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Database: UniProt
Entry: P34668
LinkDB: P34668
Original site: P34668 
ID   YO12_CAEEL              Reviewed;         593 AA.
AC   P34668;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   24-OCT-2003, sequence version 2.
DT   16-OCT-2019, entry version 135.
DE   RecName: Full=Putative ATP-dependent RNA helicase ZK686.2;
DE            EC=3.6.4.13;
GN   ORFNames=ZK686.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M.,
RA   Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A.,
RA   Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A.,
RA   Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M.,
RA   Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N.,
RA   Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M.,
RA   Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R.,
RA   Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R.,
RA   Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K.,
RA   Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J.,
RA   Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Probable ATP-binding RNA helicase.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family.
CC       {ECO:0000305}.
DR   EMBL; FO080431; CCD63647.1; -; Genomic_DNA.
DR   PIR; D88511; D88511.
DR   PIR; S44912; S44912.
DR   RefSeq; NP_498690.2; NM_066289.5.
DR   SMR; P34668; -.
DR   STRING; 6239.ZK686.2; -.
DR   iPTMnet; P34668; -.
DR   EPD; P34668; -.
DR   PaxDb; P34668; -.
DR   PeptideAtlas; P34668; -.
DR   PRIDE; P34668; -.
DR   EnsemblMetazoa; ZK686.2.1; ZK686.2.1; WBGene00022792.
DR   GeneID; 176088; -.
DR   KEGG; cel:CELE_ZK686.2; -.
DR   UCSC; ZK686.2; c. elegans.
DR   CTD; 176088; -.
DR   WormBase; ZK686.2; CE34464; WBGene00022792; -.
DR   eggNOG; KOG0350; Eukaryota.
DR   eggNOG; ENOG410XRWM; LUCA.
DR   GeneTree; ENSGT00550000075141; -.
DR   HOGENOM; HOG000199518; -.
DR   InParanoid; P34668; -.
DR   KO; K14807; -.
DR   OMA; KFHPLAV; -.
DR   OrthoDB; 973872at2759; -.
DR   PhylomeDB; P34668; -.
DR   PRO; PR:P34668; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00022792; Expressed in 5 organ(s), highest expression level in germ line (C elegans).
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Reference proteome; RNA-binding.
FT   CHAIN         1    593       Putative ATP-dependent RNA helicase
FT                                ZK686.2.
FT                                /FTId=PRO_0000055095.
FT   DOMAIN      150    341       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      386    533       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     163    170       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       377    380       DEAD box.
SQ   SEQUENCE   593 AA;  66545 MW;  B13AB2CB7032E748 CRC64;
     MKRKNQKEDS DTENDDEIEP ANGDGIEQEM NRVTNGNEDD ESVGNDVAEP METEDVEDSG
     EVEIEETAQN GEREIFKVLG KQEMKNLEAL KVTSSWVQNA TTFSATIDSS TSQKLSQIEL
     PEHLTVPSAI STWFPVQYAV LPSLFFEIRS PPPLRPRDVA IAAPTGSGKT ICYVLPVLAA
     VGSKPSKILQ AVILVPVQTL VAQIVDEFKR WNDESGVAKV VSLSGANDFE KEARQLASDP
     PNVIVATPAR LVQHLTSKIP PPIDLSKLRF LIVDEADRMG KLMREEWLDL VEFLCGGMER
     VACLKDIIRQ RRAPQKIVLS ATLSKDVEEL HLWNLFKPRL FSATAVSVKD ITSGIPQVDH
     VSGRLALPSS ISHRLVVTDP KFHPLAVYQQ ITRNKFNRTL IFVNEVSSSN RLAHVLKELC
     KDQFEVDYFT AQLFGKRRYK MLEKFNKNEN RVLICSDVLA RGTDLNKVDC VINYNLPADD
     KLFVHRAGRT GRAGQDGYVI SVGDKESKRL FVKMLKVTNL WGDTVEEQME EYIFEKDMDR
     YSKALESLKA TVSSQAKTGG SRQIAKRSGF EAKRKSRPNA RGEKPWLKKK TTE
//
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