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Database: UniProt
Entry: P13474
LinkDB: P13474
Original site: P13474 
ID   ETS1A_CHICK             Reviewed;         441 AA.
AC   P13474;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   07-OCT-2020, entry version 150.
DE   RecName: Full=Transforming protein p54/c-ets-1;
GN   Name=ETS1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spleen;
RX   PubMed=3041344;
RA   Duterque-Coquillaud M., Leprince D., Flourens A., Henry C., Ghysdael J.,
RA   Debuire B., Stehelin D.;
RT   "Cloning and expression of chicken p54c-ets cDNAs: the first p54c-ets
RT   coding exon is located into the 40.0 kbp genomic domain unrelated to v-
RT   ets.";
RL   Oncogene Res. 2:335-344(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spleen;
RX   PubMed=3041346;
RA   Chen J.H.;
RT   "Complementary DNA clones of chicken proto-oncogene c-ets: sequence
RT   divergence from the viral oncogene v-ets.";
RL   Oncogene Res. 2:371-384(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2847407; DOI=10.1016/0042-6822(88)90047-5;
RA   Watson D.K., McWilliams M.J., Papas T.S.;
RT   "A unique amino-terminal sequence predicted for the chicken proto-ets
RT   protein.";
RL   Virology 167:1-7(1988).
RN   [4]
RP   ALTERNATIVE PROMOTER USAGE.
RX   PubMed=8268721;
RA   Crepieux P., Leprince D., Flourens A., Albagli O., Ferreira E.,
RA   Stehelin D.;
RT   "The two functionally distinct amino termini of chicken c-ets-1 products
RT   arise from alternative promoter usage.";
RL   Gene Expr. 3:215-225(1993).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- SUBUNIT: Binds DNA as a homodimer; homodimerization is required for
CC       transcription activation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P14921}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative promoter usage; Named isoforms=2;
CC       Name=p54;
CC         IsoId=P13474-1; Sequence=Displayed;
CC       Name=p68;
CC         IsoId=P15062-1; Sequence=External;
CC   -!- TISSUE SPECIFICITY: Thymus.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
DR   EMBL; M22462; AAA48764.1; -; mRNA.
DR   EMBL; X13026; CAA31441.1; -; mRNA.
DR   EMBL; X13027; CAA31442.1; -; mRNA.
DR   PIR; A31285; TVCHTE.
DR   RefSeq; NP_990629.2; NM_205298.2. [P13474-1]
DR   SMR; P13474; -.
DR   iPTMnet; P13474; -.
DR   GeneID; 396235; -.
DR   KEGG; gga:396235; -.
DR   CTD; 2113; -.
DR   KO; K02678; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0042025; C:host cell nucleus; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR   GO; GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB.
DR   CDD; cd08542; SAM_PNT-ETS-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041886; SAM_PNT-ETS-1.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   Alternative promoter usage; DNA-binding; Nucleus; Phosphoprotein;
KW   Proto-oncogene; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..441
FT                   /note="Transforming protein p54/c-ets-1"
FT                   /id="PRO_0000204072"
FT   DOMAIN          51..136
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        335..415
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          130..243
FT                   /note="Activation domain; required for transcription
FT                   activation"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         38
FT                   /note="Phosphothreonine; by MAPK"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        117
FT                   /note="R -> A (in Ref. 3; AAA48764)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   441 AA;  50327 MW;  5CF3C575CCE115F5 CRC64;
     MKAAVDLKPT LTIIKTEKVD IDLFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFAKEQ
     QRLGIPKDPQ QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK ECFLELRPDF
     VGDILWEHLE ILQKEEAKPY PANGVNAAYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF
     ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPVQTDSLQ TDYFTIKQEV VTPDNMCMGR
     ASRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFQSLQRV PSYDSFDSED YPAALPNHKP
     KGTFKDYVRD RADMNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG
     WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN IIHKTAGKRY VYRFVCDLQS
     LLGYTPEELH AMLDVKPDAD E
//
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