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Database: UniProt
Entry: P26474
LinkDB: P26474
Original site: P26474 
ID   ASRA_SALTY              Reviewed;         347 AA.
AC   P26474;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   10-APR-2019, entry version 118.
DE   RecName: Full=Anaerobic sulfite reductase subunit A;
DE   AltName: Full=Anaerobic sulfite reductase iron-sulfur subunit;
GN   Name=asrA; OrderedLocusNames=STM2548;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=EB303;
RX   PubMed=1704886; DOI=10.1128/jb.173.4.1544-1553.1991;
RA   Huang C.J., Barrett E.L.;
RT   "Sequence analysis and expression of the Salmonella typhimurium asr
RT   operon encoding production of hydrogen sulfide from sulfite.";
RL   J. Bacteriol. 173:1544-1553(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA   Waterston R., Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT   LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Electron transfer protein for anaerobic sulfite
CC       reductase subunit A.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 2 [4Fe-4S] clusters.;
CC   -!- PATHWAY: Sulfur metabolism; sulfite reduction.
CC   -!- SUBUNIT: The anaerobic sulfite reductase seems to consist of three
CC       subunits.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- INDUCTION: By sulfite. Repressed by oxygen.
DR   EMBL; M57706; AAA99275.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL21442.1; -; Genomic_DNA.
DR   PIR; A38453; A38453.
DR   RefSeq; NP_461483.1; NC_003197.2.
DR   RefSeq; WP_000985204.1; NC_003197.2.
DR   ProteinModelPortal; P26474; -.
DR   PaxDb; P26474; -.
DR   EnsemblBacteria; AAL21442; AAL21442; STM2548.
DR   GeneID; 1254070; -.
DR   KEGG; stm:STM2548; -.
DR   PATRIC; fig|99287.12.peg.2688; -.
DR   eggNOG; ENOG4105D5B; Bacteria.
DR   eggNOG; COG1145; LUCA.
DR   HOGENOM; HOG000279066; -.
DR   KO; K16950; -.
DR   OMA; VCPEYIS; -.
DR   BioCyc; MetaCyc:MONOMER-12544; -.
DR   BioCyc; SENT99287:STM2548-MONOMER; -.
DR   UniPathway; UPA00370; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation-reduction process; IEA:UniProtKB-KW.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   InterPro; IPR014259; Sulphite_reductase_A.
DR   Pfam; PF17179; Fer4_22; 1.
DR   SUPFAM; SSF46548; SSF46548; 1.
DR   TIGRFAMs; TIGR02910; sulfite_red_A; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 2.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   2: Evidence at transcript level;
KW   4Fe-4S; Complete proteome; Cytoplasm; Electron transport; Iron;
KW   Iron-sulfur; Metal-binding; Reference proteome; Repeat; Transport.
FT   CHAIN         1    347       Anaerobic sulfite reductase subunit A.
FT                                /FTId=PRO_0000159257.
FT   DOMAIN      219    251       4Fe-4S ferredoxin-type 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   DOMAIN      302    331       4Fe-4S ferredoxin-type 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL       230    230       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL       233    233       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL       236    236       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL       240    240       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL       312    312       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       315    315       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       318    318       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       322    322       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
SQ   SEQUENCE   347 AA;  39680 MW;  45B2C5DAEBF14296 CRC64;
     MAIKITPDEF SLLIQRLNKK WRVFAPSAEF RGGRFSDTDN IIYQRISGWR DLIWHEKSHM
     SPNTIIAPIT ETLFYFDKDT IQIAETDTSP IIIFARACDI NAMSRLDYMY LSNGNNSDYS
     YQLLREHIRF VLIECEESFE NCFCVSMGTN KTDCYSAAMR FSDEGALVSI RDPFIEAAIQ
     GLGQEADYTP SFVSENRETV VTPDSVCHDP QKIRDILTHH PLWDAYDSRC ISCGRCTTGC
     PTCTCYSVFD VAYDENPQRG ERRRQWASCM VPGFSDMAGG HGFREKPGER LRYRALHKVN
     DYKARNGIEH MCVGCGRCDD RCPQYIKFSL IINKMTAAVR QALAEEA
//
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