ID B4_USTMD Reviewed; 410 AA.
AC P22018;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 22-FEB-2023, entry version 86.
DE RecName: Full=Mating-type locus allele B4 protein;
OS Ustilago maydis (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=5270;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RK138;
RX PubMed=1967554; DOI=10.1016/0092-8674(90)90744-y;
RA Schulz B., Banuett F., Dahl M., Schlesinger R., Schaefer W., Martin T.,
RA Herskowitz I., Kahmann R.;
RT "The b alleles of U. maydis, whose combinations program pathogenic
RT development, code for polypeptides containing a homeodomain-related
RT motif.";
RL Cell 60:295-306(1990).
CC -!- FUNCTION: The B locus has at least 25 alleles, and any combination of
CC two different B alleles yields a multimeric regulatory protein, that
CC activates genes responsible for the pathogenicity and for the sexual
CC development of the fungus within the corn plant.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the TALE/M-ATYP homeobox family. {ECO:0000305}.
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DR EMBL; M58556; AAA63556.1; -; Genomic_DNA.
DR PIR; C32696; C32696.
DR AlphaFoldDB; P22018; -.
DR SMR; P22018; -.
DR VEuPathDB; FungiDB:UMAG_12052; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR008888; Ustilago_mating.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF05722; Ustilago_mating; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Homeobox; Nucleus.
FT CHAIN 1..410
FT /note="Mating-type locus allele B4 protein"
FT /id="PRO_0000049404"
FT DNA_BIND 107..184
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..110
FT /note="Variable domain between B alleles"
FT REGION 111..410
FT /note="Highly conserved between B alleles"
FT REGION 202..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..410
FT /note="Not essential for B4 function"
FT REGION 375..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 276..308
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 202..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 46061 MW; D4B1C36E5C702291 CRC64;
MSSDPKISIT SFLECLSEIE EEFLRDKEKN PPVLVSKLQE LQQKTPNNIA NLDHDPETIQ
KIHQTTHRIN VAVKAFICID QTFVSLRSDA VEDASRALKK ANASSPVVGC RELSEDLPAY
HMRKHFLHTL ENPYPTQEEK ETLVRLTNES TARVGQSIVN RPPLEVHQLT LWFINARRRS
GWSHILKKFA REDRSRMKHL VRAKLSSSNQ STPPSPTSEY PSNNLDDFLS DNLGRPLTPA
DKQQFEDDWA SMISWIKYGV KEKVGDWVYD LCAASKKTPK PGMPRPVTTV AKRQPARKTK
PAAKPKSRTA NPRASTTPSI DSTLDSSKLE STPELSMCST ADTSFSTFGS SLSMSHYDPF
QYGNDILQSP TFKARGNRKV KALPKRAGKQ QPDEVENGKI PFLCLSVAFV
//
