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Database: UniProt
Entry: P36215
LinkDB: P36215
Original site: P36215 
ID   SODM_LITCT              Reviewed;          23 AA.
AC   P36215;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   05-DEC-2018, entry version 74.
DE   RecName: Full=Superoxide dismutase [Mn], mitochondrial;
DE            EC=1.15.1.1;
DE   Flags: Fragment;
OS   Lithobates catesbeiana (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana;
OC   Aquarana.
OX   NCBI_TaxID=8400;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RX   PubMed=3492965; DOI=10.1016/0003-9861(87)90657-6;
RA   Abe Y., Okazaki T.;
RT   "Purification and properties of the manganese superoxide dismutase
RT   from the liver of bullfrog, Rana catesbeiana.";
RL   Arch. Biochem. Biophys. 253:241-248(1987).
CC   -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC       produced within the cells and which are toxic to biological
CC       systems.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC       Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix.
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC       family. {ECO:0000305}.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   SUPFAM; SSF46609; SSF46609; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Manganese; Metal-binding; Mitochondrion;
KW   Oxidoreductase.
FT   CHAIN         1    >23       Superoxide dismutase [Mn], mitochondrial.
FT                                /FTId=PRO_0000159963.
FT   NON_TER      23     23
SQ   SEQUENCE   23 AA;  2594 MW;  5D80ED9B0E04F625 CRC64;
     KHTLPDLPYD FGALQPHISA EIM
//
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