ID TA2R_RAT Reviewed; 341 AA.
AC P34978;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 27-MAR-2024, entry version 164.
DE RecName: Full=Thromboxane A2 receptor;
DE Short=TXA2-R;
DE AltName: Full=Prostanoid TP receptor;
DE AltName: Full=TXR2;
GN Name=Tbxa2r;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Kidney;
RX PubMed=7635958; DOI=10.1172/jci118108;
RA Abe T., Takeuchi K., Takahashi N., Tsutsumi E., Taniyama Y., Abe K.;
RT "Rat kidney thromboxane receptor: molecular cloning, signal transduction,
RT and intrarenal expression localization.";
RL J. Clin. Invest. 96:657-664(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=7696353; DOI=10.1016/0167-4889(94)00225-4;
RA Kitanaka J., Hashimoto H., Sugimoto Y., Sawada M., Negishi M., Suzumura A.,
RA Marunouchi T., Ichikawa A., Baba A.;
RT "cDNA cloning of a thromboxane A2 receptor from rat astrocytes.";
RL Biochim. Biophys. Acta 1265:220-223(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Kidney;
RX PubMed=8936585; DOI=10.1016/s0090-6980(96)00091-3;
RA D'Angelo D.D., Terasawa T., Carlisle S.J., Dorn G.W. II, Lynch K.R.;
RT "Characterization of a rat kidney thromboxane A2 receptor: high affinity
RT for the agonist ligand I-BOP.";
RL Prostaglandins 52:303-316(1996).
CC -!- FUNCTION: Receptor for thromboxane A2 (TXA2), a potent stimulator of
CC platelet aggregation. The activity of this receptor is mediated by a G-
CC protein that activates a phosphatidylinositol-calcium second messenger
CC system. In the kidney, the binding of TXA2 to glomerular TP receptors
CC causes intense vasoconstriction. Activates phospholipase C and adenylyl
CC cyclase.
CC -!- SUBUNIT: Interacts with RPGRIP1L. Interacts with RACK1; the interaction
CC regulates TBXA2R cell surface expression (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: In the brain, expressed in all types of glial
CC cells. In the kidney, expressed in the mesangial cells of the
CC glomerulus, smooth muscle cells of the renal arterioles, and in
CC transitional cell epithelium of renal pelvis.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; D21158; BAA04694.1; -; mRNA.
DR EMBL; D32080; BAA06844.1; -; mRNA.
DR PIR; I55623; I55623.
DR RefSeq; NP_058750.1; NM_017054.1.
DR RefSeq; XP_006240908.1; XM_006240846.2.
DR AlphaFoldDB; P34978; -.
DR SMR; P34978; -.
DR DIP; DIP-60433N; -.
DR IntAct; P34978; 1.
DR STRING; 10116.ENSRNOP00000027932; -.
DR BindingDB; P34978; -.
DR ChEMBL; CHEMBL3156; -.
DR GuidetoPHARMACOLOGY; 346; -.
DR GlyCosmos; P34978; 2 sites, No reported glycans.
DR GlyGen; P34978; 2 sites.
DR PhosphoSitePlus; P34978; -.
DR PaxDb; 10116-ENSRNOP00000027932; -.
DR Ensembl; ENSRNOT00000027932.5; ENSRNOP00000027932.2; ENSRNOG00000020585.7.
DR Ensembl; ENSRNOT00055056838; ENSRNOP00055046938; ENSRNOG00055032858.
DR Ensembl; ENSRNOT00060054255; ENSRNOP00060044969; ENSRNOG00060031270.
DR Ensembl; ENSRNOT00065037026; ENSRNOP00065029837; ENSRNOG00065021776.
DR GeneID; 24816; -.
DR KEGG; rno:24816; -.
DR UCSC; RGD:3825; rat.
DR AGR; RGD:3825; -.
DR CTD; 6915; -.
DR RGD; 3825; Tbxa2r.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234559; -.
DR HOGENOM; CLU_045991_3_0_1; -.
DR InParanoid; P34978; -.
DR OMA; HAILFDW; -.
DR OrthoDB; 5355693at2759; -.
DR PhylomeDB; P34978; -.
DR TreeFam; TF324982; -.
DR Reactome; R-RNO-391908; Prostanoid ligand receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-416482; G alpha (12/13) signalling events.
DR Reactome; R-RNO-428930; Thromboxane signalling through TP receptor.
DR PRO; PR:P34978; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000020585; Expressed in thymus and 19 other cell types or tissues.
DR Genevisible; P34978; RN.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:RGD.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004960; F:thromboxane receptor activity; IDA:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IMP:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0006954; P:inflammatory response; ISO:RGD.
DR GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; ISO:RGD.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IDA:RGD.
DR GO; GO:0030194; P:positive regulation of blood coagulation; IMP:RGD.
DR GO; GO:0045777; P:positive regulation of blood pressure; IMP:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; ISO:RGD.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.
DR GO; GO:0019229; P:regulation of vasoconstriction; ISO:RGD.
DR GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; ISO:RGD.
DR GO; GO:0007584; P:response to nutrient; IEP:RGD.
DR GO; GO:0033574; P:response to testosterone; IEP:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR GO; GO:0019932; P:second-messenger-mediated signaling; ISO:RGD.
DR GO; GO:0006939; P:smooth muscle contraction; ISO:RGD.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008365; Prostanoid_rcpt.
DR InterPro; IPR001105; Thbox_rcpt.
DR PANTHER; PTHR11866; G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER; 1.
DR PANTHER; PTHR11866:SF5; THROMBOXANE A2 RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01788; PROSTANOIDR.
DR PRINTS; PR00429; THROMBOXANER.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..341
FT /note="Thromboxane A2 receptor"
FT /id="PRO_0000070140"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..191
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..268
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..309
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 328
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P30987"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 188
FT /note="E -> G (in Ref. 2; BAA06844)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 341 AA; 36928 MW; E85843FE54C1CD94 CRC64;
MWLNSTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA GARPGAGPRS
SFLALLCGLV LTDFLGLLVT GAVVASQHAA LLDWRATDPG CRLCHFMGAA MVFFGLCPLL
LGAAMAAERF VGITRPFSRP AATSRRAWAT VGLVWVGAGT LGLLPLLGLG RYSVQYPGSW
CFLTLGAERG DVAFGLMFAL LGSVSVGLSL LLNTVSVATL CRVYHAREAT QRPRDCEVEM
MVQLVGIMVV ATVCWMPLLV FILQTLLQTL PVMSPSGQLL RTTERQLLIY LRVATWNQIL
DPWVYILFRR SVLRRLHPRF TSQLQAVSLH SPPTQAMLSG P
//
