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Database: UniProt
Entry: P14197
LinkDB: P14197
Original site: P14197 
ID   AAC3_DICDI              Reviewed;         478 AA.
AC   P14197; Q552A2; Q75JM2;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   24-JAN-2024, entry version 131.
DE   RecName: Full=WD repeat-containing protein AAC3;
DE   AltName: Full=AAC-rich mRNA clone AAC3 protein;
GN   Name=AAC3; ORFNames=DDB_G0276031;
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 42-478, AND DEVELOPMENTAL STAGE.
RX   PubMed=2511421; DOI=10.1007/bf00332409;
RA   Shaw D.R., Richter H., Giorda R., Ohmachi T., Ennis H.L.;
RT   "Nucleotide sequences of Dictyostelium discoideum developmentally regulated
RT   cDNAs rich in (AAC) imply proteins that contain clusters of asparagine,
RT   glutamine, or threonine.";
RL   Mol. Gen. Genet. 218:453-459(1989).
CC   -!- DEVELOPMENTAL STAGE: The concentration of AAC-rich mRNAs is low in
CC       dormant spores and growing cells, but increases during spore-
CC       germination and multicellular development.
CC       {ECO:0000269|PubMed:2511421}.
CC   -!- MISCELLANEOUS: Several proteins derive from AAC-rich mRNA, which, due
CC       to a frameshift also have ACA and CAA codons and thus are Asn-, Thr- or
CC       Gln-rich.
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DR   EMBL; AAFI02000014; EAL69315.1; -; Genomic_DNA.
DR   EMBL; X16524; CAA34531.1; -; mRNA.
DR   PIR; S05357; S05357.
DR   RefSeq; XP_643326.1; XM_638234.1.
DR   AlphaFoldDB; P14197; -.
DR   SMR; P14197; -.
DR   STRING; 44689.P14197; -.
DR   PaxDb; 44689-DDB0185151; -.
DR   EnsemblProtists; EAL69315; EAL69315; DDB_G0276031.
DR   GeneID; 8620373; -.
DR   KEGG; ddi:DDB_G0276031; -.
DR   dictyBase; DDB_G0276031; -.
DR   eggNOG; KOG1407; Eukaryota.
DR   HOGENOM; CLU_045202_0_0_1; -.
DR   InParanoid; P14197; -.
DR   OMA; YQHEINE; -.
DR   PhylomeDB; P14197; -.
DR   PRO; PR:P14197; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0000445; C:THO complex part of transcription export complex; IBA:GO_Central.
DR   GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR040132; Tex1/THOC3.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR22839:SF0; THO COMPLEX SUBUNIT 3; 1.
DR   PANTHER; PTHR22839; THO COMPLEX SUBUNIT 3 THO3; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..478
FT                   /note="WD repeat-containing protein AAC3"
FT                   /id="PRO_0000050830"
FT   REPEAT          163..202
FT                   /note="WD 1"
FT   REPEAT          226..268
FT                   /note="WD 2"
FT   REPEAT          270..307
FT                   /note="WD 3"
FT   REPEAT          310..349
FT                   /note="WD 4"
FT   REPEAT          357..396
FT                   /note="WD 5"
FT   REPEAT          399..438
FT                   /note="WD 6"
FT   REPEAT          440..478
FT                   /note="WD 7"
FT   REGION          33..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   478 AA;  53771 MW;  6B67D7BFDDED38EA CRC64;
     MGSRLNPSSN MYIPMNGPRG GYYGMPSMGQ LQHPLFNYQF PPGGFQHLQQ QQQQQQQQQQ
     QQQQQQQQQT QVQQLHNQLH QQHNQQIQQQ AQATQQHLQT QQYLQSQIHQ QSQQSQLSNN
     LNSNSKESTN IPKTNTQYTN FDSKNLDLAS RYFSECSTKD FIGNKKKSTS VAWNANGTKI
     ASSGSDGIVR VWNFDPLGNS NNNNNSNNTS SNSKNNNIKE TIELKGHDGS IEKISWSPKN
     NDLLASAGTD KVIKIWDVKI GKCIGTVSTN SENIDVRWSP DGQFIVACTR DDHLALIDLP
     TIKTLKIYKF NGEELNQVGW DNNGDLILMA NSMGNIEAYK FLPKSTTHVK HLKTLYGHTA
     SIYCMEFDPT GKYLAAGSAD SIVSLWDIED MMCVKTFIKS TFPCRSVSFS FDGQFIAASS
     FESTIEIFHI ESSQPIHTIE CSGVSSLMWH PTLPLLAYAP EINENNKDPS IRVFGYHS
//
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