GenomeNet

Database: UniProt
Entry: P29775
LinkDB: P29775
Original site: P29775 
ID   ETS4_DROME              Reviewed;         518 AA.
AC   P29775; Q9VB00;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 3.
DT   07-OCT-2020, entry version 166.
DE   RecName: Full=DNA-binding protein D-ETS-4;
GN   Name=Ets98B; Synonyms=ETS-4; ORFNames=CG5583;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 405-518, FUNCTION, TISSUE SPECIFICITY,
RP   AND DEVELOPMENTAL STAGE.
RC   STRAIN=Canton-S; TISSUE=Larva;
RX   PubMed=1577186; DOI=10.1016/0012-1606(92)90225-6;
RA   Chen T., Bunting M., Karim F.D., Thummel C.S.;
RT   "Isolation and characterization of five Drosophila genes that encode an
RT   ets-related DNA binding domain.";
RL   Dev. Biol. 151:176-191(1992).
CC   -!- FUNCTION: May have a role in germline development.
CC       {ECO:0000269|PubMed:1577186}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Transient high expression in pole cells during
CC       embryonic stages 8-11. {ECO:0000269|PubMed:1577186}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout development with lower levels
CC       during larval development. {ECO:0000269|PubMed:1577186}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
DR   EMBL; AE014297; AAF56746.2; -; Genomic_DNA.
DR   EMBL; M88474; AAA28451.1; -; Genomic_DNA.
DR   PIR; S28821; S28821.
DR   RefSeq; NP_524535.2; NM_079811.4.
DR   SMR; P29775; -.
DR   BioGRID; 68216; 2.
DR   DIP; DIP-23688N; -.
DR   STRING; 7227.FBpp0084594; -.
DR   PaxDb; P29775; -.
DR   EnsemblMetazoa; FBtr0085224; FBpp0084594; FBgn0005659.
DR   GeneID; 43334; -.
DR   KEGG; dme:Dmel_CG5583; -.
DR   CTD; 43334; -.
DR   FlyBase; FBgn0005659; Ets98B.
DR   eggNOG; KOG3805; Eukaryota.
DR   GeneTree; ENSGT00940000157549; -.
DR   InParanoid; P29775; -.
DR   KO; K09442; -.
DR   OMA; YEKMLYM; -.
DR   OrthoDB; 908495at2759; -.
DR   PhylomeDB; P29775; -.
DR   BioGRID-ORCS; 43334; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 43334; -.
DR   PRO; PR:P29775; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0005659; Expressed in multi-cellular organism and 28 other tissues.
DR   ExpressionAtlas; P29775; baseline and differential.
DR   Genevisible; P29775; DM.
DR   GO; GO:0042025; C:host cell nucleus; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..518
FT                   /note="DNA-binding protein D-ETS-4"
FT                   /id="PRO_0000204108"
FT   DOMAIN          258..344
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        430..513
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
SQ   SEQUENCE   518 AA;  57713 MW;  B4B59F5EBB07454C CRC64;
     MEYEKMLYMP AASEMPHSPQ LKPHQFQAHT PTDQYSSYAD NFDLSLLPQE SASIPTTVFQ
     YNAPQIKVEC AWDSQPIQQQ QQPTAPYTNP SSHQLIPPPA YPHSAYPSPQ SSPLQSEFAA
     YGLGRFGGSY DSLNSPSPSL EAVSIKQELH ILPPSPPESN CETPSPRSSC GESIKAEPLD
     ADIESLIDLN SLLQQQSLQS PQNLQDTKPD HQLLRECLED TSFQKRHNLK PLALESFIGG
     LAEVRGDFEP VISLALEHAK READAICAEL QISQDPNGWS PAQVHAWLRS TLAQFRLPPV
     ADLELHFCEN GAALALLSEE EFVRRLPESG STLHAQLEIW KMAYADQPAH QQHSQQSAST
     DHWPASYAMP HLDLDYNEDS EDDDDMEADA QVAPLNGSTT SPPATNASNG GTATVKRPNG
     GRTGGGGSHI HLWQFLKELL ASPQVNGTAI RWIDRSKGIF KIEDSVRVAK LWGRRKNRPA
     MNYDKLSRSI RQYYKKGIMK KTERSQRLVY QFCHPYSQ
//
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