GenomeNet

Database: UniProt
Entry: P26371
LinkDB: P26371
Original site: P26371 
ID   KRA59_HUMAN             Reviewed;         169 AA.
AC   P26371; Q14564; Q3MIP8;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   18-SEP-2019, entry version 136.
DE   RecName: Full=Keratin-associated protein 5-9;
DE   AltName: Full=Keratin, cuticle, ultrahigh sulfur 1;
DE   AltName: Full=Keratin, ultra high-sulfur matrix protein A;
DE   AltName: Full=Keratin-associated protein 5.9;
DE   AltName: Full=UHS keratin A;
DE            Short=UHS KerA;
DE   AltName: Full=Ultrahigh sulfur keratin-associated protein 5.9;
GN   Name=KRTAP5-9; Synonyms=KAP5.9, KRN1, KRTAP5.9, UHSK1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Hair follicle;
RX   PubMed=1703541; DOI=10.1083/jcb.111.6.2587;
RA   McKinnon P.J., Powell B.C., Rogers G.E.;
RT   "Structure and expression of genes for a class of cysteine-rich
RT   proteins of the cuticle layers of differentiating wool and hair
RT   follicles.";
RL   J. Cell Biol. 111:2587-2600(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10023043; DOI=10.1016/s0378-1119(98)00616-7;
RA   Perez C., Auriol J., Gerst C., Bernard B.A., Egly J.-M.;
RT   "Genomic organization and promoter characterization of two human UHS
RT   keratin genes.";
RL   Gene 227:137-148(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT CYS-40.
RC   TISSUE=Testis;
RA   Drabent B., Doenecke D.;
RL   Submitted (DEC-1991) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Hair root;
RX   PubMed=15144888; DOI=10.1016/j.bbrc.2004.04.074;
RA   Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J.,
RA   Shimizu N.;
RT   "Identification of two novel clusters of ultrahigh-sulfur keratin-
RT   associated protein genes on human chromosome 11.";
RL   Biochem. Biophys. Res. Commun. 318:655-664(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
CC       are embedded in an interfilamentous matrix, consisting of hair
CC       keratin-associated protein (KRTAP), which are essential for the
CC       formation of a rigid and resistant hair shaft through their
CC       extensive disulfide bond cross-linking with abundant cysteine
CC       residues of hair keratins. The matrix proteins include the high-
CC       sulfur and high-glycine-tyrosine keratins.
CC   -!- SUBUNIT: Interacts with hair keratins.
CC   -!- INTERACTION:
CC       Q5BKY6:-; NbExp=3; IntAct=EBI-3958099, EBI-10243533;
CC       Q9NWL9:-; NbExp=3; IntAct=EBI-3958099, EBI-10315054;
CC       Q6UY14-3:ADAMTSL4; NbExp=9; IntAct=EBI-3958099, EBI-10173507;
CC       P05187:ALPP; NbExp=5; IntAct=EBI-3958099, EBI-1211484;
CC       Q7Z3C6:ATG9A; NbExp=3; IntAct=EBI-3958099, EBI-727146;
CC       Q9BXY8:BEX2; NbExp=3; IntAct=EBI-3958099, EBI-745073;
CC       A8K571:BMP7; NbExp=3; IntAct=EBI-3958099, EBI-10174327;
CC       Q5T681:C10orf62; NbExp=3; IntAct=EBI-3958099, EBI-744052;
CC       Q6NUJ2:C11orf87; NbExp=3; IntAct=EBI-3958099, EBI-6660291;
CC       Q8NEC5:CATSPER1; NbExp=7; IntAct=EBI-3958099, EBI-744545;
CC       Q9UKJ5:CHIC2; NbExp=5; IntAct=EBI-3958099, EBI-741528;
CC       Q9H2X0:CHRD; NbExp=5; IntAct=EBI-3958099, EBI-947551;
CC       P61024:CKS1B; NbExp=3; IntAct=EBI-3958099, EBI-456371;
CC       Q8NE01:CNNM3; NbExp=5; IntAct=EBI-3958099, EBI-741032;
CC       P21964-2:COMT; NbExp=3; IntAct=EBI-3958099, EBI-10200977;
CC       Q9UGL9:CRCT1; NbExp=5; IntAct=EBI-3958099, EBI-713677;
CC       Q9UBR2:CTSZ; NbExp=6; IntAct=EBI-3958099, EBI-8636823;
CC       A8MQ03:CYSRT1; NbExp=4; IntAct=EBI-3958099, EBI-3867333;
CC       Q96LJ7:DHRS1; NbExp=3; IntAct=EBI-3958099, EBI-746300;
CC       Q9NQL9:DMRT3; NbExp=3; IntAct=EBI-3958099, EBI-9679045;
CC       Q92608:DOCK2; NbExp=5; IntAct=EBI-3958099, EBI-448771;
CC       P16930:FAH; NbExp=3; IntAct=EBI-3958099, EBI-4397076;
CC       Q9H5Z6:FAM124B; NbExp=3; IntAct=EBI-3958099, EBI-741626;
CC       Q3B820:FAM161A; NbExp=5; IntAct=EBI-3958099, EBI-719941;
CC       Q5TZK3:FAM74A6; NbExp=5; IntAct=EBI-3958099, EBI-10247271;
CC       Q5HYJ3:FAM76B; NbExp=3; IntAct=EBI-3958099, EBI-751192;
CC       O76003:GLRX3; NbExp=7; IntAct=EBI-3958099, EBI-374781;
CC       Q9Y223:GNE; NbExp=3; IntAct=EBI-3958099, EBI-4291090;
CC       P49639:HOXA1; NbExp=9; IntAct=EBI-3958099, EBI-740785;
CC       P09022:Hoxa1 (xeno); NbExp=3; IntAct=EBI-3958099, EBI-3957603;
CC       P17482:HOXB9; NbExp=3; IntAct=EBI-3958099, EBI-745290;
CC       P37235:HPCAL1; NbExp=3; IntAct=EBI-3958099, EBI-749311;
CC       P10809:HSPD1; NbExp=3; IntAct=EBI-3958099, EBI-352528;
CC       Q15040:JOSD1; NbExp=3; IntAct=EBI-3958099, EBI-2510602;
CC       Q2WGJ6:KLHL38; NbExp=5; IntAct=EBI-3958099, EBI-6426443;
CC       P60412:KRTAP10-11; NbExp=5; IntAct=EBI-3958099, EBI-10217483;
CC       P60370:KRTAP10-5; NbExp=9; IntAct=EBI-3958099, EBI-10172150;
CC       P60409:KRTAP10-7; NbExp=5; IntAct=EBI-3958099, EBI-10172290;
CC       P60410:KRTAP10-8; NbExp=7; IntAct=EBI-3958099, EBI-10171774;
CC       P60411:KRTAP10-9; NbExp=5; IntAct=EBI-3958099, EBI-10172052;
CC       P59990:KRTAP12-1; NbExp=5; IntAct=EBI-3958099, EBI-10210845;
CC       P59991:KRTAP12-2; NbExp=5; IntAct=EBI-3958099, EBI-10176379;
CC       Q9BYQ6:KRTAP4-11; NbExp=5; IntAct=EBI-3958099, EBI-10302392;
CC       Q9BQ66:KRTAP4-12; NbExp=7; IntAct=EBI-3958099, EBI-739863;
CC       Q9BYR5:KRTAP4-2; NbExp=7; IntAct=EBI-3958099, EBI-10172511;
CC       Q6L8H1:KRTAP5-4; NbExp=4; IntAct=EBI-3958099, EBI-11963072;
CC       Q6L8G9:KRTAP5-6; NbExp=7; IntAct=EBI-3958099, EBI-10250562;
CC       Q9BYQ4:KRTAP9-2; NbExp=5; IntAct=EBI-3958099, EBI-1044640;
CC       Q9BYQ3:KRTAP9-3; NbExp=4; IntAct=EBI-3958099, EBI-1043191;
CC       Q9BYQ2:KRTAP9-4; NbExp=3; IntAct=EBI-3958099, EBI-10185730;
CC       Q9BYQ0:KRTAP9-8; NbExp=4; IntAct=EBI-3958099, EBI-11958364;
CC       Q5T7P3:LCE1B; NbExp=5; IntAct=EBI-3958099, EBI-10245913;
CC       Q5T752:LCE1D; NbExp=4; IntAct=EBI-3958099, EBI-11741311;
CC       Q5T753:LCE1E; NbExp=4; IntAct=EBI-3958099, EBI-11955335;
CC       Q5T754:LCE1F; NbExp=4; IntAct=EBI-3958099, EBI-11958008;
CC       Q5TA79:LCE2A; NbExp=7; IntAct=EBI-3958099, EBI-10246607;
CC       O14633:LCE2B; NbExp=4; IntAct=EBI-3958099, EBI-11478468;
CC       Q5TA81:LCE2C; NbExp=4; IntAct=EBI-3958099, EBI-11973993;
CC       Q5TA76:LCE3A; NbExp=4; IntAct=EBI-3958099, EBI-9394625;
CC       Q5TA77:LCE3B; NbExp=4; IntAct=EBI-3958099, EBI-11974495;
CC       Q5T5A8:LCE3C; NbExp=7; IntAct=EBI-3958099, EBI-10245291;
CC       Q5T5B0:LCE3E; NbExp=7; IntAct=EBI-3958099, EBI-10245456;
CC       Q5TA78:LCE4A; NbExp=5; IntAct=EBI-3958099, EBI-10246358;
CC       Q5TCM9:LCE5A; NbExp=4; IntAct=EBI-3958099, EBI-11955689;
CC       O94772:LY6H; NbExp=3; IntAct=EBI-3958099, EBI-724687;
CC       O60336:MAPKBP1; NbExp=5; IntAct=EBI-3958099, EBI-947402;
CC       P50222:MEOX2; NbExp=3; IntAct=EBI-3958099, EBI-748397;
CC       Q549C5:MST065; NbExp=3; IntAct=EBI-3958099, EBI-10243297;
CC       Q8IW45:NAXD; NbExp=3; IntAct=EBI-3958099, EBI-8650724;
CC       Q969V3-2:NCLN; NbExp=3; IntAct=EBI-3958099, EBI-10281480;
CC       Q92692:NECTIN2; NbExp=3; IntAct=EBI-3958099, EBI-718419;
CC       Q9UBE8:NLK; NbExp=3; IntAct=EBI-3958099, EBI-366978;
CC       P48645:NMU; NbExp=5; IntAct=EBI-3958099, EBI-10210351;
CC       Q7Z3S9:NOTCH2NLA; NbExp=5; IntAct=EBI-3958099, EBI-945833;
CC       P48146:NPBWR2; NbExp=3; IntAct=EBI-3958099, EBI-10210114;
CC       Q9NQX5:NPDC1; NbExp=5; IntAct=EBI-3958099, EBI-748927;
CC       Q9P121:NTM; NbExp=3; IntAct=EBI-3958099, EBI-4315078;
CC       Q9HB63:NTN4; NbExp=3; IntAct=EBI-3958099, EBI-743459;
CC       Q9HB63-3:NTN4; NbExp=3; IntAct=EBI-3958099, EBI-10310092;
CC       Q7Z417:NUFIP2; NbExp=5; IntAct=EBI-3958099, EBI-1210753;
CC       P32242:OTX1; NbExp=9; IntAct=EBI-3958099, EBI-740446;
CC       Q99571:P2RX4; NbExp=3; IntAct=EBI-3958099, EBI-2828248;
CC       Q92824:PCSK5; NbExp=3; IntAct=EBI-3958099, EBI-751290;
CC       P17858:PFKL; NbExp=3; IntAct=EBI-3958099, EBI-487243;
CC       O43741:PRKAB2; NbExp=5; IntAct=EBI-3958099, EBI-1053424;
CC       P25786:PSMA1; NbExp=5; IntAct=EBI-3958099, EBI-359352;
CC       Q8WUK0:PTPMT1; NbExp=5; IntAct=EBI-3958099, EBI-7199479;
CC       O60896:RAMP3; NbExp=3; IntAct=EBI-3958099, EBI-720447;
CC       O76081:RGS20; NbExp=3; IntAct=EBI-3958099, EBI-1052678;
CC       O76081-6:RGS20; NbExp=5; IntAct=EBI-3958099, EBI-10178530;
CC       Q6ZNA4:RNF111; NbExp=4; IntAct=EBI-3958099, EBI-2129175;
CC       Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-3958099, EBI-10313866;
CC       Q8WTV0:SCARB1; NbExp=3; IntAct=EBI-3958099, EBI-78657;
CC       A0A0S2Z4U3:SDC3; NbExp=9; IntAct=EBI-3958099, EBI-10204280;
CC       O00560:SDCBP; NbExp=5; IntAct=EBI-3958099, EBI-727004;
CC       A1A5C7:SLC22A23; NbExp=3; IntAct=EBI-3958099, EBI-10171756;
CC       Q9UBX3:SLC25A10; NbExp=3; IntAct=EBI-3958099, EBI-750394;
CC       Q9UBX3-2:SLC25A10; NbExp=3; IntAct=EBI-3958099, EBI-12056597;
CC       P49901:SMCP; NbExp=9; IntAct=EBI-3958099, EBI-750494;
CC       P20155:SPINK2; NbExp=3; IntAct=EBI-3958099, EBI-10200479;
CC       O43597:SPRY2; NbExp=3; IntAct=EBI-3958099, EBI-742487;
CC       Q8IV04:TBC1D10C; NbExp=3; IntAct=EBI-3958099, EBI-10261452;
CC       Q15560:TCEA2; NbExp=3; IntAct=EBI-3958099, EBI-710310;
CC       Q8N8B7:TCEANC; NbExp=3; IntAct=EBI-3958099, EBI-954696;
CC       Q06418:TYRO3; NbExp=4; IntAct=EBI-3958099, EBI-3951628;
CC       Q96HA8:WDYHV1; NbExp=5; IntAct=EBI-3958099, EBI-741158;
CC       Q9GZM5:YIPF3; NbExp=3; IntAct=EBI-3958099, EBI-743787;
CC       O43167:ZBTB24; NbExp=3; IntAct=EBI-3958099, EBI-744471;
CC       Q9BQ24:ZFYVE21; NbExp=3; IntAct=EBI-3958099, EBI-2849569;
CC       Q15973:ZNF124; NbExp=5; IntAct=EBI-3958099, EBI-2555767;
CC       Q14584:ZNF266; NbExp=3; IntAct=EBI-3958099, EBI-7115319;
CC       Q8TAU3:ZNF417; NbExp=5; IntAct=EBI-3958099, EBI-740727;
CC       Q8NDP4:ZNF439; NbExp=5; IntAct=EBI-3958099, EBI-747580;
CC       Q9P0T4:ZNF581; NbExp=3; IntAct=EBI-3958099, EBI-745520;
CC       Q96SQ5:ZNF587; NbExp=5; IntAct=EBI-3958099, EBI-6427977;
CC   -!- TISSUE SPECIFICITY: Restricted to hair root, not detected in any
CC       other tissues. Expressed in cuticle layers of differentiating hair
CC       follicles. {ECO:0000269|PubMed:15144888}.
CC   -!- DEVELOPMENTAL STAGE: At a late stage of fiber differentiation.
CC   -!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}.
DR   EMBL; X55293; CAA39005.1; -; Genomic_DNA.
DR   EMBL; AJ006693; CAA07189.1; -; Genomic_DNA.
DR   EMBL; X63755; CAA45283.1; -; mRNA.
DR   EMBL; AB126078; BAD20205.1; -; mRNA.
DR   EMBL; BC069531; AAH69531.1; -; mRNA.
DR   EMBL; BC101744; AAI01745.2; -; mRNA.
DR   CCDS; CCDS53677.1; -.
DR   PIR; S18946; S18946.
DR   RefSeq; NP_005544.4; NM_005553.3.
DR   BioGrid; 110044; 109.
DR   IntAct; P26371; 191.
DR   MINT; P26371; -.
DR   STRING; 9606.ENSP00000431443; -.
DR   iPTMnet; P26371; -.
DR   PhosphoSitePlus; P26371; -.
DR   BioMuta; KRTAP5-9; -.
DR   PaxDb; P26371; -.
DR   PRIDE; P26371; -.
DR   ProteomicsDB; 54327; -.
DR   DNASU; 3846; -.
DR   Ensembl; ENST00000528743; ENSP00000431443; ENSG00000254997.
DR   GeneID; 3846; -.
DR   KEGG; hsa:3846; -.
DR   UCSC; uc001oqs.2; human.
DR   CTD; 3846; -.
DR   DisGeNET; 3846; -.
DR   GeneCards; KRTAP5-9; -.
DR   HGNC; HGNC:23604; KRTAP5-9.
DR   MIM; 148021; gene.
DR   neXtProt; NX_P26371; -.
DR   OpenTargets; ENSG00000254997; -.
DR   PharmGKB; PA134946701; -.
DR   GeneTree; ENSGT00950000186550; -.
DR   OMA; QYSGFTR; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   GenomeRNAi; 3846; -.
DR   Pharos; P26371; -.
DR   PRO; PR:P26371; -.
DR   Proteomes; UP000005640; Unplaced.
DR   Bgee; ENSG00000254997; Expressed in 67 organ(s), highest expression level in hair follicle.
DR   Genevisible; P26371; HS.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0008544; P:epidermis development; TAS:ProtInc.
DR   GO; GO:0031424; P:keratinization; TAS:Reactome.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Keratin; Polymorphism; Reference proteome; Repeat.
FT   CHAIN         1    169       Keratin-associated protein 5-9.
FT                                /FTId=PRO_0000184107.
FT   REPEAT       35     38       1.
FT   REPEAT       41     44       2.
FT   REPEAT       47     50       3.
FT   REPEAT       82     85       4.
FT   REPEAT      101    104       5.
FT   REPEAT      130    134       6.
FT   REPEAT      149    152       7.
FT   REPEAT      159    162       8.
FT   REGION       35    162       8 X 4 AA repeats of C-C-X-P.
FT   VARIANT       8      8       G -> R (in dbSNP:rs34213141).
FT                                /FTId=VAR_053731.
FT   VARIANT      40     40       Y -> C (in dbSNP:rs10792769).
FT                                {ECO:0000269|Ref.3}.
FT                                /FTId=VAR_053732.
SQ   SEQUENCE   169 AA;  16276 MW;  219B14FEEB49D4AB CRC64;
     MGCCGCSGGC GSSCGGCDSS CGSCGSGCRG CGPSCCAPVY CCKPVCCCVP ACSCSSCGKR
     GCGSCGGSKG GCGSCGCSQC SCCKPCCCSS GCGSSCCQCS CCKPYCSQCS CCKPCCSSSG
     RGSSCCQSSC CKPCCSSSGC GSSCCQSSCC KPCCSQSRCC VPVCYQCKI
//
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