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Database: UniProt
Entry: P16230
LinkDB: P16230
Original site: P16230 
ID   SRCH_RABIT              Reviewed;         852 AA.
AC   P16230;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   12-SEP-2018, entry version 91.
DE   RecName: Full=Sarcoplasmic reticulum histidine-rich calcium-binding protein;
DE   Flags: Precursor;
GN   Name=HRC; Synonyms=HCP;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND
RP   PYROGLUTAMATE FORMATION AT GLN-28.
RC   TISSUE=Skeletal muscle;
RX   PubMed=2808365;
RA   Hofmann S.L., Goldstein J.L., Orth K., Moomaw C.R., Slaughter C.A.,
RA   Brown M.S.;
RT   "Molecular cloning of a histidine-rich Ca2+-binding protein of
RT   sarcoplasmic reticulum that contains highly conserved repeated
RT   elements.";
RL   J. Biol. Chem. 264:18083-18090(1989).
CC   -!- FUNCTION: May play a role in the regulation of calcium
CC       sequestration or release in the SR of skeletal and cardiac muscle.
CC   -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen.
CC   -!- PTM: The N-terminus is blocked. {ECO:0000269|PubMed:2808365}.
CC   -!- SIMILARITY: Belongs to the HRC family. {ECO:0000305}.
DR   EMBL; J05080; AAA31279.1; -; mRNA.
DR   PIR; A34373; A34373.
DR   RefSeq; NP_001075703.1; NM_001082234.1.
DR   UniGene; Ocu.1888; -.
DR   MINT; P16230; -.
DR   GeneID; 100009049; -.
DR   KEGG; ocu:100009049; -.
DR   CTD; 3270; -.
DR   HOVERGEN; HBG016630; -.
DR   InParanoid; P16230; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0033018; C:sarcoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR002134; His-rich_Ca-bd_rpt.
DR   InterPro; IPR019552; Hist_rich_Ca-bd.
DR   InterPro; IPR015666; HRC.
DR   PANTHER; PTHR15054; PTHR15054; 2.
DR   Pfam; PF10529; Hist_rich_Ca-bd; 11.
DR   PROSITE; PS00328; HCP; 10.
PE   1: Evidence at protein level;
KW   Calcium; Complete proteome; Direct protein sequencing; Phosphoprotein;
KW   Pyrrolidone carboxylic acid; Reference proteome; Repeat;
KW   Sarcoplasmic reticulum; Signal.
FT   SIGNAL        1     27       {ECO:0000255}.
FT   CHAIN        28    852       Sarcoplasmic reticulum histidine-rich
FT                                calcium-binding protein.
FT                                /FTId=PRO_0000022415.
FT   REPEAT       59     79       1-1.
FT   REPEAT       80    100       1-2.
FT   REPEAT      199    224       2-1.
FT   REPEAT      225    253       2-2.
FT   REPEAT      254    282       2-3.
FT   REPEAT      283    310       2-4.
FT   REPEAT      311    339       2-5.
FT   REPEAT      340    367       2-6.
FT   REPEAT      368    395       2-7.
FT   REPEAT      396    423       2-8.
FT   REPEAT      424    451       2-9.
FT   REPEAT      452    470       2-10.
FT   REGION       59    100       2 X approximate tandem repeats.
FT   REGION      199    470       10 X tandem repeats, acidic.
FT   REGION      471    585       4 X approximate tandem repeats.
FT   REGION      780    826       Metal-binding. {ECO:0000255}.
FT   COMPBIAS    721    733       Poly-Glu.
FT   MOD_RES      28     28       Pyrrolidone carboxylic acid.
FT                                {ECO:0000305|PubMed:2808365}.
FT   MOD_RES     120    120       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P23327}.
FT   MOD_RES     518    518       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P23327}.
FT   MOD_RES     544    544       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P23327}.
FT   MOD_RES     614    614       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P23327}.
SQ   SEQUENCE   852 AA;  96117 MW;  A43C0CB3E494B930 CRC64;
     MGCRGPWLHT CLLWAAVASL LLPPAVTQQL RGAGLGPSTW INNAGAPGPS GEAAAAGLGH
     HGHSHRSPGE ENEDVSMENG HHFWSHRDHG ETDDEVSREY GHQPQGHRYH SPEAGDESVS
     EEGVHREQAR QAPGHGGHGE AGAEDLAEHG SHGHGHEEED EDVISSERPR HVLRRAPRGH
     GGEEEGEEEE EEEEVSPEHR HRGHGKEDEE DEDDDSTESD RHQAHRHRGH REEEDEDDDD
     DEGDSTESDH HQAHRHRGHE EEEDEEDDDD EGDSTESDRH QAHRHRGHRE EEDEDDDDEG
     DSTESDRHQA HRHRGHREEE DDDDDDDEGD STESDRHQAH RHRGHREEED EDDDDEGDST
     ESDRHQAHRH RGHREEEDED DDDEGDSTES DRHQAHRHRG HREEEDEDDD DEGDSTESDH
     HQAHRHRGHR EEEDEEDDDE GDSTESDRHQ AHRHRGHGEE EDEDDDDEGE HHHVPHRGHR
     GHEEDDGGDD DDGDDSTENG HQAHRHQGHG KEEAEVTSDE HHHHVPDHGH QGHGDKEGEE
     EGVSTDHWHQ VPRHAHHGPG GEEEGGEEEL TVKAGHHVAS HPPPGHRSRE GHAEEHQTEV
     PGHHQHRMGD TDTSAERGHP ASSPRQQGHP PEDTVHHHRG SLKEEVGPES PGPAGVKDGS
     RVKRGGSEEE EEQKGTHHHS LEDEEDEEEG HGRSLSQEDQ EEEDRRGESA KVQAPLRHHR
     EEEEEEEEEE EEEGRLPFTI IPNPLSGREA AGGASSEESA EDTGPEDTQE YGNYQQGSLC
     GYCTFCNRCT ECEHCHCDED SMGEHCDQCQ HCQFCYLCPL VCETVCTPGS YVDYFSSSLY
     KALADMLETP EP
//
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