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Database: UniProt
Entry: P18755
LinkDB: P18755
Original site: P18755 
ID   ETS1A_XENLA             Reviewed;         438 AA.
AC   P18755;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   07-OCT-2020, entry version 114.
DE   RecName: Full=Protein c-ets-1-A;
DE            Short=C-ets-1A;
GN   Name=ets1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=2205841; DOI=10.1093/nar/18.17.5298;
RA   Stiegler P., Wolff C.M., Baltzinger M., Hirzlin J., Senan F., Meyer D.,
RA   Ghysdael J., Stehelin D., Befort N., Remy P.;
RT   "Characterization of Xenopus laevis cDNA clones of the c-ets-1 proto-
RT   oncogene.";
RL   Nucleic Acids Res. 18:5298-5298(1990).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- SUBUNIT: Binds DNA as a homodimer; homodimerization is required for
CC       transcription activation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P14921}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
DR   EMBL; X52692; CAA36919.1; -; mRNA.
DR   PIR; S11225; S11225.
DR   SMR; P18755; -.
DR   PRIDE; P18755; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR   GO; GO:0045648; P:positive regulation of erythrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB.
DR   CDD; cd08542; SAM_PNT-ETS-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041886; SAM_PNT-ETS-1.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Phosphoprotein; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..438
FT                   /note="Protein c-ets-1-A"
FT                   /id="PRO_0000204074"
FT   DOMAIN          49..134
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        332..412
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          128..240
FT                   /note="Activation domain; required for transcription
FT                   activation"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         153
FT                   /note="Phosphoserine; by CaMK"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         279
FT                   /note="Phosphoserine; by CaMK"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   438 AA;  50268 MW;  B97A8EBDF2DB51FA CRC64;
     MKAALDLKPT LSIKTEKEYE AYSCSDMECA DVPLLTPSSK EMMSQALRAT FSRFTKEQQR
     LGIPIDPREW TDMHVREWVS WAVNEFTLKG VDFQKFCMSG AALCALGKEC FLELAPDFVG
     DILWEHLEIL QKDSKQYQTS EITPAYPESR YTSDYFISYG IEHAQCVPPS EFSEPSFITE
     SYQTLHPISS EELLSLKYEN DYPLGLLRDP LQPESLQGDY FTIKQEVVTP DNMCLGRISR
     GKLGGQESFE SIESHDSCDR LTQSWSSQSS YNSLQRVPSY DSFDSEDYPP AMPSHKSKGT
     FKDYVRDRAE LNKDKPVIPA AALAGYTGSG PIQLWQFLLE LLTDKSCQSF ISWTGDGWEF
     KLSDPDEVAR RWGKRKNKPK MNYEKLSRGL RYYYDKNIIH KTAGKRYVYR FVCDLQSLLG
     YVPEELHAML DVKPDTDE
//
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