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Database: UniProt
Entry: P42948
LinkDB: P42948
Original site: P42948 
ID   SET4_YEAST              Reviewed;         560 AA.
AC   P42948; D6VW79;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   13-FEB-2019, entry version 133.
DE   RecName: Full=SET domain-containing protein 4;
GN   Name=SET4; OrderedLocusNames=YJL105W; ORFNames=J0819;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=7483851; DOI=10.1002/yea.320110909;
RA   Rasmussen S.W.;
RT   "A 37.5 kb region of yeast chromosome X includes the SME1, MEF2, GSH1
RT   and CSD3 genes, a TCP-1-related gene, an open reading frame similar to
RT   the DAL80 gene, and a tRNA(Arg).";
RL   Yeast 11:873-883(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N.,
RA   Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H.,
RA   Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A.,
RA   Hennemann A., Herbert C.J., Heumann K., Hilger F., Hollenberg C.P.,
RA   Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L.,
RA   Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V.,
RA   Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M.,
RA   Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W.,
RA   Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M.,
RA   Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A.,
RA   Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M.,
RA   Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
RA   Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and
RT   now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- FUNCTION: Putative chromatin regulator.
CC   -!- SIMILARITY: Belongs to the SET3 family. {ECO:0000305}.
DR   EMBL; X85021; CAA59389.1; -; Genomic_DNA.
DR   EMBL; Z49380; CAA89400.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08695.1; -; Genomic_DNA.
DR   PIR; S53382; S53382.
DR   RefSeq; NP_012430.1; NM_001181538.1.
DR   ProteinModelPortal; P42948; -.
DR   BioGrid; 33651; 101.
DR   MINT; P42948; -.
DR   STRING; 4932.YJL105W; -.
DR   CarbonylDB; P42948; -.
DR   PaxDb; P42948; -.
DR   PRIDE; P42948; -.
DR   EnsemblFungi; YJL105W_mRNA; YJL105W_mRNA; YJL105W.
DR   GeneID; 853339; -.
DR   KEGG; sce:YJL105W; -.
DR   EuPathDB; FungiDB:YJL105W; -.
DR   SGD; S000003641; SET4.
DR   GeneTree; ENSGT00940000168747; -.
DR   InParanoid; P42948; -.
DR   KO; K07117; -.
DR   OMA; THNESSK; -.
DR   BioCyc; YEAST:G3O-31559-MONOMER; -.
DR   PRO; PR:P42948; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Complete proteome; Metal-binding;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN         1    560       SET domain-containing protein 4.
FT                                /FTId=PRO_0000097697.
FT   DOMAIN      346    475       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   ZN_FING     160    210       PHD-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00146}.
SQ   SEQUENCE   560 AA;  63856 MW;  9A7BAECE97318AFA CRC64;
     MTSPESLSSR HIRQGRTYTT TDKVISRSSS YSSNSSMSKD YGDHTPLSVS SAASETLPSP
     QYMPIRTFNT MPTAGPTPLH LFQNDRGIFN HHSSSGSSKT ASTNKRGIAA AVALATAATI
     PFPLKKQNQD DNSKVSVTHN ESSKENKITP SMRAEDNKPK NGCICGSSDS KDELFIQCNK
     CKTWQHKLCY AFKKSDPIKR DFVCKRCDSD TKVQVNQVKP MIFPRKMGDE RLFQFSSIVT
     TSASNTNQHQ QSVNNIEEQP KKRQLHYTAP TTENSNSIRK KLRQEKLVVS SHFLKPLLNE
     VSSSNDTEFK AITISEYKDK YVKMFIDNHY DDDWVVCSNW ESSRSADIEV RKSSNERDFG
     VFAADSCVKG ELIQEYLGKI DFQKNYQTDP NNDYRLMGTT KPKVLFHPHW PLYIDSRETG
     GLTRYIRRSC EPNVELVTVR PLDEKPRGDN DCRVKFVLRA IRDIRKGEEI SVEWQWDLRN
     PIWEIINASK DLDSLPDPDK FWLMGSIKTI LTNCDCACGY LGHNCPITKI KNFSEEFMRN
     TKESLSNKSY FNTIMHNCKP
//
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