ID HEMR_YEREN Reviewed; 687 AA.
AC P31499;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 27-MAR-2024, entry version 103.
DE RecName: Full=Hemin receptor;
DE Flags: Precursor;
GN Name=hemR;
OS Yersinia enterocolitica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=630;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 51872 / WA-C / Serotype O:8;
RX PubMed=1425573; DOI=10.1002/j.1460-2075.1992.tb05535.x;
RA Stojiljkovic I., Hantke K.;
RT "Hemin uptake system of Yersinia enterocolitica: similarities with other
RT TonB-dependent systems in Gram-negative bacteria.";
RL EMBO J. 11:4359-4367(1992).
RN [2]
RP SEQUENCE REVISION.
RA Stojiljkovic I.;
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP EXPRESSION.
RC STRAIN=ATCC 51872 / WA-C / Serotype O:8;
RX PubMed=11705959; DOI=10.1128/iai.69.12.7772-7782.2001;
RA Jacobi C.A., Gregor S., Rakin A., Heesemann J.;
RT "Expression analysis of the yersiniabactin receptor gene fyuA and the heme
RT receptor hemR of Yersinia enterocolitica in vitro and in vivo using the
RT reporter genes for green fluorescent protein and luciferase.";
RL Infect. Immun. 69:7772-7782(2001).
CC -!- FUNCTION: This protein is involved in the initial step of iron uptake
CC by binding hemin, an iron chelatin siderophore that allows the bacteria
CC to extract iron from the environment.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|PROSITE-
CC ProRule:PRU01360}; Multi-pass membrane protein {ECO:0000255|PROSITE-
CC ProRule:PRU01360}.
CC -!- INDUCTION: Induced in absence of iron.
CC -!- MISCELLANEOUS: Weakly expressed by yersiniae located in the liver and
CC the intestinal lumen. Strongly expressed in yersiniae located in the
CC peritoneal cavity. Moderately expressed in yersiniae located in the
CC spleen. This probably reflects the availability of iron for yersiniae.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000305}.
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DR EMBL; X68147; CAA48250.1; -; Genomic_DNA.
DR PIR; S28042; S28042.
DR AlphaFoldDB; P31499; -.
DR SMR; P31499; -.
DR STRING; 1443113.LC20_04857; -.
DR TCDB; 1.B.14.2.2; the outer membrane receptor (omr) family.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR CDD; cd01347; ligand_gated_channel; 1.
DR Gene3D; 2.40.170.20; TonB-dependent receptor, beta-barrel domain; 1.
DR Gene3D; 2.170.130.10; TonB-dependent receptor, plug domain; 1.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR039426; TonB-dep_rcpt-like.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR010916; TonB_box_CS.
DR InterPro; IPR011276; TonB_haem/Hb_rcpt.
DR InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR NCBIfam; TIGR01785; TonB-hemin; 1.
DR NCBIfam; TIGR01786; TonB-hemlactrns; 1.
DR PANTHER; PTHR30069:SF58; HEMOGLOBIN AND HEMOGLOBIN-HAPTOGLOBIN-BINDING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR30069; TONB-DEPENDENT OUTER MEMBRANE RECEPTOR; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR SUPFAM; SSF56935; Porins; 1.
DR PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
DR PROSITE; PS52016; TONB_DEPENDENT_REC_3; 1.
PE 2: Evidence at transcript level;
KW Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW Receptor; Signal; TonB box; Transmembrane; Transmembrane beta strand;
KW Transport.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..687
FT /note="Hemin receptor"
FT /id="PRO_0000034758"
FT DOMAIN 56..167
FT /note="TBDR plug"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01360"
FT DOMAIN 178..687
FT /note="TBDR beta-barrel"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01360"
FT REGION 319..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 44..51
FT /note="TonB box"
FT MOTIF 670..687
FT /note="TonB C-terminal box"
SQ SEQUENCE 687 AA; 75226 MW; 69092EF97F5DC08A CRC64;
MPRSTSDRFR WSPLSLAIAC TLSLAVQAAD TSSTQTNSKK RIADTMVVTA TGNERSSFEA
PMMVTVVEAD TPTSETATSA TDMLRNIPGL TVTGSGRVNG QDVTLRGYGK QGVLTLVDGI
RQGTDTGHLN STFLDPALVK RVEIVRGPSA LLYGSGALGG VISYETVDAA DLLLPGQNSG
YRVYSAAATG DHSFGLGASA FGRTDDVDGI LSFGTRDIGN IRQSDGFNAP NDETISNVLA
KGTWRIDQIQ SLSANLRYYN NSALEPKNPQ TSAASSTNLM TDRSTIQRDA QLKYNIKPLD
QEWLNATAQV YYSEVEINAR PQGTPEEGRK QTTKGGKLEN RTRLFTDSFA SHLLTYGTEA
YKQEQTPSGA TESFPQADIR FGSGWLQDEI TLRDLPVSIL AGTRYDNYRG SSEGYADVDA
DKWSSRGAVS VTPTDWLMLF GSYAQAFRAP TMGEMYNDSK HFSMNIMGNT LTNYWVPNPN
LKPETNETQE YGFGLRFNDL MMAEDDLQFK ASYFDTNAKD YISTGVTMDF GFGPGGLYCK
NCSTYSTNID RAKIWGWDAT MTYQTQWFNL GLAYNRTRGK NQNTNEWLDT INPDTVTSTL
DVPVANSGFA VGWIGTFADR SSRVSSSGTP QAGYGVNDFY VSYKGQEQFK GMTTTVVLGN
AFDKGYYGPQ GVPQDGRNAK FFVSYQW
//
