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Database: UniProt
Entry: P13187
LinkDB: P13187
Original site: P13187 
ID   DCOA_KLEPN              Reviewed;         596 AA.
AC   P13187;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   13-FEB-2019, entry version 96.
DE   RecName: Full=Oxaloacetate decarboxylase alpha chain;
DE            EC=7.2.4.2;
GN   Name=oadA;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2454915;
RA   Schwarz E., Oesterhelt D., Reinke H., Beyreuther K., Dimroth P.;
RT   "The sodium ion translocating oxalacetate decarboxylase of Klebsiella
RT   pneumoniae. Sequence of the biotin-containing alpha-subunit and
RT   relationship to other biotin-containing enzymes.";
RL   J. Biol. Chem. 263:9640-9645(1988).
CC   -!- FUNCTION: Catalyzes the decarboxylation of oxaloacetate coupled to
CC       Na(+) translocation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) +
CC         pyruvate; Xref=Rhea:RHEA:57724, ChEBI:CHEBI:15361,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:29101; EC=7.2.4.2;
CC   -!- COFACTOR:
CC       Name=biotin; Xref=ChEBI:CHEBI:57586;
CC   -!- SUBUNIT: Composed of three chains (alpha, beta, and gamma).
CC       {ECO:0000250}.
DR   EMBL; J03885; AAA25120.1; -; Genomic_DNA.
DR   PIR; A28088; A28088.
DR   RefSeq; WP_004222624.1; NZ_ULDO01000002.1.
DR   ProteinModelPortal; P13187; -.
DR   SMR; P13187; -.
DR   eggNOG; ENOG4107QSA; Bacteria.
DR   eggNOG; COG0511; LUCA.
DR   eggNOG; COG5016; LUCA.
DR   BioCyc; KPNE1049565:G1GZ9-540-MONOMER; -.
DR   GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001882; Biotin_BS.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR003379; Carboxylase_cons_dom.
DR   InterPro; IPR005776; OadA.
DR   InterPro; IPR000891; PYR_CT.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   Pfam; PF02436; PYC_OADA; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   TIGRFAMs; TIGR01108; oadA; 1.
DR   PROSITE; PS00188; BIOTIN; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Biotin; Ion transport; Sodium; Sodium transport; Translocase;
KW   Transport.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    596       Oxaloacetate decarboxylase alpha chain.
FT                                /FTId=PRO_0000146833.
FT   DOMAIN        3    263       Pyruvate carboxyltransferase.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01151}.
FT   DOMAIN      523    596       Biotinyl-binding. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01066}.
FT   MOD_RES     562    562       N6-biotinyllysine. {ECO:0000250,
FT                                ECO:0000255|PROSITE-ProRule:PRU01066}.
SQ   SEQUENCE   596 AA;  63534 MW;  284928FC45397054 CRC64;
     MTVAITDVVL RDAHQSLFAT RLRLDDMLPV AAQLDDVGYR SLECWGGATF DACIRFLGED
     PWVRLRELKK AMPKTPLQML LRGQNLLGYR HYADDVVERF VERAVKNGMD VFRVFDAMND
     PRNMQAALQA VRRHGAHAQG TLSYTTSPAH TLQTWLDLTE QLLETGVDSV AIKDMSGILT
     PHAAFELVSE IKKRYDVTLH LHCHATTGMA EMALLKAIEA GVDGVDTAIS SMSATYGHPA
     TEALVATLAG TPYDTGLDIH KLESIAAYFR EVRKKYHAFE GQLKGTDSRI LVAQVPGGML
     TNLEGQLKQQ SAAHRLDEVL AEIPRVREDL GFIPLVTPTS QIVGTQAVLN VLTGERYKTI
     AKETAGILKG EYGRTPAPVN AALQARVLDG ADPVTCRPAD LLKPELAQLE ADVRRQAQEK
     GITLAENAID DVLTVALFPQ PGLKFLENRH NPAAFEPVPQ AEAAQPVAKA EKPAASGVYT
     VEVEGKAFVV KVSDGGDVSQ LTAAAPAPAP APAPASAPAA AAPAGAGTPV TAPLAGTIWK
     VLASEGQTVA AGEVLLILEA MKMETEIRAA QAGTVRGIAV KAGDAVAVGD TLMTLA
//
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