ID ZFY1_MOUSE Reviewed; 782 AA.
AC P10925; E9QKM5; Q8C638;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 27-MAR-2024, entry version 176.
DE RecName: Full=Zinc finger Y-chromosomal protein 1;
GN Name=Zfy1; Synonyms=Zfy-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=2497440; DOI=10.1093/nar/17.7.2864;
RA Ashworth A., Swift S., Affara N.;
RT "Sequence of cDNA for murine Zfy-1, a candidate for Tdy.";
RL Nucleic Acids Res. 17:2864-2864(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Probable transcriptional activator. Binds to the consensus
CC sequence 5'-AGGCCY-3' (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DOMAIN: The binding of ZFY to DNA is mediated by the interaction of the
CC GGCC core base pairs with zinc fingers 12 and 13. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. ZFX/ZFY subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X14382; CAA32552.1; -; mRNA.
DR EMBL; AK076618; BAC36419.1; -; mRNA.
DR EMBL; AC139318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS30539.1; -.
DR PIR; S04047; S04047.
DR RefSeq; NP_033596.3; NM_009570.4.
DR AlphaFoldDB; P10925; -.
DR SMR; P10925; -.
DR STRING; 10090.ENSMUSP00000140600; -.
DR iPTMnet; P10925; -.
DR PhosphoSitePlus; P10925; -.
DR MaxQB; P10925; -.
DR PaxDb; 10090-ENSMUSP00000069364; -.
DR ProteomicsDB; 302057; -.
DR DNASU; 22767; -.
DR Ensembl; ENSMUST00000065545.6; ENSMUSP00000069364.5; ENSMUSG00000053211.11.
DR Ensembl; ENSMUST00000189888.7; ENSMUSP00000140600.2; ENSMUSG00000053211.11.
DR GeneID; 22767; -.
DR KEGG; mmu:22767; -.
DR UCSC; uc009uyv.2; mouse.
DR AGR; MGI:99212; -.
DR CTD; 22767; -.
DR MGI; MGI:99212; Zfy1.
DR VEuPathDB; HostDB:ENSMUSG00000053211; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164731; -.
DR HOGENOM; CLU_021097_0_0_1; -.
DR InParanoid; P10925; -.
DR OrthoDB; 4793691at2759; -.
DR PhylomeDB; P10925; -.
DR TreeFam; TF335557; -.
DR BioGRID-ORCS; 22767; 2 hits in 77 CRISPR screens.
DR ChiTaRS; Zfy1; mouse.
DR PRO; PR:P10925; -.
DR Proteomes; UP000000589; Chromosome Y.
DR RNAct; P10925; Protein.
DR Bgee; ENSMUSG00000053211; Expressed in ureteric bud trunk and 25 other cell types or tissues.
DR Genevisible; P10925; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR InterPro; IPR006794; Transcrp_activ_Zfx/Zfy-dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24404; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24404:SF89; ZINC FINGER PROTEIN GFI-1; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR Pfam; PF04704; Zfx_Zfy_act; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..782
FT /note="Zinc finger Y-chromosomal protein 1"
FT /id="PRO_0000047263"
FT ZN_FING 403..425
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 434..456
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 466..488
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 497..520
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 526..548
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 554..577
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 583..605
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 611..634
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 640..662
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 668..691
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 697..719
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 725..748
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 754..777
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 211..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 372..382
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 215..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 8
FT /note="L -> S (in Ref. 1; CAA32552)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="A -> T (in Ref. 1; CAA32552)"
FT /evidence="ECO:0000305"
FT CONFLICT 226
FT /note="G -> E (in Ref. 1; CAA32552)"
FT /evidence="ECO:0000305"
FT CONFLICT 253..254
FT /note="EL -> DV (in Ref. 1; CAA32552)"
FT /evidence="ECO:0000305"
FT CONFLICT 388
FT /note="Q -> K (in Ref. 1; CAA32552)"
FT /evidence="ECO:0000305"
FT CONFLICT 595
FT /note="N -> T (in Ref. 1; CAA32552)"
FT /evidence="ECO:0000305"
FT CONFLICT 679
FT /note="D -> N (in Ref. 2; BAC36419)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 782 AA; 88230 MW; 27473EF40C051236 CRC64;
MDEDEIELTP EEEKSFFDGI GADAVHMDSD QIVVEVQETV FLANSDVTVH NFVPDNPGSV
IIQDVIENVL IEDVHCSHIL EETDISDNVI IPEQVLNLGT AEEVSLAQFL IPDILTSGIT
STSLTMPEHV LMSEAIHVSD VGHFEQVIHD SLVETEVITD PITADTSDIL VADCVSEAVL
DSSGMPLEQQ DNDKINCEDY LMMSLDEPSK ADLEGSSEVT MNAESGTDSS KLDEASPEVI
KVCILKADSE VDELGETIHA VESETKNGNE AEVTDQSTSI RVPRVNIYMS ASDSQKEEED
TEVIVGDEDA GGTAADTPEH EQQMDVSEIK AAFLPIAWTA AYDNNSDEIE DQNVTASALL
NQDESGGLDR VPKQKSKKKK RPESKQYQSA IFVAPDGQTL RVYPCMFCGK KFKTKRFLKR
HTKNHPEYLA NKKYHCTECD YSTNKKISLH NHMESHKLTI KTEKTTECDD CRKNLSHAGT
LCTHKTMHTE KGVNKTCKCK FCDYETAEQT LLNHHLLVVH RKKFPHICGE CGKGFRHPSA
LKKHIRVHTG EKPYECQYCE YKSADSSNLK THIKSKHSKE IPLKCGICLL TFSDNKEAQQ
HAVLHQESRT HQCSHCNHKS SNSSDLKRHI ISVHTKAYPH KCDMCSKGFH RPSELKKHVA
THKSKKMHQC RHCDFNSPDP FLLSHHILSA HTKNVPFKCK RCKKEFQQQC ELQTHMKTHS
SRKVYQCEYC EYSTKDASGF KRHVISIHTK DYPHSCDFCK KGFRRPSEKN QHIMRHHKVG
LP
//
