GenomeNet

Database: UniProt
Entry: P40889
LinkDB: P40889
Original site: P40889 
ID   YJW5_YEAST              Reviewed;        1758 AA.
AC   P40889; D6VVX3; P40887; Q05371; Q9UQW2;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   11-DEC-2019, entry version 138.
DE   RecName: Full=Y' element ATP-dependent helicase YJL225C;
DE            EC=3.6.4.12;
GN   OrderedLocusNames=YJL225C; ORFNames=HRF393/HRD1054, HRF393/HRD732, J0202;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7725802; DOI=10.1002/yea.320101216;
RA   Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.;
RT   "Sequence analysis of a 40.2 kb DNA fragment located near the left telomere
RT   of yeast chromosome X.";
RL   Yeast 10:1657-1662(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=9837911; DOI=10.1074/jbc.273.50.33360;
RA   Yamada M., Hayatsu N., Matsuura A., Ishikawa F.;
RT   "Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is
RT   induced in survivors defective for telomerase.";
RL   J. Biol. Chem. 273:33360-33366(1998).
CC   -!- FUNCTION: Catalyzes DNA unwinding and is involved in telomerase-
CC       independent telomere maintenance. {ECO:0000269|PubMed:9837911}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- INDUCTION: Induced in absence of telomerase TLC1.
CC       {ECO:0000269|PubMed:9837911}.
CC   -!- SIMILARITY: Belongs to the helicase family. Yeast subtelomeric Y'
CC       repeat subfamily. {ECO:0000305}.
DR   EMBL; Z48148; CAA88141.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; Z48148; CAA88142.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; Z34098; CAA83986.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; Z34098; CAA83985.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; Z49498; CAA89520.1; -; Genomic_DNA.
DR   EMBL; Z49500; CAA89522.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08589.1; -; Genomic_DNA.
DR   PIR; S57015; S57015.
DR   RefSeq; NP_012311.1; NM_001181657.1.
DR   BioGrid; 33558; 4.
DR   DIP; DIP-4705N; -.
DR   STRING; 4932.YJL225C; -.
DR   PaxDb; P40889; -.
DR   PRIDE; P40889; -.
DR   EnsemblFungi; YJL225C_mRNA; YJL225C; YJL225C.
DR   GeneID; 853231; -.
DR   KEGG; sce:YJL225C; -.
DR   EuPathDB; FungiDB:YJL225C; -.
DR   SGD; S000003760; YJL225C.
DR   HOGENOM; HOG000155528; -.
DR   BioCyc; YEAST:G3O-31646-MONOMER; -.
DR   PRO; PR:P40889; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; P40889; protein.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004386; F:helicase activity; ISS:SGD.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR021646; Sir1_ORC-binding.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF11603; Sir1; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome;
KW   Repeat.
FT   CHAIN           1..1758
FT                   /note="Y' element ATP-dependent helicase YJL225C"
FT                   /id="PRO_0000102208"
FT   DOMAIN          668..845
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          900..1051
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   NP_BIND         681..688
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   1758 AA;  197565 MW;  7E1D052AF97F8CA0 CRC64;
     MKVSDRRKFE KANFDEFESA LNNKNDLVHC PSITLFESIP TEVRSFYEDE KSGLIKVVKF
     RTGAMDRKRS FEKVVISVMV GKNVKKFLTF VEDEPDFQGG PIPSKYLIPK KINLMVYTLF
     QVHTLKFNRK DYDTLSLFYL NRGYYNELSF RVLERCHEIA SARPNDSSTM RTFTDFVSGA
     PIVRSLQKST IRKYGYNLAP YMFLLLHVDE LSIFSAYQAS LPGEKKVDTE RLKRDLCPRK
     PIEIKYFSQI CNDMMNKKDR LGDILHIILR ACALNFGAGP RGGAGDEEDR SITNEEPIIP
     SVDEHGLKVC KLRSPNTPRR LRKTLDAVKA LLVSSCACTA RDLDIFDDNN GVAMWKWIKI
     LYHEVAQETT LKDSYRITLV PSSDGISLLA FAGPQRNVYV DDTTRRIQLY TDYNKNGSSE
     PRLKTLDGLT SDYVFYFVTV LRQMQICALG NSYDAFNHDP WMDVVGFEDP NQVTNRDISR
     IVLYSYMFLN TAKGCLVEYA TFRQYMRELP KNAPQKLNFR EMRQGLIALG RHCVGSRFET
     DLYESATSEL MANHSVQTGR NIYGVDSFSL TSVSGTTATL LQERASERWI QWLGLESDYH
     CSFSSTRNAE DVVAGEAASS NHHQKISRVT RKRPREPKST NDILVAGQKL FGSSFEFRDL
     HQLRLCYEIY MADTPSVAVQ APPGYGKTEL FHLPLIALAS KGDVEYVSFL FVPYTVLLAN
     CMIRLGRRGC LNVAPVRNFI EEGYDGVTDL YVGIYDDLAS TNFTDRIAAW ENIVECTFRT
     NNVKLGYLIV DEFHNFETEV YRQSQFGGIT NLDFDAFEKA IFLSGTAPEA VADAALQRIG
     LTGLAKKSMD INELKRSEDL SRGLSSYPTR MFNLIKEKSE VPLGHVHKIR KKVESQPEEA
     LKLLLALFES EPESKAIVVA STTNEVEELA CSWRKYFRVV WIHGKLGAAE KVSRTKEFVT
     DGSMQVLIGT KLVTEGIDIK QLMMVIMLDN RLNIIELIQG VGRLRDGGLC YLLSRKNSWA
     ARNRKGELPP IKEGCITEQV REFYGLESKK GKKGQHVGCC GSRTDLSADT VELIERMDRL
     AEKQATASMS IVALPSSFQE SNSSDRYRKY CSSDEDSNTC IHGSANASTN ASTNAITTAS
     TNVRTNATTN ASTNATTNAS TNASTNATTN ASTNATTNSS TNATTTASTN VRTSATTTAS
     INVRTSATTT ESTNSSTNAT TTESTNSSTN ATTTESTNSN TSATTTASIN VRTSATTTES
     TNSSTSATTT ASINVRTSAT TTKSINSSTN ATTTESTNSN TNATTTESTN SSTNATTTES
     TNSSTNATTT ESTNSNTSAA TTESTNSNTS ATTTESTNAS AKEDANKDGN AEDNRFHPVT
     DINKESYKRK GSQMVLLERK KLKAQFPNTS ENMNVLQFLG FRSDEIKHLF LYGIDIYFCP
     EGVFTQYGLC KGCQKMFELC VCWAGQKVSY RRIAWEALAV ERMLRNDEEY KEYLEDIEPY
     HGDPVGYLKY FSVKRREIYS QIQRNYAWYL AITRRRETIS VLDSTRGKQG SQVFRMSGRQ
     IKELYFKVWS NLRESKTEVL QYFLNWDEKK CQEEWEAKDD TVVVEALEKG GVFQRLRSMT
     SAGLQGPQYV KLQFSRHHRQ LRSRYELSLG MHLRDQIALG VTPSKVPHWT AFLSMLIGLF
     YNKTFRQKLE YLLEQISEVW LLPHWLDLAN VEVLAADDTR VPLYMLMVAV HKELDSDDVP
     DGRFDILLCR DSSREVGE
//
DBGET integrated database retrieval system