ID DCA13_YEAST Reviewed; 489 AA.
AC P33750; D6VXZ1;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 27-MAR-2024, entry version 188.
DE RecName: Full=Protein SOF1;
DE AltName: Full=U3 small nucleolar RNA-associated protein SOF1;
DE Short=U3 snoRNA-associated protein SOF1;
GN Name=SOF1; OrderedLocusNames=YLL011W; ORFNames=L1339;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH NOP1 AND
RP SNORNA U3, AND SUBCELLULAR LOCATION.
RX PubMed=8508778; DOI=10.1002/j.1460-2075.1993.tb05910.x;
RA Jansen R., Tollervey D., Hurt E.C.;
RT "A U3 snoRNP protein with homology to splicing factor PRP4 and G beta
RT domains is required for ribosomal RNA processing.";
RL EMBO J. 12:2549-2558(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 90840 / EAY235 / FY23;
RX PubMed=8810043;
RX DOI=10.1002/(sici)1097-0061(19960615)12:7<693::aid-yea956>3.0.co;2-g;
RA Miosga T., Zimmermann F.K.;
RT "Sequence analysis of the CEN12 region of Saccharomyces cerevisiae on a
RT 43.7 kb fragment of chromosome XII including an open reading frame
RT homologous to the human cystic fibrosis transmembrane conductance regulator
RT protein CFTR.";
RL Yeast 12:693-708(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP INTERACTION WITH MPP10 AND SNORNA U3, AND IDENTIFICATION IN SSU PROCESSOME
RP BY MASS SPECTROMETRY.
RX PubMed=12068309; DOI=10.1038/nature00769;
RA Dragon F., Gallagher J.E.G., Compagnone-Post P.A., Mitchell B.M.,
RA Porwancher K.A., Wehner K.A., Wormsley S., Settlage R.E., Shabanowitz J.,
RA Osheim Y., Beyer A.L., Hunt D.F., Baserga S.J.;
RT "A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA
RT biogenesis.";
RL Nature 417:967-970(2002).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Required for ribosomal RNA processing.
CC {ECO:0000269|PubMed:8508778}.
CC -!- SUBUNIT: Interacts with snoRNA U3. Interacts with NOP1 and MPP10.
CC Component of the ribosomal small subunit (SSU) processome composed of
CC at least 40 protein subunits and snoRNA U3.
CC {ECO:0000269|PubMed:12068309, ECO:0000269|PubMed:8508778}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:8508778}.
CC -!- MISCELLANEOUS: Present with 6620 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family.
CC {ECO:0000305}.
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DR EMBL; X70052; CAA49658.1; -; Genomic_DNA.
DR EMBL; X91488; CAA62781.1; -; Genomic_DNA.
DR EMBL; Z73116; CAA97455.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09307.1; -; Genomic_DNA.
DR PIR; S35323; S35323.
DR RefSeq; NP_013090.1; NM_001181831.1.
DR PDB; 5WLC; EM; 3.80 A; LU=1-489.
DR PDB; 6KE6; EM; 3.40 A; 5I=1-489.
DR PDB; 6LQP; EM; 3.20 A; 5I=1-489.
DR PDB; 6LQQ; EM; 4.10 A; 5I=1-489.
DR PDB; 6LQR; EM; 8.60 A; 5I=1-489.
DR PDB; 6LQS; EM; 3.80 A; 5I=1-489.
DR PDB; 6LQT; EM; 4.90 A; 5I=1-489.
DR PDB; 6LQU; EM; 3.70 A; 5I=1-489.
DR PDB; 6LQV; EM; 4.80 A; 5I=1-489.
DR PDB; 6ND4; EM; 4.30 A; U=1-489.
DR PDB; 6ZQA; EM; 4.40 A; JP=1-489.
DR PDB; 6ZQB; EM; 3.90 A; JP=1-489.
DR PDB; 6ZQC; EM; 3.80 A; JP=1-489.
DR PDB; 6ZQD; EM; 3.80 A; JP=1-489.
DR PDB; 7AJT; EM; 4.60 A; JP=1-489.
DR PDB; 7AJU; EM; 3.80 A; JP=1-489.
DR PDB; 7D4I; EM; 4.00 A; 5I=1-489.
DR PDB; 7D5S; EM; 4.60 A; 5I=1-489.
DR PDB; 7D5T; EM; 6.00 A; 5I=1-489.
DR PDB; 7D63; EM; 12.30 A; 5I=1-489.
DR PDB; 7SUK; EM; 3.99 A; LU=1-465.
DR PDBsum; 5WLC; -.
DR PDBsum; 6KE6; -.
DR PDBsum; 6LQP; -.
DR PDBsum; 6LQQ; -.
DR PDBsum; 6LQR; -.
DR PDBsum; 6LQS; -.
DR PDBsum; 6LQT; -.
DR PDBsum; 6LQU; -.
DR PDBsum; 6LQV; -.
DR PDBsum; 6ND4; -.
DR PDBsum; 6ZQA; -.
DR PDBsum; 6ZQB; -.
DR PDBsum; 6ZQC; -.
DR PDBsum; 6ZQD; -.
DR PDBsum; 7AJT; -.
DR PDBsum; 7AJU; -.
DR PDBsum; 7D4I; -.
DR PDBsum; 7D5S; -.
DR PDBsum; 7D5T; -.
DR PDBsum; 7D63; -.
DR PDBsum; 7SUK; -.
DR AlphaFoldDB; P33750; -.
DR EMDB; EMD-0441; -.
DR EMDB; EMD-0949; -.
DR EMDB; EMD-0950; -.
DR EMDB; EMD-0951; -.
DR EMDB; EMD-0952; -.
DR EMDB; EMD-0953; -.
DR EMDB; EMD-0954; -.
DR EMDB; EMD-0955; -.
DR EMDB; EMD-11357; -.
DR EMDB; EMD-11358; -.
DR EMDB; EMD-11359; -.
DR EMDB; EMD-11360; -.
DR EMDB; EMD-11807; -.
DR EMDB; EMD-11808; -.
DR EMDB; EMD-25441; -.
DR EMDB; EMD-30574; -.
DR EMDB; EMD-30584; -.
DR EMDB; EMD-30585; -.
DR EMDB; EMD-30588; -.
DR EMDB; EMD-8859; -.
DR EMDB; EMD-9964; -.
DR SMR; P33750; -.
DR BioGRID; 31240; 260.
DR ComplexPortal; CPX-1604; Small ribosomal subunit processome.
DR DIP; DIP-746N; -.
DR IntAct; P33750; 37.
DR MINT; P33750; -.
DR STRING; 4932.YLL011W; -.
DR GlyGen; P33750; 3 sites, 1 O-linked glycan (3 sites).
DR iPTMnet; P33750; -.
DR MaxQB; P33750; -.
DR PaxDb; 4932-YLL011W; -.
DR PeptideAtlas; P33750; -.
DR EnsemblFungi; YLL011W_mRNA; YLL011W; YLL011W.
DR GeneID; 850649; -.
DR KEGG; sce:YLL011W; -.
DR AGR; SGD:S000003934; -.
DR SGD; S000003934; SOF1.
DR VEuPathDB; FungiDB:YLL011W; -.
DR eggNOG; KOG0268; Eukaryota.
DR GeneTree; ENSGT00390000005711; -.
DR HOGENOM; CLU_033999_0_0_1; -.
DR InParanoid; P33750; -.
DR OMA; EDHNAYI; -.
DR OrthoDB; 5472351at2759; -.
DR BioCyc; YEAST:G3O-32116-MONOMER; -.
DR Reactome; R-SCE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 850649; 5 hits in 10 CRISPR screens.
DR PRO; PR:P33750; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; P33750; Protein.
DR GO; GO:0030686; C:90S preribosome; HDA:SGD.
DR GO; GO:0005730; C:nucleolus; IDA:SGD.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0032040; C:small-subunit processome; IDA:SGD.
DR GO; GO:0003729; F:mRNA binding; HDA:SGD.
DR GO; GO:0030490; P:maturation of SSU-rRNA; NAS:ComplexPortal.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR007287; Sof1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22851:SF0; DDB1- AND CUL4-ASSOCIATED FACTOR 13; 1.
DR PANTHER; PTHR22851; U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN; 1.
DR Pfam; PF04158; Sof1; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; WD repeat.
FT CHAIN 1..489
FT /note="Protein SOF1"
FT /id="PRO_0000051222"
FT REPEAT 65..105
FT /note="WD 1"
FT REPEAT 113..158
FT /note="WD 2"
FT REPEAT 177..214
FT /note="WD 3"
FT REPEAT 217..257
FT /note="WD 4"
FT REPEAT 259..299
FT /note="WD 5"
FT REPEAT 303..342
FT /note="WD 6"
FT REPEAT 346..385
FT /note="WD 7"
FT REGION 440..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 56789 MW; 4B28371CC61DE7E4 CRC64;
MKIKTIKRSA DDYVPVKSTQ ESQMPRNLNP ELHPFERARE YTKALNATKL ERMFAKPFVG
QLGYGHRDGV YAIAKNYGSL NKLATGSADG VIKYWNMSTR EEFVSFKAHY GLVTGLCVTQ
PRFHDKKPDL KSQNFMLSCS DDKTVKLWSI NVDDYSNKNS SDNDSVTNEE GLIRTFDGES
AFQGIDSHRE NSTFATGGAK IHLWDVNRLK PVSDLSWGAD NITSLKFNQN ETDILASTGS
DNSIVLYDLR TNSPTQKIVQ TMRTNAICWN PMEAFNFVTA NEDHNAYYYD MRNLSRSLNV
FKDHVSAVMD VDFSPTGDEI VTGSYDKSIR IYKTNHGHSR EIYHTKRMQH VFQVKYSMDS
KYIISGSDDG NVRLWRSKAW ERSNVKTTRE KNKLEYDEKL KERFRHMPEI KRISRHRHVP
QVIKKAQEIK NIELSSIKRR EANERRTRKD MPYISERKKQ IVGTVHKYED SGRDRKRRKE
DDKRDTQEK
//
