFDAHQYG ATTQARADGL TNAQVVLIAV
     FSVAMPLVAV IAACVVFCMK RKRKRAQEKD DAEARKQNEQ NAVATMHHNG SGVGVALASA
     SLGGKTGSNS GLTFDGGNPN IIKNTWDKSV NNICASAAAA AAAAAAADEC LMYGGYVASV
     ADNNNANSDF CVAPLQRAKS QKQLNTDPTL MHRGSPAGSS AKGASGGGPG AAEGKRISVL
     GEGSYCSQRW PSLAAAGVAG ACSSQLMAAA SVAGSGAGTA QQQRSVVCGT PHM
//
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