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Database: UniProt
Entry: P44653
LinkDB: P44653
Original site: P44653 
ID   NAPH_HAEIN              Reviewed;         287 AA.
AC   P44653;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   10-APR-2019, entry version 116.
DE   RecName: Full=Ferredoxin-type protein NapH {ECO:0000250|UniProtKB:P33934};
GN   Name=napH; OrderedLocusNames=HI_0346;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA   Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA   Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA   Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA   Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA   Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Required for electron transfer from ubiquinol, via NapC,
CC       to the periplasmic nitrate reductase NapAB complex.
CC       {ECO:0000250|UniProtKB:P33934}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00711};
CC       Note=Binds 2 [4Fe-4S] cluster. {ECO:0000255|PROSITE-
CC       ProRule:PRU00711};
CC   -!- SUBUNIT: Interacts with NapC. {ECO:0000250|UniProtKB:P33934}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P33934}; Multi-pass membrane protein
CC       {ECO:0000255}.
DR   EMBL; L42023; AAC22007.1; -; Genomic_DNA.
DR   PIR; B64149; B64149.
DR   RefSeq; NP_438510.1; NC_000907.1.
DR   RefSeq; WP_005694327.1; NC_000907.1.
DR   ProteinModelPortal; P44653; -.
DR   STRING; 71421.HI_0346; -.
DR   EnsemblBacteria; AAC22007; AAC22007; HI_0346.
DR   GeneID; 949454; -.
DR   KEGG; hin:HI0346; -.
DR   PATRIC; fig|71421.8.peg.365; -.
DR   eggNOG; ENOG4105GXZ; Bacteria.
DR   eggNOG; COG0348; LUCA.
DR   KO; K02574; -.
DR   OMA; CPVGAFY; -.
DR   PhylomeDB; P44653; -.
DR   BioCyc; HINF71421:G1GJ1-362-MONOMER; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation-reduction process; IEA:UniProtKB-KW.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR011886; NapH_MauN.
DR   Pfam; PF12801; Fer4_5; 2.
DR   Pfam; PF12837; Fer4_6; 1.
DR   TIGRFAMs; TIGR02163; napH_; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   3: Inferred from homology;
KW   4Fe-4S; Cell inner membrane; Cell membrane; Complete proteome;
KW   Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    287       Ferredoxin-type protein NapH.
FT                                /FTId=PRO_0000159284.
FT   TOPO_DOM      1     29       Cytoplasmic.
FT                                {ECO:0000250|UniProtKB:P33934}.
FT   TRANSMEM     30     50       Helical. {ECO:0000255}.
FT   TOPO_DOM     51     79       Periplasmic.
FT                                {ECO:0000250|UniProtKB:P33934}.
FT   TRANSMEM     80    100       Helical. {ECO:0000255}.
FT   TOPO_DOM    101    139       Cytoplasmic.
FT                                {ECO:0000250|UniProtKB:P33934}.
FT   TRANSMEM    140    160       Helical. {ECO:0000255}.
FT   TOPO_DOM    161    170       Periplasmic.
FT                                {ECO:0000250|UniProtKB:P33934}.
FT   TRANSMEM    171    191       Helical. {ECO:0000255}.
FT   TOPO_DOM    192    287       Cytoplasmic.
FT                                {ECO:0000250|UniProtKB:P33934}.
FT   DOMAIN      217    247       4Fe-4S ferredoxin-type 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   DOMAIN      252    281       4Fe-4S ferredoxin-type 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL       226    226       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL       229    229       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL       232    232       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL       236    236       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL       261    261       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL       264    264       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL       267    267       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL       271    271       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
SQ   SEQUENCE   287 AA;  31753 MW;  D2E20FC4E3C3C197 CRC64;
     MANAPKFAGK ESREKWGWWY ANRFLFWRRL SQLSILAMFL SGPYFGVWIL KGNYSGSLLL
     DTIPLSDPLI TAESLAARHL PDALTLIGAA IIVLFYAVLG SKVFCGWVCP LNVVTDCAAW
     LRRKLGIRQT AKISRGLRYG ILVLILLGSS VSGMLLWEWV NPVAALGRAF VFGFGATGWL
     LLVIFLFDLL IAEHGWCGHL CPIGAAYGVI GAKSLIRIKV IDRAKCDNCM DCYNVCPEAQ
     VLRSPLHGKK DESLLVLSKD CISCGRCIDV CAEKVFKFST RFDHSGE
//
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