ID HXA2_MOUSE Reviewed; 372 AA.
AC P31245; Q149U3; Q920T8;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 24-JAN-2024, entry version 171.
DE RecName: Full=Homeobox protein Hox-A2;
DE AltName: Full=Homeobox protein Hox-1.11;
DE Short=Hox1.11;
GN Name=Hoxa2; Synonyms=Hox-1.11, Hoxa-2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Gridley T.;
RT "Cloning of mouse Hox 1-11.";
RL Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=ICR X Swiss Webster;
RX PubMed=1352886; DOI=10.1073/pnas.89.14.6280;
RA Tan D.P., Ferrante J., Nazarali A., Shao X., Kozak C.A., Guo V.,
RA Nirenberg M.;
RT "Murine Hox-1.11 homeobox gene structure and expression.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:6280-6284(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-231.
RC STRAIN=ICR X Swiss Webster;
RX PubMed=1348361; DOI=10.1073/pnas.89.7.2883;
RA Nazarali A., Kim Y., Nirenberg M.;
RT "Hox-1.11 and Hox-4.9 homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:2883-2887(1992).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-372.
RC STRAIN=HMI/Msf;
RA Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.;
RT "Conspicuous differences among gene genealogies of 21 nuclear genes of five
RT Mus musculus subspecies.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC subfamily. {ECO:0000305}.
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DR EMBL; M95599; AAA37827.1; -; mRNA.
DR EMBL; M93148; AAA37835.1; -; Genomic_DNA.
DR EMBL; M93292; AAA37836.1; -; mRNA.
DR EMBL; BC117105; AAI17106.1; -; mRNA.
DR EMBL; BC117107; AAI17108.1; -; mRNA.
DR EMBL; M87801; AAA37834.1; -; Genomic_DNA.
DR EMBL; AB039191; BAB68715.1; -; Genomic_DNA.
DR CCDS; CCDS20139.1; -.
DR PIR; A42694; A42694.
DR PIR; A46037; A46037.
DR RefSeq; NP_034581.1; NM_010451.2.
DR AlphaFoldDB; P31245; -.
DR SMR; P31245; -.
DR BioGRID; 200367; 24.
DR IntAct; P31245; 14.
DR STRING; 10090.ENSMUSP00000014848; -.
DR PhosphoSitePlus; P31245; -.
DR PaxDb; 10090-ENSMUSP00000014848; -.
DR Antibodypedia; 12364; 203 antibodies from 27 providers.
DR DNASU; 15399; -.
DR Ensembl; ENSMUST00000014848.11; ENSMUSP00000014848.9; ENSMUSG00000014704.11.
DR GeneID; 15399; -.
DR KEGG; mmu:15399; -.
DR UCSC; uc009bxz.2; mouse.
DR AGR; MGI:96174; -.
DR CTD; 3199; -.
DR MGI; MGI:96174; Hoxa2.
DR VEuPathDB; HostDB:ENSMUSG00000014704; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000162533; -.
DR HOGENOM; CLU_048378_0_0_1; -.
DR InParanoid; P31245; -.
DR OMA; VHNGESQ; -.
DR OrthoDB; 728401at2759; -.
DR PhylomeDB; P31245; -.
DR TreeFam; TF317730; -.
DR BioGRID-ORCS; 15399; 1 hit in 76 CRISPR screens.
DR PRO; PR:P31245; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P31245; Protein.
DR Bgee; ENSMUSG00000014704; Expressed in pharyngeal arch 2 and 119 other cell types or tissues.
DR Genevisible; P31245; MM.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0035284; P:brain segmentation; IMP:MGI.
DR GO; GO:0045165; P:cell fate commitment; IMP:MGI.
DR GO; GO:0001709; P:cell fate determination; IMP:MGI.
DR GO; GO:0071300; P:cellular response to retinoic acid; IDA:MGI.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IDA:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:MGI.
DR GO; GO:0042474; P:middle ear morphogenesis; IMP:MGI.
DR GO; GO:0008045; P:motor neuron axon guidance; IMP:MGI.
DR GO; GO:0061061; P:muscle structure development; IDA:MGI.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IMP:MGI.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IDA:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0002076; P:osteoblast development; IGI:MGI.
DR GO; GO:0007389; P:pattern specification process; IMP:MGI.
DR GO; GO:0060037; P:pharyngeal system development; IDA:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0021568; P:rhombomere 2 development; IMP:MGI.
DR GO; GO:0021569; P:rhombomere 3 development; IGI:MGI.
DR GO; GO:0021658; P:rhombomere 3 morphogenesis; IMP:MGI.
DR GO; GO:0007379; P:segment specification; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45664:SF3; HOMEOBOX PROTEIN HOX-A2; 1.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..372
FT /note="Homeobox protein Hox-A2"
FT /id="PRO_0000200037"
FT DNA_BIND 139..198
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 48..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 96..101
FT /note="Antp-type hexapeptide"
FT COMPBIAS 198..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 40793 MW; 0ADA79113DB72726 CRC64;
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN
PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM KEKKAAKKTA LPPAAASTGP
ACLGHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE
RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL
EREGYTFQQN ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN
CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI SADSFDFFTD
TLTTIDLQHL NY
//
