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Database: UniProt
Entry: P18207
LinkDB: P18207
Original site: P18207 
ID   GLBL_TYLHE              Reviewed;         253 AA.
AC   P18207;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   08-MAY-2019, entry version 70.
DE   RecName: Full=Giant extracellular hemoglobin linker 1 chain;
OS   Tylorrhynchus heterochaetus (Marine worm) (Nereis heterochaeta).
OC   Eukaryota; Metazoa; Lophotrochozoa; Annelida; Polychaeta; Palpata;
OC   Aciculata; Phyllodocida; Nereididae; Tylorrhynchus.
OX   NCBI_TaxID=6361;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2373687;
RA   Suzuki T., Takagi T., Gotoh T.;
RT   "Primary structure of two linker chains of the extracellular
RT   hemoglobin from the polychaete Tylorrhynchus heterochaetus.";
RL   J. Biol. Chem. 265:12168-12177(1990).
CC   -!- FUNCTION: Acts as a linker for the assembly of heme-containing
CC       chains in the construction of giant hemoglobin.
CC   -!- SUBUNIT: Disulfide-linked dimer of identical chains. A model is
CC       proposed for the subunit structure of the Tylorrhynchus
CC       hemoglobin, consisting of 216 polypeptide chains, 192 heme-
CC       containing chains, and 24 linker chains.
DR   PIR; A36564; A36564.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd11673; hemoglobin_linker_C; 1.
DR   CDD; cd00112; LDLa; 1.
DR   InterPro; IPR031639; Eryth_link_C.
DR   InterPro; IPR036153; Eryth_link_C_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   Pfam; PF16915; Eryth_link_C; 1.
DR   SMART; SM00192; LDLa; 1.
DR   SUPFAM; SSF141480; SSF141480; 1.
DR   SUPFAM; SSF57424; SSF57424; 1.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Oxygen transport;
KW   Transport.
FT   CHAIN         1    253       Giant extracellular hemoglobin linker 1
FT                                chain.
FT                                /FTId=PRO_0000087501.
FT   DOMAIN       89    131       LDL-receptor class A.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID     91    105       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID     98    118       {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DISULFID    112    129       {ECO:0000255|PROSITE-ProRule:PRU00124}.
SQ   SEQUENCE   253 AA;  28200 MW;  461EBBD16DF1B805 CRC64;
     GALGDRNGDC ACDRPSPRGY WGGGMTGRSA FADPHIAEGR LANQDARLGT LEEEVDKLQH
     KYDDFIAGKT ARRERFAQLK DRVWGLEAHH CDDDHLSCKD VAFTCIGHNL VCDGHKDCLN
     GHDEDEETCS IAASVGSSFE GQIRQLDTCT KRKPSAFRFI ITNVDVPKYF PQEPHVKATI
     LMTSSKDGHE TQSSLAVDGV YDFTHRKVIL YSPDKDNLIF ECTFPRHDNN HCKGVMKHSG
     GDVCLTFTLE RID
//
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