ID BAGP_DROME Reviewed; 382 AA.
AC P22809; Q24254; Q6UJA4; Q6UJA5; Q6UJA8; Q6UJA9; Q6UJB1; Q6UJB2; Q9VDA6;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 3.
DT 24-JAN-2024, entry version 170.
DE RecName: Full=Homeobox protein bagpipe;
DE AltName: Full=Homeobox protein NK-3;
GN Name=bap; Synonyms=bgp, NK3; ORFNames=CG7902;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=8101173; DOI=10.1101/gad.7.7b.1325;
RA Azpiazu N., Frasch M.;
RT "Tinman and bagpipe: two homeo box genes that determine cell fates in the
RT dorsal mesoderm of Drosophila.";
RL Genes Dev. 7:1325-1340(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=F-1461S, F-274F, F-357F, F-517F, F-517S, F-531F, F-611F, F-775F,
RC F-96S, S-114S, S-1224F, S-174F, S-255S, S-2588S, S-26F, S-377F, S-438S,
RC S-501F, S-501S, S-510S, S-521F, S-521S, S-549S, S-565F, S-581F, S-94F,
RC S-968F, and US-255F;
RX PubMed=15126403; DOI=10.1534/genetics.166.4.1845;
RA Balakirev E.S., Ayala F.J.;
RT "Nucleotide variation in the tinman and bagpipe homeobox genes of
RT Drosophila melanogaster.";
RL Genetics 166:1845-1856(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-288.
RC STRAIN=Canton-S;
RX PubMed=2573058; DOI=10.1073/pnas.86.20.7716;
RA Kim Y., Nirenberg M.;
RT "Drosophila NK-homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:7716-7720(1989).
CC -!- FUNCTION: Involved in the determination of cell fates in the dorsal
CC mesoderm. {ECO:0000269|PubMed:8101173}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Is expressed in a segmented pattern in visceral
CC muscle and in a subset of cardiac muscles. Loss of activity results in
CC segmental gaps in midgut visceral muscle. {ECO:0000269|PubMed:8101173}.
CC -!- SIMILARITY: Belongs to the NK-3 homeobox family. {ECO:0000305}.
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DR EMBL; L17133; AAC37165.1; -; mRNA.
DR EMBL; AY369088; AAQ73793.1; -; Genomic_DNA.
DR EMBL; AY369089; AAQ73794.1; -; Genomic_DNA.
DR EMBL; AY369090; AAQ73795.1; -; Genomic_DNA.
DR EMBL; AY369091; AAQ73796.1; -; Genomic_DNA.
DR EMBL; AY369092; AAQ73797.1; -; Genomic_DNA.
DR EMBL; AY369093; AAQ73798.1; -; Genomic_DNA.
DR EMBL; AY369094; AAQ73799.1; -; Genomic_DNA.
DR EMBL; AY369095; AAQ73800.1; -; Genomic_DNA.
DR EMBL; AY369096; AAQ73801.1; -; Genomic_DNA.
DR EMBL; AY369097; AAQ73802.1; -; Genomic_DNA.
DR EMBL; AY369098; AAQ73803.1; -; Genomic_DNA.
DR EMBL; AY369099; AAQ73804.1; -; Genomic_DNA.
DR EMBL; AY369100; AAQ73805.1; -; Genomic_DNA.
DR EMBL; AY369101; AAQ73806.1; -; Genomic_DNA.
DR EMBL; AY369102; AAQ73807.1; -; Genomic_DNA.
DR EMBL; AY369103; AAQ73808.1; -; Genomic_DNA.
DR EMBL; AY369104; AAQ73809.1; -; Genomic_DNA.
DR EMBL; AY369105; AAQ73810.1; -; Genomic_DNA.
DR EMBL; AY369106; AAQ73811.1; -; Genomic_DNA.
DR EMBL; AY369107; AAQ73812.1; -; Genomic_DNA.
DR EMBL; AY369108; AAQ73813.1; -; Genomic_DNA.
DR EMBL; AY369109; AAQ73814.1; -; Genomic_DNA.
DR EMBL; AY369110; AAQ73815.1; -; Genomic_DNA.
DR EMBL; AY369111; AAQ73816.1; -; Genomic_DNA.
DR EMBL; AY369112; AAQ73817.1; -; Genomic_DNA.
DR EMBL; AY369113; AAQ73818.1; -; Genomic_DNA.
DR EMBL; AY369114; AAQ73819.1; -; Genomic_DNA.
DR EMBL; AY369115; AAQ73820.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF55891.1; -; Genomic_DNA.
DR EMBL; M27291; AAA28618.1; -; Genomic_DNA.
DR PIR; C33976; C33976.
DR RefSeq; NP_732637.1; NM_169958.2.
DR AlphaFoldDB; P22809; -.
DR SMR; P22809; -.
DR BioGRID; 67503; 17.
DR IntAct; P22809; 11.
DR STRING; 7227.FBpp0083486; -.
DR PaxDb; 7227-FBpp0083486; -.
DR EnsemblMetazoa; FBtr0084087; FBpp0083486; FBgn0004862.
DR GeneID; 42537; -.
DR KEGG; dme:Dmel_CG7902; -.
DR UCSC; CG7902-RA; d. melanogaster.
DR AGR; FB:FBgn0004862; -.
DR CTD; 42537; -.
DR FlyBase; FBgn0004862; bap.
DR VEuPathDB; VectorBase:FBgn0004862; -.
DR eggNOG; KOG0842; Eukaryota.
DR HOGENOM; CLU_044250_0_0_1; -.
DR InParanoid; P22809; -.
DR OMA; YAHMAAP; -.
DR OrthoDB; 461623at2759; -.
DR PhylomeDB; P22809; -.
DR SignaLink; P22809; -.
DR BioGRID-ORCS; 42537; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 42537; -.
DR PRO; PR:P22809; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0004862; Expressed in crop (Drosophila) and 15 other cell types or tissues.
DR ExpressionAtlas; P22809; baseline and differential.
DR Genevisible; P22809; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IGI:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007498; P:mesoderm development; IEP:FlyBase.
DR GO; GO:0001710; P:mesodermal cell fate commitment; TAS:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0007522; P:visceral muscle development; NAS:FlyBase.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR24340:SF73; HOMEOBOX PROTEIN BAGPIPE; 1.
DR PANTHER; PTHR24340; HOMEOBOX PROTEIN NKX; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..382
FT /note="Homeobox protein bagpipe"
FT /id="PRO_0000049016"
FT DNA_BIND 175..234
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 27..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 62
FT /note="I -> A (in strain: F-96S, F-274F, S-26F, S-94F, S-
FT 377F, S-510S, S-521F, S-521S, S-565F, S-968F and US-255F)"
FT VARIANT 62
FT /note="I -> V (in strain: F-775F, S-549S and S-1224F)"
FT VARIANT 74
FT /note="G -> S (in strain: F-775F, S-549S and S-1224F)"
FT VARIANT 327
FT /note="T -> N (in strain: S-26F, S-94F, S-438S, S-510S and
FT S-521F)"
FT VARIANT 342
FT /note="G -> S (in strain: S-26F, S-94F, S-438S, S-510S and
FT S-521F)"
FT VARIANT 367
FT /note="S -> SGAES (in strain: S-521S, S-968F and US-255F)"
FT VARIANT 369
FT /note="H -> Q (in strain: F-611F)"
FT CONFLICT 251
FT /note="V -> I (in Ref. 1; AAC37165)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 382 AA; 41993 MW; 49A8DFE19A2022B9 CRC64;
MLNMESAGVS AAMAGLSKSL TTPFSINDIL TRSNPETRRM SSVDSEPEPE KLKPSSDRER
SISKSPPLCC RDLGLYKLTQ PKEIQPSARQ PSNYLQYYAA AMDNNNHHHQ ATGTSNSSAA
DYMQRKLAYF GSTLAAPLDM RRCTSNDSDC DSPPPLSSSP SESPLSHDGS GLSRKKRSRA
AFSHAQVFEL ERRFAQQRYL SGPERSEMAK SLRLTETQVK IWFQNRRYKT KRKQIQQHEA
ALLGASKRVP VQVLVREDGS TTYAHMAAPG AGHGLDPALI NIYRHQLQLA YGGLPLPQMQ
MPFPYFYPQH KVPQPIPPPT QSSSFVTASS ASSSPVPIPI PGAVRPQRTP CPSPNGQMMS
VESGAESVHS AAEDVDENVE ID
//
