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Database: UniProt
Entry: P43610
LinkDB: P43610
Original site: P43610 
ID   IRC5_YEAST              Reviewed;         853 AA.
AC   P43610; D6VTS1;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 2.
DT   16-OCT-2019, entry version 159.
DE   RecName: Full=Uncharacterized ATP-dependent helicase IRC5;
DE            EC=3.6.4.-;
DE   AltName: Full=Increased recombination centers protein 5;
GN   Name=IRC5; OrderedLocusNames=YFR038W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   PubMed=8686381;
RX   DOI=10.1002/(sici)1097-0061(199602)12:2<177::aid-yea896>3.0.co;2-a;
RA   Eki T., Naitou M., Hagiwara H., Abe M., Ozawa M., Sasanuma S.,
RA   Sasanuma M., Tsuchiya Y., Shibata T., Watanabe K., Ono A.,
RA   Yamazaki M., Tashiro H., Hanaoka F., Murakami Y.;
RT   "Fifteen open reading frames in a 30.8 kb region of the right arm of
RT   chromosome VI from Saccharomyces cerevisiae.";
RL   Yeast 12:177-190(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7670463; DOI=10.1038/ng0795-261;
RA   Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M.,
RA   Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K.,
RA   Yamazaki M., Tashiro H., Eki T.;
RT   "Analysis of the nucleotide sequence of chromosome VI from
RT   Saccharomyces cerevisiae.";
RL   Nat. Genet. 10:261-268(1995).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
RA   Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and
RT   now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   IDENTIFICATION OF FRAMESHIFT.
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA   Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA   Gates K., Gaffney T.D., Philippsen P.;
RT   "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT   comparison to the genome of a related fungus: Ashbya gossypii.";
RL   Genome Biol. 4:R45.1-R45.13(2003).
RN   [5]
RP   IDENTIFICATION OF FRAMESHIFT.
RX   PubMed=12748633; DOI=10.1038/nature01644;
RA   Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT   "Sequencing and comparison of yeast species to identify genes and
RT   regulatory elements.";
RL   Nature 423:241-254(2003).
RN   [6]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=18085829; DOI=10.1371/journal.pgen.0030228;
RA   Alvaro D., Lisby M., Rothstein R.;
RT   "Genome-wide analysis of Rad52 foci reveals diverse mechanisms
RT   impacting recombination.";
RL   PLoS Genet. 3:E228-E228(2007).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA   Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA   Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-
RT   terminal acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to
CC       genomic integrity.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Displays increased levels of spontaneous
CC       RAD52 foci in proliferating diploid cells.
CC       {ECO:0000269|PubMed:18085829}.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA09277.1; Type=Frameshift; Evidence={ECO:0000305};
DR   EMBL; D50617; BAA09277.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; BK006940; DAA12481.1; -; Genomic_DNA.
DR   PIR; S56293; S56293.
DR   RefSeq; NP_116696.2; NM_001180003.1.
DR   SMR; P43610; -.
DR   BioGrid; 31196; 69.
DR   DIP; DIP-5300N; -.
DR   IntAct; P43610; 1.
DR   MINT; P43610; -.
DR   STRING; 4932.YFR038W; -.
DR   iPTMnet; P43610; -.
DR   MaxQB; P43610; -.
DR   PaxDb; P43610; -.
DR   PRIDE; P43610; -.
DR   EnsemblFungi; YFR038W_mRNA; YFR038W; YFR038W.
DR   GeneID; 850599; -.
DR   KEGG; sce:YFR038W; -.
DR   EuPathDB; FungiDB:YFR038W; -.
DR   SGD; S000001934; IRC5.
DR   InParanoid; P43610; -.
DR   KO; K19001; -.
DR   OMA; YNISEIM; -.
DR   BioCyc; YEAST:G3O-30485-MONOMER; -.
DR   PRO; PR:P43610; -.
DR   Proteomes; UP000002311; Chromosome VI.
DR   GO; GO:0005634; C:nucleus; HDA:SGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATPase activity; ISS:SGD.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0008094; F:DNA-dependent ATPase activity; IBA:GO_Central.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006312; P:mitotic recombination; IMP:SGD.
DR   GO; GO:0044030; P:regulation of DNA methylation; IBA:GO_Central.
DR   Gene3D; 3.40.50.10810; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Coiled coil; Complete proteome; DNA-binding; Helicase;
KW   Hydrolase; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN         1    853       Uncharacterized ATP-dependent helicase
FT                                IRC5.
FT                                /FTId=PRO_0000074385.
FT   DOMAIN      234    401       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      607    758       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     247    254       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COILED      548    580       {ECO:0000255}.
FT   MOTIF       352    355       DEGH box.
FT   COMPBIAS     41     91       Asp-rich.
SQ   SEQUENCE   853 AA;  96966 MW;  91EF0E200197FF28 CRC64;
     MSRCSNAALM TVVEDAVGAR VAARTRNMSN GVNYREKEVN DLTADISDSD SDLDSEDNKH
     GKGDNDTAPI WLQDDVHSDE DIQLDSEDDS DTEAVQAQVV DKLAKDTKSE QKSLDDELSE
     MDTKTVSLKL KKLNEFVRQS QVYSSIIADT LLHRSNEVAN ANTKDNSNSD DEEHSSKKRK
     TKKKSITDFF KKQKKNEDTT TQNGAPDDAA IKQPRLLKNC ILKPYQLEGL NWLITLYENG
     LNGILADEMG LGKTVQSIAL LAFIYEMDTK GPFLVTAPLS TLDNWMNEFA KFAPDLPVLK
     YYGTNGYKER SAKLKNFFKQ HGGTGIVITS YEIILRDTDL IMSQNWKFLI VDEGHRLKNI
     NCRLIKELKK INTSNRLLLT GTPLQNNLAE LWSLLNFIMP DIFADFEIFN KWFDFDSLNL
     GSGSNSEALN KLINDELQKN LISNLHTILK PFLLRRLKKV VLANILPPKR EYIINCPMTS
     AQEKFYKAGL NGKLKKTMFK ELIKDFFTLN DEYIGHVSNR SIRDFINYKL SGNETSNTDN
     KINPTLLQMD KLYKKNLQME ISNKKLQNMM MQLRQIIDST FLFYFPYLHP EDLTLETLLK
     TSGKLQILQK LIPPLISEGH KVLIYSQFVN MLDLIEDWCD LNSFATFRID GSVNNETRKD
     QLEKFNSSKD KHNIFLLSTR AAGLGINLVG ADTVVLFDSD WNPQVDLQAM DRCHRIGQES
     PVIVYRLCCD NTIEHVILTR AANKRNLERM VIQMGKFNNL KKLALNEGSF LKANKAGVNV
     TNKDLVQELS MLLMSDESNI GFENGGQKEN KATEGQLTDK EVEELTNRSL EAYKANRVVD
     LPHVKLFETT SGL
//
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