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Database: UniProt
Entry: P16600
LinkDB: P16600
Original site: P16600 
ID   KITH_SHEVK              Reviewed;         177 AA.
AC   P16600;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   05-DEC-2018, entry version 61.
DE   RecName: Full=Thymidine kinase;
DE            EC=2.7.1.21;
GN   Name=TK;
OS   Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1)).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Capripoxvirus.
OX   NCBI_TaxID=10269;
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2732700; DOI=10.1099/0022-1317-70-3-525;
RA   Gershon P.D., Black D.N.;
RT   "The nucleotide sequence around the capripoxvirus thymidine kinase
RT   gene reveals a gene shared specifically with leporipoxvirus.";
RL   J. Gen. Virol. 70:525-533(1989).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+);
CC         Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216;
CC         EC=2.7.1.21;
CC   -!- SIMILARITY: Belongs to the thymidine kinase family. {ECO:0000305}.
DR   EMBL; D00423; BAA00324.1; -; Genomic_DNA.
DR   PIR; B31813; KIVZCP.
DR   ProteinModelPortal; P16600; -.
DR   SMR; P16600; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA synthesis; Kinase; Metal-binding; Nucleotide-binding;
KW   Transferase; Zinc.
FT   CHAIN         1    177       Thymidine kinase.
FT                                /FTId=PRO_0000174929.
FT   NP_BIND      11     18       ATP. {ECO:0000250}.
FT   REGION      157    161       Substrate binding. {ECO:0000250}.
FT   ACT_SITE     83     83       Proton acceptor. {ECO:0000255}.
FT   METAL       138    138       Zinc. {ECO:0000250}.
FT   METAL       141    141       Zinc. {ECO:0000250}.
FT   METAL       170    170       Zinc. {ECO:0000250}.
FT   METAL       173    173       Zinc. {ECO:0000250}.
FT   BINDING     113    113       Substrate; via amide nitrogen.
FT                                {ECO:0000250}.
SQ   SEQUENCE   177 AA;  20447 MW;  093E53E555F8E2C8 CRC64;
     MDYGYIHLII GPMFSGKSTE LIRIVKRYQI AQYKCCVVKY LKDIRYGNSV YTHDNNHVSA
     ISTTLLYDVV DKIMNFDIIG IDEGQFFKDI VSFSENMANM GKIIIIAALD STFQRKEFND
     ILKLIPLSEK VTKLNAVCME CYKDAAFSKR ITKEKEIELI GGKEKYKSVC RKCYFLE
//
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