ID P3IP1_DANRE Reviewed; 263 AA.
AC Q7SXB3;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=Phosphoinositide-3-kinase-interacting protein 1;
DE AltName: Full=Kringle domain-containing protein HGFL;
DE Flags: Precursor;
GN Name=pik3ip1; Synonyms=hgfl; ORFNames=zgc:66482;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB; TISSUE=Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of hepatic phosphatidylinositol 3-kinase
CC (PI3K) activity. {ECO:0000250|UniProtKB:Q7TMJ8}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96FE7};
CC Single-pass type I membrane protein {ECO:0000255}.
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DR EMBL; BC055675; AAH55675.1; -; mRNA.
DR EMBL; BC067191; AAH67191.1; -; mRNA.
DR RefSeq; NP_938188.1; NM_198374.1.
DR AlphaFoldDB; Q7SXB3; -.
DR SMR; Q7SXB3; -.
DR STRING; 7955.ENSDARP00000115818; -.
DR GlyCosmos; Q7SXB3; 1 site, No reported glycans.
DR PaxDb; 7955-ENSDARP00000115818; -.
DR GeneID; 386643; -.
DR KEGG; dre:386643; -.
DR AGR; ZFIN:ZDB-GENE-031030-14; -.
DR CTD; 113791; -.
DR ZFIN; ZDB-GENE-031030-14; pik3ip1.
DR eggNOG; ENOG502QTWD; Eukaryota.
DR InParanoid; Q7SXB3; -.
DR OrthoDB; 2881180at2759; -.
DR PhylomeDB; Q7SXB3; -.
DR PRO; PR:Q7SXB3; -.
DR Proteomes; UP000000437; Chromosome 5.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004175; F:endopeptidase activity; IBA:GO_Central.
DR GO; GO:0036313; F:phosphatidylinositol 3-kinase catalytic subunit binding; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IBA:GO_Central.
DR CDD; cd00108; KR; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR PANTHER; PTHR24261:SF16; PHOSPHOINOSITIDE-3-KINASE-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR24261; PLASMINOGEN-RELATED; 1.
DR Pfam; PF00051; Kringle; 1.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00130; KR; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Kringle; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..263
FT /note="Phosphoinositide-3-kinase-interacting protein 1"
FT /id="PRO_0000280351"
FT TOPO_DOM 19..163
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 24..99
FT /note="Kringle"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT REGION 239..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 25..99
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT DISULFID 46..80
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT DISULFID 69..94
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
SQ SEQUENCE 263 AA; 28777 MW; 8BEBC117EC7C8A58 CRC64;
MFGRLYFMLL LSVGLVDCLS VVKDCITNNG EDYRGTQQKT SSGSTCLSWR SLNLKFKDSQ
TGVGDHNFCR NPDGSNKPWC YVSGSSGETK KEACDIRICQ DQNATEAPAP EESVPTQGLT
QRMVETFEPA NSFPSQVEGA AVQPVKGVRQ QVRSGPKKKK DLGTLGYVLA VFMMAIIILL
GGGITMGYFY KRGRDLKKQH EQRVYEREMH RITLPLSAFA NPTCELVDEN TIVITAEPNN
QTPTQEPVEG ADPLMGSAGT PGA
//
