ID YUSZ_BACSU Reviewed; 280 AA.
AC P37959; O34907;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 27-MAR-2024, entry version 126.
DE RecName: Full=Uncharacterized oxidoreductase YusZ;
DE EC=1.-.-.-;
DE AltName: Full=ORFA;
GN Name=yusZ; Synonyms=yvxA; OrderedLocusNames=BSU32980;
OS Bacillus subtilis (strain 168).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9353931; DOI=10.1099/00221287-143-10-3305;
RA Medina N., Vannier F., Roche B., Autret S., Levine A., Seror S.J.;
RT "Sequencing of regions downstream of addA (98 degrees) and citG (289
RT degrees) in Bacillus subtilis.";
RL Microbiology 143:3305-3308(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 157-280.
RX PubMed=8396117; DOI=10.1128/jb.175.17.5428-5437.1993;
RA Chen L., James L.P., Helmann J.D.;
RT "Metalloregulation in Bacillus subtilis: isolation and characterization of
RT two genes differentially repressed by metal ions.";
RL J. Bacteriol. 175:5428-5437(1993).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; Z93941; CAB07971.1; -; Genomic_DNA.
DR EMBL; L19547; AAA68041.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15287.1; -; Genomic_DNA.
DR EMBL; Z22928; CAA80509.1; -; Genomic_DNA.
DR PIR; C70023; C70023.
DR RefSeq; NP_391177.1; NC_000964.3.
DR RefSeq; WP_003228540.1; NZ_JNCM01000033.1.
DR AlphaFoldDB; P37959; -.
DR SMR; P37959; -.
DR STRING; 224308.BSU32980; -.
DR PaxDb; 224308-BSU32980; -.
DR EnsemblBacteria; CAB15287; CAB15287; BSU_32980.
DR GeneID; 938596; -.
DR KEGG; bsu:BSU32980; -.
DR PATRIC; fig|224308.179.peg.3574; -.
DR eggNOG; COG1028; Bacteria.
DR InParanoid; P37959; -.
DR OrthoDB; 9775296at2; -.
DR PhylomeDB; P37959; -.
DR BioCyc; BSUB:BSU32980-MONOMER; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd05374; 17beta-HSD-like_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43976:SF16; NAD(P)-BINDING PROTEIN; 1.
DR PANTHER; PTHR43976; SHORT CHAIN DEHYDROGENASE; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..280
FT /note="Uncharacterized oxidoreductase YusZ"
FT /id="PRO_0000054849"
FT ACT_SITE 152
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 3..29
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 139
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CONFLICT 157..177
FT /note="HALEGFSESLRIELLPFGIET -> MHWKVFLKACVSSCFRSVSKA (in
FT Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 202..203
FT /note="AD -> RA (in Ref. 3; AAA68041/CAA80509)"
FT /evidence="ECO:0000305"
FT CONFLICT 225
FT /note="S -> I (in Ref. 3; AAA68041/CAA80509)"
FT /evidence="ECO:0000305"
FT CONFLICT 242..243
FT /note="QH -> HD (in Ref. 3; AAA68041/CAA80509)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 280 AA; 30789 MW; 3F778B41AD462045 CRC64;
MNKKIAIVTG ASSGFGLLAA VKLARSFFVI ATSRQPEKAE QLRELAAAHN VSDSIHITAL
DVTDEQSIVS FGKAVSAYAP IDLLVNNAGT AYGGFIEDVP MEHFRQQFET NVFGVIHVTK
TVLPYIRKHG GAKIINVSSI SGLTGFPALS PYVSSKHALE GFSESLRIEL LPFGIETALI
EPGSYKTSIW STSLSNFMSV PADDSAYHQY YKKILSYVQK NGEESGDPQE VADLIYQLAT
KQHIKNLRYP IGKGIKLTLL FRSLFPWSAW ESILKKKLFS
//
