GenomeNet

Database: UniProt
Entry: P15062
LinkDB: P15062
Original site: P15062 
ID   ETS1B_CHICK             Reviewed;         485 AA.
AC   P15062;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   12-AUG-2020, entry version 128.
DE   RecName: Full=Transforming protein p68/c-ets-1;
GN   Name=ETS1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2841475;
RA   Leprince D., Duterque-Coquillaud M., Li R.-P., Henry C., Flourens A.,
RA   Debuire B., Stehelin D.;
RT   "Alternative splicing within the chicken c-ets-1 locus: implications for
RT   transduction within the E26 retrovirus of the c-ets proto-oncogene.";
RL   J. Virol. 62:3233-3241(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3284179; DOI=10.1016/0042-6822(88)90624-1;
RA   Watson D.K., McWilliams M.J., Papas T.S.;
RT   "Molecular organization of the chicken ets locus.";
RL   Virology 164:99-105(1988).
RN   [3]
RP   ALTERNATIVE PROMOTER USAGE.
RX   PubMed=8268721;
RA   Crepieux P., Leprince D., Flourens A., Albagli O., Ferreira E.,
RA   Stehelin D.;
RT   "The two functionally distinct amino termini of chicken c-ets-1 products
RT   arise from alternative promoter usage.";
RL   Gene Expr. 3:215-225(1993).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- SUBUNIT: Binds DNA as a homodimer; homodimerization is required for
CC       transcription activation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P14921}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative promoter usage; Named isoforms=2;
CC       Name=p68;
CC         IsoId=P15062-1; Sequence=Displayed;
CC       Name=p54;
CC         IsoId=P13474-1; Sequence=External;
CC   -!- TISSUE SPECIFICITY: Spleen.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA48668.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
DR   EMBL; M21823; AAA48669.1; -; mRNA.
DR   EMBL; AH002441; AAA48668.1; ALT_INIT; Genomic_DNA.
DR   PIR; A28875; TVCHET.
DR   SMR; P15062; -.
DR   STRING; 9031.ENSGALP00000001717; -.
DR   PaxDb; P15062; -.
DR   eggNOG; KOG3806; Eukaryota.
DR   InParanoid; P15062; -.
DR   PhylomeDB; P15062; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0042025; C:host cell nucleus; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR   GO; GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd08542; SAM_PNT-ETS-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041886; SAM_PNT-ETS-1.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   Alternative promoter usage; DNA-binding; Nucleus; Proto-oncogene;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..485
FT                   /note="Transforming protein p68/c-ets-1"
FT                   /id="PRO_0000204073"
FT   DOMAIN          95..180
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        379..459
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          174..287
FT                   /note="Activation domain; required for transcription
FT                   activation"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        220
FT                   /note="S -> C (in Ref. 2; AAA48668)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        222
FT                   /note="P -> R (in Ref. 2; AAA48668)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   485 AA;  55021 MW;  81576B43BEF62648 CRC64;
     MMSYYMDTTI GSTGPYPLAR PGVMQGASSC CEDPWMPCRL QSACCPPRSC CPPWDEAAIQ
     EVPTGLEHYS TDMECADVPL LTPSSKEMMS QALKATFSGF AKEQQRLGIP KDPQQWTETH
     VRDWVMWAVN EFSLKGVDFQ KFCMNGAALC ALGKECFLEL APDFVGDILW EHLEILQKEE
     AKPYPANGVN AAYPESRYTS DYFISYGIEH AQCVPPSEFS EPSFITESYQ TLHPISSEEL
     LSLKYENDYP SVILRDPVQT DSLQTDYFTI KQEVVTPDNM CMGRASRGKL GGQDSFESIE
     SYDSCDRLTQ SWSSQSSFQS LQRVPSYDSF DSEDYPAALP NHKPKGTFKD YVRDRADMNK
     DKPVIPAAAL AGYTGSGPIQ LWQFLLELLT DKSCQSFISW TGDGWEFKLS DPDEVARRWG
     KRKNKPKMNY EKLSRGLRYY YDKNIIHKTA GKRYVYRFVC DLQSLLGYTP EELHAMLDVK
     PDADE
//
DBGET integrated database retrieval system