ID HRH2_RAT Reviewed; 358 AA.
AC P25102;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 27-MAR-2024, entry version 144.
DE RecName: Full=Histamine H2 receptor;
DE Short=H2R;
DE Short=HH2R;
DE AltName: Full=Gastric receptor I;
GN Name=Hrh2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1930188; DOI=10.1016/0006-291x(91)91738-x;
RA Ruat M., Traiffort E., Arrang J.-M., Leurs R., Schwartz J.-C.;
RT "Cloning and tissue expression of a rat histamine H2-receptor gene.";
RL Biochem. Biophys. Res. Commun. 179:1470-1478(1991).
CC -!- FUNCTION: The H2 subclass of histamine receptors mediates gastric acid
CC secretion. The activity of this receptor is mediated by G proteins
CC which activate adenylyl cyclase.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; S57565; AAB19935.1; -; Genomic_DNA.
DR PIR; JQ1278; JQ1278.
DR RefSeq; NP_037097.3; NM_012965.3.
DR AlphaFoldDB; P25102; -.
DR SMR; P25102; -.
DR IntAct; P25102; 2.
DR STRING; 10116.ENSRNOP00000024580; -.
DR BindingDB; P25102; -.
DR ChEMBL; CHEMBL4654; -.
DR DrugCentral; P25102; -.
DR GuidetoPHARMACOLOGY; 263; -.
DR GlyCosmos; P25102; 1 site, No reported glycans.
DR GlyGen; P25102; 1 site.
DR PhosphoSitePlus; P25102; -.
DR PaxDb; 10116-ENSRNOP00000024580; -.
DR KEGG; rno:25461; -.
DR AGR; RGD:2831; -.
DR CTD; 3274; -.
DR RGD; 2831; Hrh2.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P25102; -.
DR OrthoDB; 2900736at2759; -.
DR PhylomeDB; P25102; -.
DR Reactome; R-RNO-390650; Histamine receptors.
DR PRO; PR:P25102; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:1901363; F:heterocyclic compound binding; IDA:RGD.
DR GO; GO:0004969; F:histamine receptor activity; IDA:RGD.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0071420; P:cellular response to histamine; IEP:RGD.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0048565; P:digestive tract development; ISO:RGD.
DR GO; GO:0003382; P:epithelial cell morphogenesis; ISO:RGD.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0001696; P:gastric acid secretion; ISO:RGD.
DR GO; GO:0001698; P:gastrin-induced gastric acid secretion; ISO:RGD.
DR GO; GO:0048732; P:gland development; ISO:RGD.
DR GO; GO:0001697; P:histamine-induced gastric acid secretion; ISO:RGD.
DR GO; GO:0007613; P:memory; ISO:RGD.
DR GO; GO:1900139; P:negative regulation of arachidonic acid secretion; IDA:RGD.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0048167; P:regulation of synaptic plasticity; ISO:RGD.
DR GO; GO:0008542; P:visual learning; ISO:RGD.
DR CDD; cd15051; 7tmA_Histamine_H2R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000503; Histamine_H2_rcpt.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF276; HISTAMINE H2 RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00531; HISTAMINEH2R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..358
FT /note="Histamine H2 receptor"
FT /id="PRO_0000069688"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..92
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..203
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..288
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT SITE 98
FT /note="Essential for histamine binding"
FT /evidence="ECO:0000250"
FT SITE 185
FT /note="Essential for tiotidine binding and implicated in
FT histamine binding"
FT /evidence="ECO:0000250"
FT SITE 189
FT /note="Implicated in histamine binding"
FT /evidence="ECO:0000250"
FT LIPID 304
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 91..173
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 358 AA; 40253 MW; 4889F69B7B5D5DDC CRC64;
MEPNGTVHSC CLDSMALKVT ISVVLTTLIL ITIAGNVVVC LAVSLNRRLR SLTNCFIVSL
AATDLLLGLL VLPFSAIYQL SFTWSFGHVF CNIYTSLDVM LCTASILNLF MISLDRYCAV
TDPLRYPVLV TPVRVAISLV FIWVISITLS FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV
YGLVDGLVTF YLPLLIMCVT YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG
AFIICWFPYF TAFVYRGLRG DDAINEAVEG IVLWLGYANS ALNPILYAAL NRDFRTAYQQ
LFHCKFASHN SHKTSLRLNN SLLPRSQSRE GRWQEEKPLK LQVWSGTELT HPQGNPIR
//
