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Database: UniProt
Entry: P20736
LinkDB: P20736
Original site: P20736 
ID   BM86_RHIMP              Reviewed;         650 AA.
AC   P20736;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-MAY-2018, entry version 82.
DE   RecName: Full=Glycoprotein antigen BM86;
DE   AltName: Full=Protective antigen;
DE   Flags: Precursor;
OS   Rhipicephalus microplus (Cattle tick) (Boophilus microplus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Acari; Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae;
OC   Rhipicephalus; Boophilus.
OX   NCBI_TaxID=6941;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Gut;
RX   PubMed=2690068; DOI=10.1073/pnas.86.24.9657;
RA   Rand K.N., Moore T., Sriskantha A., Spring K., Tellam R.L.,
RA   Willadsen P., Cobon G.S.;
RT   "Cloning and expression of a protective antigen from the cattle tick
RT   Boophilus microplus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:9657-9661(1989).
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE.
RX   PubMed=2745982;
RA   Willadsen P., Riding G.A., McKenna R.V., Kemp D.H., Tellam R.L.,
RA   Nielsen J.N., Lahnstein J., Cobon G.S., Gough J.M.;
RT   "Immunologic control of a parasitic arthropod. Identification of a
RT   protective antigen from Boophilus microplus.";
RL   J. Immunol. 143:1346-1351(1989).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor,
CC       GPI-anchor {ECO:0000305}.
DR   EMBL; M29321; AAA30098.1; -; mRNA.
DR   PIR; A34498; A34498.
DR   ProteinModelPortal; P20736; -.
DR   SMR; P20736; -.
DR   PRIDE; P20736; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000742; EGF-like_dom.
DR   SMART; SM00181; EGF; 4.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Disulfide bond;
KW   EGF-like domain; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Repeat; Signal.
FT   SIGNAL        1     19
FT   CHAIN        20    627       Glycoprotein antigen BM86.
FT                                /FTId=PRO_0000007486.
FT   PROPEP      628    650       Removed in mature form. {ECO:0000250}.
FT                                /FTId=PRO_0000007487.
FT   DOMAIN       20     66       EGF-like 1.
FT   DOMAIN       67    104       EGF-like 2.
FT   DOMAIN      205    247       EGF-like 3.
FT   DOMAIN      251    292       EGF-like 4.
FT   DOMAIN      291    335       EGF-like 5.
FT   DOMAIN      482    530       EGF-like 6.
FT   DOMAIN      531    568       EGF-like 7.
FT   COMPBIAS    601    627       Ser/Thr-rich.
FT   LIPID       627    627       GPI-anchor amidated serine.
FT                                {ECO:0000250}.
FT   CARBOHYD    141    141       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    182    182       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    348    348       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    382    382       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     24     37       {ECO:0000250}.
FT   DISULFID     32     49       {ECO:0000250}.
FT   DISULFID     51     65       {ECO:0000250}.
FT   DISULFID     71     81       {ECO:0000250}.
FT   DISULFID     76     91       {ECO:0000250}.
FT   DISULFID     93    103       {ECO:0000250}.
FT   DISULFID    209    222       {ECO:0000250}.
FT   DISULFID    218    231       {ECO:0000250}.
FT   DISULFID    233    246       {ECO:0000250}.
FT   DISULFID    255    269       {ECO:0000250}.
FT   DISULFID    263    278       {ECO:0000250}.
FT   DISULFID    280    291       {ECO:0000250}.
FT   DISULFID    295    307       {ECO:0000250}.
FT   DISULFID    300    316       {ECO:0000250}.
FT   DISULFID    318    334       {ECO:0000250}.
FT   DISULFID    486    500       {ECO:0000250}.
FT   DISULFID    492    516       {ECO:0000250}.
FT   DISULFID    518    529       {ECO:0000250}.
FT   DISULFID    535    550       {ECO:0000250}.
FT   DISULFID    543    559       {ECO:0000250}.
FT   DISULFID    561    567       {ECO:0000250}.
FT   VARIANT     235    237       SGS -> RAF.
FT   VARIANT     507    507       F -> C.
SQ   SEQUENCE   650 AA;  71722 MW;  5DED71E354D8312A CRC64;
     MRGIALFVAA VSLIVEGTAE SSICSDFGNE FCRNAECEVV PGAEDDFVCK CPRDNMYFNA
     AEKQCEYKDT CKTRECSYGR CVESNPSKAS CVCEASDDLT LQCKIKNDYA TDCRNRGGTA
     KLRTDGFIGA TCDCGEWGAM NMTTRNCVPT TCLRPDLTCK DLCEKNLLQR DSRCCQGWNT
     ANCSAAPPAD SYCSPGSPKG PDGQCINACK TKEAGFVCKH GCRSTGKAYE CTCPSGSTVA
     EDGITCKSIS HTVSCTAEQK QTCRPTEDCR VHKGTVLCEC PWNQHLVGDT CISDCVDKKC
     HEEFMDCGVY MNRQSCYCPW KSRKPGPNVN INECLLNEYY YTVSFTPNIS FDSDHCKWYE
     DRVLEAIRTS IGKEVFKVEI LNCTQDIKAR LIAEKPLSKH VLRKLQACEH PIGEWCMMYP
     KLLIKKNSAT EIEEENLCDS LLKDQEAAYK GQNKCVKVDN LFWFQCADGY TTTYEMTRGR
     LRRSVCKAGV SCNENEQSEC ADKGQIFVYE NGKANCQCPP DTKPGEIGCI ERTTCNPKEI
     QECQDKKLEC VYKNHKAECE CPDDHECYRE PAKDSCSEED NGKCQSSGQR CVIENGKAVC
     KEKSEATTAA TTTTKAKDKD PDPGKSSAAA VSATGLLLLL AATSVTAASL
//
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