ID MODC1_AZOVI Reviewed; 361 AA.
AC P37732;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 13-SEP-2023, entry version 121.
DE RecName: Full=Molybdenum import ATP-binding protein ModC 1 {ECO:0000255|HAMAP-Rule:MF_01705};
DE EC=7.3.2.5 {ECO:0000255|HAMAP-Rule:MF_01705};
GN Name=modC1 {ECO:0000255|HAMAP-Rule:MF_01705}; Synonyms=modC, modD;
OS Azotobacter vinelandii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Azotobacter.
OX NCBI_TaxID=354;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DJ35;
RX PubMed=8384683; DOI=10.1111/j.1365-2958.1993.tb01136.x;
RA Luque F., Mitchenall L.A., Chapman M., Christine R., Pau R.N.;
RT "Characterization of genes involved in molybdenum transport in Azotobacter
RT vinelandii.";
RL Mol. Microbiol. 7:447-459(1993).
RN [2]
RP GENE NAME.
RX PubMed=7665518; DOI=10.1128/jb.177.18.5294-5302.1995;
RA Mouncey N.J., Mitchenall L.A., Pau R.N.;
RT "Mutational analysis of genes of the mod locus involved in molybdenum
RT transport, homeostasis, and processing in Azotobacter vinelandii.";
RL J. Bacteriol. 177:5294-5302(1995).
CC -!- FUNCTION: Part of the ABC transporter complex ModABC involved in
CC molybdenum import. Responsible for energy coupling to the transport
CC system. {ECO:0000255|HAMAP-Rule:MF_01705}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + molybdate(out) = ADP + H(+) + molybdate(in) +
CC phosphate; Xref=Rhea:RHEA:22020, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36264,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.3.2.5;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01705};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (ModC),
CC two transmembrane proteins (ModB) and a solute-binding protein (ModA).
CC {ECO:0000255|HAMAP-Rule:MF_01705}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01705}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01705}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Molybdate
CC importer (TC 3.A.1.8) family. {ECO:0000255|HAMAP-Rule:MF_01705}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA48821.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X69077; CAA48821.1; ALT_INIT; Genomic_DNA.
DR PIR; S31045; S31045.
DR RefSeq; WP_012703506.1; NZ_FPKM01000015.1.
DR AlphaFoldDB; P37732; -.
DR SMR; P37732; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0015412; F:ABC-type molybdate transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR InterPro; IPR011868; ModC_ABC_ATP-bd.
DR InterPro; IPR004606; Mop_domain.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005116; Transp-assoc_OB_typ1.
DR NCBIfam; TIGR02142; modC_ABC; 1.
DR PANTHER; PTHR43514; ABC TRANSPORTER I FAMILY MEMBER 10; 1.
DR PANTHER; PTHR43514:SF10; MOLYBDENUM IMPORT ATP-BINDING PROTEIN MODC 2; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF03459; TOBE; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF50331; MOP-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51241; MODC; 1.
DR PROSITE; PS51866; MOP; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane; Molybdenum;
KW Nucleotide-binding; Translocase; Transport.
FT CHAIN 1..361
FT /note="Molybdenum import ATP-binding protein ModC 1"
FT /id="PRO_0000092528"
FT DOMAIN 1..237
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01705"
FT DOMAIN 296..361
FT /note="Mop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01213"
FT BINDING 35..42
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01705"
SQ SEQUENCE 361 AA; 39769 MW; 06E2ADA0C03BE4A9 CRC64;
MPADGIRARF RVDYAGFALD VDLTLPGHGV TALFGHSGSG KTTLLRCVAG LERAAEARLE
INGELWQDSA AGVFLPTHRR ALGYVFQEAS LFPHLSVRRN LEYGMKRVDA ASRQVSWERV
LELLGIGHLL ERLPGRLSGG ERQRVGIARA LLTSPRLLLM DEPLAALDLK RKNEILPYLE
RLHDELDIPM LFVSHLPDEV ARLADHVVLL DQGRVTAQGS LQDIMARLDL PTAFHEDAGV
VIESVVAEHD DHYHLTRLAF PGGAVLVARR PEAPGQRLRL RVHARDVSLA NSRIEDSSIT
NVLPATVREV VEADTPAHVL VRLEAEGTPL IARITRRSCD QLGIAPGRRM WAQIKAVALL
G
//
