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Database: UniProt
Entry: P37127
LinkDB: P37127
Original site: P37127 
ID   AEGA_ECOLI              Reviewed;         659 AA.
AC   P37127; P76560; P76970;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   10-APR-2019, entry version 160.
DE   RecName: Full=Protein AegA;
GN   Name=aegA; Synonyms=yffG; OrderedLocusNames=b2468, JW2452;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX   PubMed=8955321; DOI=10.1128/jb.178.23.6968-6974.1996;
RA   Cavicchioli R., Kolesnikow T., Gunsalus R.P.;
RT   "Characterization of the aegA locus of Escherichia coli: control of
RT   gene expression in response to anaerobiosis and nitrate.";
RL   J. Bacteriol. 178:6968-6974(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA   Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K.,
RA   Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N.,
RA   Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H.,
RA   Oshima T., Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S.,
RA   Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C.,
RA   Yamagata S., Horiuchi T.;
RT   "Construction of a contiguous 874-kb sequence of the Escherichia coli-
RT   K12 genome corresponding to 50.0-68.8 min on the linkage map and
RT   analysis of its sequence features.";
RL   DNA Res. 4:91-113(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA   Mau B., Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains
RT   MG1655 and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250};
CC       Note=Binds 4 [4Fe-4S] clusters. {ECO:0000250};
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB46944.1; Type=Frameshift; Positions=602; Evidence={ECO:0000305};
DR   EMBL; L34011; AAB46944.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; U00096; AAC75521.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA16342.2; -; Genomic_DNA.
DR   PIR; C65022; C65022.
DR   RefSeq; NP_416963.1; NC_000913.3.
DR   RefSeq; WP_001078880.1; NZ_LN832404.1.
DR   ProteinModelPortal; P37127; -.
DR   SMR; P37127; -.
DR   BioGrid; 4260929; 10.
DR   DIP; DIP-9060N; -.
DR   IntAct; P37127; 6.
DR   STRING; 511145.b2468; -.
DR   jPOST; P37127; -.
DR   PaxDb; P37127; -.
DR   PRIDE; P37127; -.
DR   EnsemblBacteria; AAC75521; AAC75521; b2468.
DR   EnsemblBacteria; BAA16342; BAA16342; BAA16342.
DR   GeneID; 947383; -.
DR   KEGG; ecj:JW2452; -.
DR   KEGG; eco:b2468; -.
DR   PATRIC; fig|1411691.4.peg.4272; -.
DR   EchoBASE; EB2308; -.
DR   EcoGene; EG12409; aegA.
DR   eggNOG; ENOG4105BZ8; Bacteria.
DR   eggNOG; COG0493; LUCA.
DR   eggNOG; COG1142; LUCA.
DR   HOGENOM; HOG000031439; -.
DR   InParanoid; P37127; -.
DR   PhylomeDB; P37127; -.
DR   BioCyc; EcoCyc:EG12409-MONOMER; -.
DR   BioCyc; ECOL316407:JW2452-MONOMER; -.
DR   PRO; PR:P37127; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016639; F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.1060.10; -; 1.
DR   Gene3D; 3.50.50.60; -; 3.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR006006; Glut_synth_ssu2.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   Pfam; PF13247; Fer4_11; 1.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   TIGRFAMs; TIGR01318; gltD_gamma_fam; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 5.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding;
KW   Oxidoreductase; Reference proteome; Repeat.
FT   CHAIN         1    659       Protein AegA.
FT                                /FTId=PRO_0000170801.
FT   DOMAIN        3     32       4Fe-4S ferredoxin-type 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   DOMAIN       47     77       4Fe-4S ferredoxin-type 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   DOMAIN       78    107       4Fe-4S ferredoxin-type 3.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   DOMAIN      114    147       4Fe-4S ferredoxin-type 4.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        12     12       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL        15     15       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL        18     18       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL        22     22       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL        56     56       Iron-sulfur 3 (4Fe-4S). {ECO:0000250}.
FT   METAL        59     59       Iron-sulfur 3 (4Fe-4S). {ECO:0000250}.
FT   METAL        64     64       Iron-sulfur 3 (4Fe-4S). {ECO:0000250}.
FT   METAL        68     68       Iron-sulfur 4 (4Fe-4S). {ECO:0000250}.
FT   METAL        87     87       Iron-sulfur 4 (4Fe-4S). {ECO:0000250}.
FT   METAL        90     90       Iron-sulfur 4 (4Fe-4S). {ECO:0000250}.
FT   METAL        93     93       Iron-sulfur 4 (4Fe-4S). {ECO:0000250}.
FT   METAL        97     97       Iron-sulfur 3 (4Fe-4S). {ECO:0000250}.
FT   METAL       121    121       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       124    124       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       133    133       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       137    137       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   CONFLICT    488    488       L -> R (in Ref. 1; AAB46944).
FT                                {ECO:0000305}.
FT   CONFLICT    513    513       V -> A (in Ref. 1; AAB46944).
FT                                {ECO:0000305}.
FT   CONFLICT    600    600       W -> M (in Ref. 1). {ECO:0000305}.
SQ   SEQUENCE   659 AA;  71844 MW;  DD3ADF3E90218402 CRC64;
     MNRFIMANSQ QCLGCHACEI ACVMAHNDEQ HVLSQHHFHP RITVIKHQQQ RSAVTCHHCE
     DAPCARSCPN GAISHVDDSI QVNQQKCIGC KSCVVACPFG TMQIVLTPVA AGKVKATAHK
     CDLCAGRENG PACVENCPAD ALQLVTDVAL SGMAKSRRLR TARQEHQPWH ASTAAQEMPV
     MSKVEQMQAT PARGEPDKLA IEARKTGFDE IYLPFRADQA QREASRCLKC GEHSVCEWTC
     PLHNHIPQWI ELVKAGNIDA AVELSHQTNT LPEITGRVCP QDRLCEGACT IRDEHGAVTI
     GNIERYISDQ ALAKGWRPDL SHVTKVDKRV AIIGAGPAGL ACADVLTRNG VGVTVYDRHP
     EIGGLLTFGI PSFKLDKSLL ARRREIFSAM GIHFELNCEV GKDVSLDSLL EQYDAVFVGV
     GTYRSMKAGL PNEDAPGVYD ALPFLIANTK QVMGLEELPE EPFINTAGLN VVVLGGGDTA
     MDCVRTALRH GASNVTCAYR RDEANMPGSK KEVKNAREEG ANFEFNVQPV ALELNEQGHV
     CGIRFLRTRL GEPDAQGRRR PVPVEGSEFV MPADAVIMAF GFNPHGMPWL ESHGVTVDKW
     GRIIADVESQ YRYQTTNPKI FAGGDAVRGA DLVVTAMAEG RHAAQGIIDW LGVKSVKSH
//
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