GenomeNet

Database: UniProt
Entry: P26323
LinkDB: P26323
Original site: P26323 
ID   FLI1_MOUSE              Reviewed;         452 AA.
AC   P26323;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   07-OCT-2020, entry version 174.
DE   RecName: Full=Friend leukemia integration 1 transcription factor;
DE   AltName: Full=Retroviral integration site protein Fli-1;
GN   Name=Fli1; Synonyms=Fli-1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INVOLVEMENT IN ERYTHROLEUKEMIA.
RC   STRAIN=BALB/cJ; TISSUE=Spleen;
RX   PubMed=2044959; DOI=10.1101/gad.5.6.908;
RA   Ben-David Y., Giddens E.B., Letwin K., Bernstein A.;
RT   "Erythroleukemia induction by Friend murine leukemia virus: insertional
RT   activation of a new member of the ets gene family, Fli-1, closely linked to
RT   c-ets-1.";
RL   Genes Dev. 5:908-918(1991).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=8502483;
RA   Zhang L., Lemarchandel V., Romeo P.-H., Ben-David Y., Greer P.,
RA   Bernstein A.;
RT   "The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma,
RT   encodes a transcriptional activator with DNA-binding specificities distinct
RT   from other Ets family members.";
RL   Oncogene 8:1621-1630(1993).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Sequence-specific transcriptional activator. Recognizes the
CC       DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000250|UniProtKB:Q01543}.
CC   -!- SUBUNIT: Can form homodimers or heterodimers with ETV6/TEL1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q01543}.
CC   -!- TISSUE SPECIFICITY: Expressed in both hematopoietic and
CC       nonhematopoietic tissues.
CC   -!- INDUCTION: Specifically up-regulated in leukemic clones with F-MuLV
CC       insertions up-stream of the FLI-1 locus.
CC   -!- DISEASE: Note=Involved in erythroleukemia induction by Friend murine
CC       leukemia virus (F-MULV). {ECO:0000269|PubMed:2044959}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
DR   EMBL; X59421; CAA42055.1; -; mRNA.
DR   CCDS; CCDS40571.1; -.
DR   PIR; S17403; S17403.
DR   RefSeq; NP_032052.1; NM_008026.5.
DR   BMRB; P26323; -.
DR   SMR; P26323; -.
DR   BioGRID; 199702; 2.
DR   IntAct; P26323; 2.
DR   STRING; 10090.ENSMUSP00000016231; -.
DR   iPTMnet; P26323; -.
DR   PhosphoSitePlus; P26323; -.
DR   EPD; P26323; -.
DR   jPOST; P26323; -.
DR   PaxDb; P26323; -.
DR   PeptideAtlas; P26323; -.
DR   PRIDE; P26323; -.
DR   ABCD; P26323; 85 sequenced antibodies.
DR   Antibodypedia; 9350; 656 antibodies.
DR   Ensembl; ENSMUST00000016231; ENSMUSP00000016231; ENSMUSG00000016087.
DR   GeneID; 14247; -.
DR   KEGG; mmu:14247; -.
DR   UCSC; uc009orz.2; mouse.
DR   CTD; 2313; -.
DR   MGI; MGI:95554; Fli1.
DR   eggNOG; KOG3806; Eukaryota.
DR   GeneTree; ENSGT00940000158261; -.
DR   HOGENOM; CLU_045216_0_1_1; -.
DR   InParanoid; P26323; -.
DR   KO; K09436; -.
DR   OMA; TAFFQNM; -.
DR   OrthoDB; 1113327at2759; -.
DR   PhylomeDB; P26323; -.
DR   TreeFam; TF350537; -.
DR   BioGRID-ORCS; 14247; 6 hits in 20 CRISPR screens.
DR   ChiTaRS; Fli1; mouse.
DR   PRO; PR:P26323; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; P26323; protein.
DR   Bgee; ENSMUSG00000016087; Expressed in pineal body and 278 other tissues.
DR   ExpressionAtlas; P26323; baseline and differential.
DR   Genevisible; P26323; MM.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0042025; C:host cell nucleus; IEA:InterPro.
DR   GO; GO:0016604; C:nuclear body; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0009887; P:animal organ morphogenesis; IMP:MGI.
DR   GO; GO:0008015; P:blood circulation; IMP:MGI.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0009987; P:cellular process; TAS:MGI.
DR   GO; GO:0035855; P:megakaryocyte development; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:MGI.
DR   CDD; cd08541; SAM_PNT-FLI-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR035575; Fli-1.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR035573; SAM_PNT-FLI-1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849:SF161; PTHR11849:SF161; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..452
FT                   /note="Friend leukemia integration 1 transcription factor"
FT                   /id="PRO_0000204125"
FT   DOMAIN          112..198
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        281..361
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   MOD_RES         39
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:21183079"
SQ   SEQUENCE   452 AA;  51002 MW;  1F9A06C6893FE2AB CRC64;
     MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP LPPQQEWINQ
     PVRVNVKREY DHMNGSRESP VDCSVSKCNK LVGGGEANPM NYNSYMDEKN GPPPPNMTTN
     ERRVIVPADP TLWTQEHVRQ WLEWAIKEYG LMEIDTSFFQ NMDGKELCKM NKEDFLRATS
     AYNTEVLLSH LSYLRESSLL AYNTTSHTDQ SSRLNVKEDP SYDSVRRGAW NNNMNSGLNK
     SPLLGGSQTM GKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI
     TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK VHGKRYAYKF
     DFHGIAQALQ PHPTETSMYK YPSDISYMPS YHAHQQKVNF VPSHPSSMPV TSSSFFGAAS
     QYWTSPTAGI YPNPSVPRHP NTHVPSHLGS YY
//
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