ID FOSX_MSVFR Reviewed; 244 AA.
AC P29176;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE RecName: Full=Transforming protein v-Fos/v-Fox;
GN Name=FOS-FOX;
OS FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine
OS osteosarcoma virus).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Gammaretrovirus.
OX NCBI_TaxID=353765;
OH NCBI_TaxID=10090; Mus musculus (Mouse).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6203215; DOI=10.1016/0042-6822(84)90133-8;
RA van Beveren C., Enami S., Curran T., Verma I.M.;
RT "FBR murine osteosarcoma virus. II. Nucleotide sequence of the provirus
RT reveals that the genome contains sequences acquired from two cellular
RT genes.";
RL Virology 135:229-243(1984).
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC -!- MISCELLANEOUS: This protein is synthesized as a Gag-Fos-Fox
CC polyprotein.
CC -!- SIMILARITY: Belongs to the bZIP family. Fos subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA46573.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; K02712; AAA46573.1; ALT_INIT; Genomic_DNA.
DR PIR; B23244; TVMVFB.
DR SMR; P29176; -.
DR Proteomes; UP000237129; Segment.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14721; bZIP_Fos; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR000837; AP-1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR23351; FOS TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR23351:SF4; PROTEIN C-FOS; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR PRINTS; PR00042; LEUZIPPRFOS.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW DNA-binding; Host nucleus; Oncogene.
FT CHAIN 1..244
FT /note="Transforming protein v-Fos/v-Fox"
FT /id="PRO_0000076461"
FT DOMAIN 113..176
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..236
FT /note="Transforming protein v-Fos"
FT REGION 115..135
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 141..169
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 237..244
FT /note="Transforming protein v-Fox"
SQ SEQUENCE 244 AA; 26622 MW; 95C904B66B0EB270 CRC64;
DSLSYYHSPA DSFSSMGSPV NTQDFCADLS VSSANFIPTE TAISTSPDLQ WLVQPTLVSS
VAPSQTRAPH PYGLPTQSAG AYARAGMVKT VSGGRAQSIG RRGKVEQLSP EEEVKRRIRR
ERNKMAAAKC RNRRRELTDT LQAETDQLED EKSALQTEIA NLLKEKEKLE FILAAHRPAC
KIPDDLGFPE EMSVASLDLT GGLLPLLNDP EPKPSLEPVK SSFDDFLFPA SSGHSGFISM
AGWQ
//
