ID IAP_GVCPM Reviewed; 275 AA.
AC P41436;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Apoptosis inhibitor IAP;
GN Name=IAP;
OS Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia
OS pomonella granulovirus).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Betabaculovirus;
OC Betabaculovirus cypomonellae.
OX NCBI_TaxID=654905;
OH NCBI_TaxID=82600; Cydia pomonella (Codling moth).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Mexican 1;
RX PubMed=8445726; DOI=10.1128/jvi.67.4.2168-2174.1993;
RA Crook N.E., Clem R.J., Miller L.K.;
RT "An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif.";
RL J. Virol. 67:2168-2174(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Mexican 1;
RX PubMed=9237352; DOI=10.1023/a:1007917317770;
RA Kang W., Crook N.E., Winstanley D., O'Reilly D.R.;
RT "Complete sequence and transposon mutagenesis of the BamHI J fragment of
RT Cydia pomonella granulosis virus.";
RL Virus Genes 14:131-136(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Mexican 1;
RX PubMed=11562546; DOI=10.1099/0022-1317-82-10-2531;
RA Luque T., Finch R., Crook N., O'Reilly D.R., Winstanley D.;
RT "The complete sequence of the Cydia pomonella granulovirus genome.";
RL J. Gen. Virol. 82:2531-2547(2001).
CC -!- FUNCTION: Acts by blocking cellular apoptosis rather than by preventing
CC viral stimulation of apoptosis.
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DR EMBL; U53466; AAB39098.1; -; Genomic_DNA.
DR PIR; A45679; A45679.
DR RefSeq; NP_148801.1; NC_002816.1.
DR SMR; P41436; -.
DR MEROPS; I32.010; -.
DR GeneID; 921387; -.
DR KEGG; vg:921387; -.
DR Proteomes; UP000009249; Segment.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00022; BIR; 2.
DR CDD; cd16510; RING-HC_IAPs; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001370; BIR_rpt.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10044:SF139; DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2; 1.
DR PANTHER; PTHR10044; INHIBITOR OF APOPTOSIS; 1.
DR Pfam; PF00653; BIR; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00238; BIR; 2.
DR SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 2.
DR PROSITE; PS01282; BIR_REPEAT_1; 2.
DR PROSITE; PS50143; BIR_REPEAT_2; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Apoptosis; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..275
FT /note="Apoptosis inhibitor IAP"
FT /id="PRO_0000122372"
FT REPEAT 7..73
FT /note="BIR 1"
FT REPEAT 108..175
FT /note="BIR 2"
FT ZN_FING 228..263
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT BINDING 145
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 148
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 165
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT BINDING 172
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
SQ SEQUENCE 275 AA; 31290 MW; 84605448869CAD60 CRC64;
MSDLRLEEVR LNTFEKWPVS FLSPETMAKN GFYYLGRSDE VRCAFCKVEI MRWKEGEDPA
ADHKKWAPQC PFVKGIDVCG SIVTTNNIQN TTTHDTIIGP AHPKYAHEAA RVKSFHNWPR
CMKQRPEQMA DAGFFYTGYG DNTKCFYCDG GLKDWEPEDV PWEQHVRWFD RCAYVQLVKG
RDYVQKVITE ACVLPGENTT VSTAAPVSEP IPETKIEKEP QVEDSKLCKI CYVEECIVCF
VPCGHVVACA KCALSVDKCP MCRKIVTSVL KVYFS
//
