ID   BAIG_CLOSV              Reviewed;         477 AA.
AC   P32369; Q47873;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=Bile acid transporter;
GN   Name=baiG;
OS   Clostridium scindens (strain JCM 10418 / VPI 12708).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=29347;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Mallonee D.H., Hylemon P.B.;
RL   Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-477.
RX   PubMed=8491719; DOI=10.1128/jb.175.10.3002-3012.1993;
RA   Franklund C.V., Baron S.F., Hylemon P.B.;
RT   "Characterization of the baiH gene encoding a bile acid-inducible
RT   NADH:flavin oxidoreductase from Eubacterium sp. strain VPI 12708.";
RL   J. Bacteriol. 175:3002-3012(1993).
CC   -!- PATHWAY: Lipid metabolism; bile acid degradation.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U57489; AAC45416.1; -; Genomic_DNA.
DR   PIR; A36912; A36912.
DR   RefSeq; WP_025645816.1; NZ_JANGEG010000007.1.
DR   AlphaFoldDB; P32369; -.
DR   SMR; P32369; -.
DR   TCDB; 2.A.1.3.13; the major facilitator superfamily (mfs).
DR   UniPathway; UPA00279; -.
DR   GO; GO:0016020; C:membrane; IC:UniProt.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015125; F:bile acid transmembrane transporter activity; IDA:UniProt.
DR   GO; GO:0015721; P:bile acid and bile salt transport; IDA:UniProt.
DR   GO; GO:0030573; P:bile acid catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd17321; MFS_MMR_MDR_like; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR42718; MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC; 1.
DR   PANTHER; PTHR42718:SF9; METHYL VIOLOGEN RESISTANCE PROTEIN SMVA; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Bile acid catabolism; Cell membrane; Lipid degradation; Lipid metabolism;
KW   Membrane; Steroid metabolism; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..477
FT                   /note="Bile acid transporter"
FT                   /id="PRO_0000173314"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        444..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        442
FT                   /note="A -> T (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   477 AA;  49938 MW;  523A906B3187BDF9 CRC64;
     MSTVANPNYK KGFVPFAIAA LLVSLIGGFT AVLGPAFVAD QGIDYNNTTW ISLALAMSSA
     ACAPILGKLG DVLGRRTTLL LGIVIFAAGN VLTAVATSLI FMLAARFIVG IGTAAISPIV
     MAYIVTEYPQ EETGKAFGLY MLISSGAVVV GPTCGGLIMN AAGWRVMMWV CVALCVVVFL
     ICTFSIKKTA FEKKSMAGFD KPGAALVVVF FSLFLCIPSF GQNIGWSSTA FIAAAAVALV
     ALFILVMVEK KAKSPIMNGK FMARKEFVLP VLILFLTQGL MMANMTNVIV FVRYTQPDNV
     IISSFAISIM YIGMSLGSVI IGPVADKKEP KTVLTFSLVL TAIGCALMYL FKADSSVAIF
     AASLGILGFG LGGNATIFMK VALSGLSSEV AGSGTGTYGL FRDISAPFGV AVFVPMFANG
     VTANIAKYAS GGMEEGAATV KAAISSIQTL TLVELGCIVV GIILVRMLPR IYQKKEA
//