ID HLAE_PONPY Reviewed; 359 AA.
AC P16212;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 28-JUN-2023, entry version 111.
DE RecName: Full=Popy class I histocompatibility antigen, alpha chain E;
DE AltName: Full=MHC class I antigen E;
DE Flags: Precursor; Fragment;
GN Name=Popy-E;
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1690682; DOI=10.1111/j.1600-065x.1990.tb00040.x;
RA Lawlor D.A., Warren E., Ward F.E., Parham P.;
RT "Comparison of class I MHC alleles in humans and apes.";
RL Immunol. Rev. 113:147-185(1990).
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC microglobulin).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}.
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DR EMBL; M30681; AAA88836.1; -; mRNA.
DR PIR; I61867; I61867.
DR AlphaFoldDB; P16212; -.
DR SMR; P16212; -.
DR GlyCosmos; P16212; 1 site, No reported glycans.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProt.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProt.
DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProt.
DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd07698; IgC1_MHC_I_alpha3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR InterPro; IPR010579; MHC_I_a_C.
DR PANTHER; PTHR16675:SF164; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN E; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR Pfam; PF06623; MHC_I_C; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; Phosphoprotein;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL <1..18
FT CHAIN 19..359
FT /note="Popy class I histocompatibility antigen, alpha chain
FT E"
FT /id="PRO_0000018919"
FT TOPO_DOM 19..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 203..291
FT /note="Ig-like C1-type"
FT REGION 19..108
FT /note="Alpha-1"
FT REGION 109..200
FT /note="Alpha-2"
FT REGION 201..292
FT /note="Alpha-3"
FT REGION 293..302
FT /note="Connecting peptide"
FT REGION 330..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 351
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P01900"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT DISULFID 119..182
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 221..277
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 1
SQ SEQUENCE 359 AA; 40409 MW; 4B2BE601B91D9966 CRC64;
GTLLLLLSEA LALTETWAGS HSLKYFHTSV SRPGRGEPRF ISVGYVDDTQ FVRFDNDAAS
PRMVPRAQWM EQEGPEYWDR ETRSARDTAQ TFRVNLRTLR GYYNQTEAGS HTLQWMHGCD
LGPDGRFLRG YEQFAYDGKD YLTLNEDLRS WTAVDTAAQI SERKSNDACE AEHQRAYLED
TCVEWLRKYL EKGKETLLHL DPPKTHVTHH RISDHEATLR CWALGFYPAE ITLTWQRDGE
DQNQYTELVE TRPAGDGTFQ KWAAVVVPSG EEQRYTCHVQ HEGLPEPLTL RWEPASQTTI
PIVGIFAGLV LLGAVVTGAT VVAAVMWRKK SSGGKGGSYS KAEWSDSAQG SESLTACKA
//
