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Database: UniProt
Entry: P20267
LinkDB: P20267
Original site: P20267 
ID   PO3F1_RAT               Reviewed;         451 AA.
AC   P20267;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 2.
DT   24-JAN-2024, entry version 165.
DE   RecName: Full=POU domain, class 3, transcription factor 1;
DE   AltName: Full=Octamer-binding protein 6;
DE            Short=Oct-6;
DE   AltName: Full=Octamer-binding transcription factor 6;
DE            Short=OTF-6;
DE   AltName: Full=POU domain transcription factor SCIP;
DE   AltName: Full=Tst-1;
GN   Name=Pou3f1; Synonyms=Oct-6, Otf-6, Otf6, Scip;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION BY INJURY.
RX   PubMed=1975954; DOI=10.1126/science.1975954;
RA   Monuki E.S., Kuhn R., Weinmaster G., Trapp B.D., Lemke G.;
RT   "Expression and activity of the POU transcription factor SCIP.";
RL   Science 249:1300-1303(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 265-369.
RX   PubMed=2739723; DOI=10.1038/340035a0;
RA   He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W.,
RA   Rosenfeld M.G.;
RT   "Expression of a large family of POU-domain regulatory genes in mammalian
RT   brain development.";
RL   Nature 340:35-42(1989).
RN   [3]
RP   ERRATUM OF PUBMED:2739723, AND SEQUENCE REVISION TO 320.
RA   He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W.,
RA   Rosenfeld M.G.;
RL   Nature 340:662-662(1989).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 35-451.
RX   PubMed=1705013; DOI=10.1128/mcb.11.3.1739-1744.1991;
RA   He X., Gerrero M.R., Simmons D.M., Park R.E., Lin C.R., Swanson L.W.,
RA   Rosenfeld M.G.;
RT   "Tst-1, a member of the POU domain gene family, binds the promoter of the
RT   gene encoding the cell surface adhesion molecule P0.";
RL   Mol. Cell. Biol. 11:1739-1744(1991).
CC   -!- FUNCTION: Transcription factor that binds to the octamer motif (5'-
CC       ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when
CC       binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By
CC       similarity). Acts as a transcriptional repressor of myelin-specific
CC       genes (PubMed:1975954). {ECO:0000250|UniProtKB:P21952,
CC       ECO:0000269|PubMed:1975954}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P21952}.
CC   -!- TISSUE SPECIFICITY: Neural tissues and testis.
CC   -!- INDUCTION: Transiently increased in rapidly dividing Schwann cells in
CC       response to sciatic nerve transection 2 days post-injury.
CC       {ECO:0000269|PubMed:1975954}.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M72711; AAA42118.1; -; mRNA.
DR   EMBL; M63712; AAA42303.1; -; mRNA.
DR   PIR; A40168; A40168.
DR   RefSeq; NP_620193.1; NM_138838.1.
DR   AlphaFoldDB; P20267; -.
DR   SMR; P20267; -.
DR   GlyGen; P20267; 1 site, 1 O-linked glycan (1 site).
DR   PhosphoSitePlus; P20267; -.
DR   GeneID; 192110; -.
DR   KEGG; rno:192110; -.
DR   UCSC; RGD:619767; rat.
DR   AGR; RGD:619767; -.
DR   CTD; 5453; -.
DR   RGD; 619767; Pou3f1.
DR   InParanoid; P20267; -.
DR   OrthoDB; 4250502at2759; -.
DR   PhylomeDB; P20267; -.
DR   PRO; PR:P20267; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; ISO:RGD.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:MGI.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0008544; P:epidermis development; ISO:RGD.
DR   GO; GO:0030900; P:forebrain development; ISO:RGD.
DR   GO; GO:0010001; P:glial cell differentiation; IDA:RGD.
DR   GO; GO:0030216; P:keratinocyte differentiation; ISO:RGD.
DR   GO; GO:0042552; P:myelination; ISO:RGD.
DR   GO; GO:0022011; P:myelination in peripheral nervous system; ISO:RGD.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IDA:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IDA:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0014044; P:Schwann cell development; ISO:RGD.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   InterPro; IPR016362; TF_POU_3.
DR   PANTHER; PTHR11636; POU DOMAIN; 1.
DR   PANTHER; PTHR11636:SF75; POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 1; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PIRSF; PIRSF002629; Transcription_factor_POU; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..451
FT                   /note="POU domain, class 3, transcription factor 1"
FT                   /id="PRO_0000100722"
FT   DOMAIN          247..321
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        339..398
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          395..451
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..451
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        423
FT                   /note="S -> G (in Ref. 4; AAA42118/AAA42303)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   451 AA;  45496 MW;  E32626A759125EAA CRC64;
     MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ KLMHHEWLGA
     GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGST GRADDGGGGG GFHARLVHQG
     AAHAGAAWAQ GGTAHHLGPA MSPSPGAGGG HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG
     GGAGPGLHHA LHEDGHEAQL EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS
     VGEHSDEDAP SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ
     LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV KGALESHFLK
     CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA AGAGHPPMDD VYAPGELGPG
     GGSASPPSAP PPPPPAALHH HHHHTLPGSV Q
//
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