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Database: UniProt
Entry: P33905
LinkDB: P33905
Original site: P33905 
ID   TRAR_RHIRD              Reviewed;         234 AA.
AC   P33905;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   03-JUL-2019, entry version 123.
DE   RecName: Full=Transcriptional activator protein TraR;
GN   Name=traR;
OS   Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium
OS   radiobacter).
OG   Plasmid pTiA6NC.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=358;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A348;
RX   PubMed=8188582; DOI=10.1128/jb.176.10.2796-2806.1994;
RA   Fuqua W.C. Jr., Winans S.C.;
RT   "A LuxR-LuxI type regulatory system activates Agrobacterium Ti plasmid
RT   conjugal transfer in the presence of a plant tumor metabolite.";
RL   J. Bacteriol. 176:2796-2806(1994).
RN   [2]
RP   SEQUENCE REVISION.
RA   Winans S.C.;
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positive regulation of conjugal transfer of Ti plasmids.
CC       TraR activates target genes in the presence of AAI and also
CC       activates traR and traI themselves.
CC   -!- SIMILARITY: Belongs to the autoinducer-regulated transcriptional
CC       regulatory protein family. {ECO:0000305}.
DR   EMBL; L08596; AAA64793.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AF242881; AAC28121.1; -; Genomic_DNA.
DR   RefSeq; NP_059701.1; NC_002377.1.
DR   RefSeq; WP_010892389.1; NZ_LXKS01000002.1.
DR   PDB; 1H0M; X-ray; 3.00 A; A/B/C/D=1-234.
DR   PDB; 1L3L; X-ray; 1.66 A; A/B/C/D=1-234.
DR   PDBsum; 1H0M; -.
DR   PDBsum; 1L3L; -.
DR   SMR; P33905; -.
DR   BindingDB; P33905; -.
DR   ChEMBL; CHEMBL5865; -.
DR   DrugBank; DB08081; 3-OXO-OCTANOIC ACID (2-OXO-TETRAHYDRO-FURAN-3-YL)-AMIDE.
DR   PRIDE; P33905; -.
DR   GeneID; 1224220; -.
DR   GeneID; 39519238; -.
DR   OrthoDB; 1687028at2; -.
DR   EvolutionaryTrace; P33905; -.
DR   PRO; PR:P33905; -.
DR   CollecTF; EXPREG_00000a40; -.
DR   GO; GO:0032993; C:protein-DNA complex; IDA:CollecTF.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IDA:CollecTF.
DR   GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:CollecTF.
DR   GO; GO:0000746; P:conjugation; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   DisProt; DP00198; -.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.80; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR   InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03472; Autoind_bind; 1.
DR   Pfam; PF00196; GerE; 1.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF75516; SSF75516; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; Conjugation; DNA-binding; Plasmid;
KW   Quorum sensing; Transcription; Transcription regulation.
FT   CHAIN         1    234       Transcriptional activator protein TraR.
FT                                /FTId=PRO_0000184192.
FT   DOMAIN      167    232       HTH luxR-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00411}.
FT   DNA_BIND    191    210       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00411}.
FT   HELIX         4     11       {ECO:0000244|PDB:1L3L}.
FT   HELIX        18     31       {ECO:0000244|PDB:1L3L}.
FT   STRAND       35     43       {ECO:0000244|PDB:1L3L}.
FT   STRAND       46     51       {ECO:0000244|PDB:1L3L}.
FT   HELIX        55     63       {ECO:0000244|PDB:1L3L}.
FT   HELIX        66     68       {ECO:0000244|PDB:1L3L}.
FT   HELIX        71     78       {ECO:0000244|PDB:1L3L}.
FT   STRAND       83     86       {ECO:0000244|PDB:1L3L}.
FT   HELIX        87     90       {ECO:0000244|PDB:1L3L}.
FT   TURN         91     93       {ECO:0000244|PDB:1L3L}.
FT   HELIX        96    106       {ECO:0000244|PDB:1L3L}.
FT   TURN        107    109       {ECO:0000244|PDB:1L3L}.
FT   STRAND      111    119       {ECO:0000244|PDB:1L3L}.
FT   HELIX       121    123       {ECO:0000244|PDB:1L3L}.
FT   STRAND      125    136       {ECO:0000244|PDB:1L3L}.
FT   HELIX       145    161       {ECO:0000244|PDB:1L3L}.
FT   STRAND      167    169       {ECO:0000244|PDB:1L3L}.
FT   HELIX       176    185       {ECO:0000244|PDB:1L3L}.
FT   TURN        186    188       {ECO:0000244|PDB:1L3L}.
FT   HELIX       191    198       {ECO:0000244|PDB:1L3L}.
FT   HELIX       202    216       {ECO:0000244|PDB:1L3L}.
FT   HELIX       221    230       {ECO:0000244|PDB:1L3L}.
SQ   SEQUENCE   234 AA;  26734 MW;  1B0AEC296F1521A5 CRC64;
     MQHWLDKLTD LAAIEGDECI LKTGLADIAD HFGFTGYAYL HIQHRHITAV TNYHRQWQST
     YFDKKFEALD PVVKRARSRK HIFTWSGEHE RPTLSKDERA FYDHASDFGI RSGITIPIKT
     ANGFMSMFTM ASDKPVIDLD REIDAVAAAA TIGQIHARIS FLRTTPTAED AAWLDPKEAT
     YLRWIAVGKT MEEIADVEGV KYNSVRVKLR EAMKRFDVRS KAHLTALAIR RKLI
//
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