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Database: UniProt
Entry: P44501
LinkDB: P44501
Original site: P44501 
ID   DDH_HAEIN               Reviewed;         331 AA.
AC   P44501;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   07-NOV-2018, entry version 111.
DE   RecName: Full=2-hydroxyacid dehydrogenase homolog;
DE            EC=1.1.1.-;
GN   Name=ddh; OrderedLocusNames=HI_0085;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA   Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA   Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA   Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA   Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA   Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; L42023; AAC21763.1; -; Genomic_DNA.
DR   PIR; F64047; F64047.
DR   RefSeq; NP_438258.1; NC_000907.1.
DR   RefSeq; WP_005693834.1; NC_000907.1.
DR   ProteinModelPortal; P44501; -.
DR   SMR; P44501; -.
DR   STRING; 71421.HI0085; -.
DR   PRIDE; P44501; -.
DR   EnsemblBacteria; AAC21763; AAC21763; HI_0085.
DR   GeneID; 950977; -.
DR   KEGG; hin:HI0085; -.
DR   PATRIC; fig|71421.8.peg.86; -.
DR   eggNOG; ENOG4105C5I; Bacteria.
DR   eggNOG; COG1052; LUCA.
DR   KO; K03778; -.
DR   OMA; THKAYNR; -.
DR   PhylomeDB; P44501; -.
DR   BioCyc; HINF71421:G1GJ1-86-MONOMER; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0008720; F:D-lactate dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN         1    331       2-hydroxyacid dehydrogenase homolog.
FT                                /FTId=PRO_0000076021.
FT   NP_BIND     154    155       NAD. {ECO:0000250}.
FT   NP_BIND     232    234       NAD. {ECO:0000250}.
FT   NP_BIND     295    298       NAD. {ECO:0000250}.
FT   ACT_SITE    234    234       {ECO:0000250}.
FT   ACT_SITE    263    263       {ECO:0000250}.
FT   ACT_SITE    295    295       Proton donor. {ECO:0000250}.
FT   BINDING     258    258       NAD. {ECO:0000250}.
SQ   SEQUENCE   331 AA;  37088 MW;  AB13300E94962566 CRC64;
     MKIAIYSTKS YDRKYIELIN AKYNFDLEFF DFMLNESTVR LAEHCEVVCI FVNDNGSRKV
     LEKLAALGVK IVALRCAGFN NVDLKAAQEL GIQVVRVPAY SPEAVAEHTI GLMMTLNRRI
     HRAYQRTREA NFSLEGLIGF NMYGRTVGVI GTGKIGIAVM RILKGFGMNI LAYDPFKNPV
     VEELGGQYVE LDELYAKSHV ITLHCPATPE NYHLLNCEAF AKMKDGVMIV NTSRGSLIDT
     QAAIDALKQR KIGALGMDVY ENERDLFFED KSNEVIQDDI FRRLSSCHNV LLTGHQAFLT
     EEALTNIADV TLSNIYKLKS GKVCENIVLP S
//
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