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Database: UniProt
Entry: P43874
LinkDB: P43874
Original site: P43874 
ID   BCCP_HAEIN              Reviewed;         155 AA.
AC   P43874;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   10-APR-2019, entry version 106.
DE   RecName: Full=Biotin carboxyl carrier protein of acetyl-CoA carboxylase;
DE            Short=BCCP;
GN   Name=accB; Synonyms=fabE; OrderedLocusNames=HI_0971;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA   Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA   Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA   Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA   Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA   Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-10.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(SICI)1522-2683(20000101)21:2<411::AID-ELPS411>3.0.CO;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B.,
RA   Gray C., Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: This protein is a component of the acetyl coenzyme A
CC       carboxylase complex; first, biotin carboxylase catalyzes the
CC       carboxylation of the carrier protein and then the transcarboxylase
CC       transfers the carboxyl group to form malonyl-CoA. {ECO:0000250}.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
DR   EMBL; L42023; AAC22631.1; -; Genomic_DNA.
DR   PIR; E64105; E64105.
DR   RefSeq; NP_439132.1; NC_000907.1.
DR   RefSeq; WP_005693317.1; NC_000907.1.
DR   ProteinModelPortal; P43874; -.
DR   SMR; P43874; -.
DR   STRING; 71421.HI_0971; -.
DR   PRIDE; P43874; -.
DR   EnsemblBacteria; AAC22631; AAC22631; HI_0971.
DR   GeneID; 949974; -.
DR   KEGG; hin:HI0971; -.
DR   PATRIC; fig|71421.8.peg.1012; -.
DR   eggNOG; ENOG4105KM4; Bacteria.
DR   eggNOG; COG0511; LUCA.
DR   KO; K02160; -.
DR   OMA; IKSPIIG; -.
DR   PhylomeDB; P43874; -.
DR   BioCyc; HINF71421:G1GJ1-1012-MONOMER; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro.
DR   GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR001249; AcCoA_biotinCC.
DR   InterPro; IPR001882; Biotin_BS.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   PRINTS; PR01071; ACOABIOTINCC.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   TIGRFAMs; TIGR00531; BCCP; 1.
DR   PROSITE; PS00188; BIOTIN; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
PE   1: Evidence at protein level;
KW   Biotin; Complete proteome; Direct protein sequencing;
KW   Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN         1    155       Biotin carboxyl carrier protein of
FT                                acetyl-CoA carboxylase.
FT                                /FTId=PRO_0000146808.
FT   DOMAIN       72    155       Biotinyl-binding. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01066}.
FT   MOD_RES     121    121       N6-biotinyllysine. {ECO:0000250,
FT                                ECO:0000255|PROSITE-ProRule:PRU01066}.
SQ   SEQUENCE   155 AA;  16247 MW;  696F19B4429A03CD CRC64;
     MDIRKIKKLI ELVEESGITE LEVQEEEGTV RISRAAPVIA PAAVQYAAAP VVAPTPAAAP
     AQVPAAATTA PAASDELSGH LVRSPMVGTF YRSPSPEAKA FVEVGQSVKV GDALCIVEAM
     KMMNRIEADK AGVVKAILIN DGNAVEFDEP LIVIE
//
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