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Database: UniProt
Entry: P45018
LinkDB: P45018
Original site: P45018 
ID   HRPA_HAEIN              Reviewed;        1304 AA.
AC   P45018; P44108; P44109; P71368;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   16-OCT-2019, entry version 129.
DE   RecName: Full=ATP-dependent RNA helicase HrpA homolog;
DE            EC=3.6.4.13;
GN   Name=hrpA; OrderedLocusNames=HI_1070;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA   Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA   Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA   Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA   Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA   Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION.
RA   White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D.;
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily. {ECO:0000305}.
DR   EMBL; L42023; AAC22728.1; -; Genomic_DNA.
DR   PIR; G64165; G64165.
DR   PIR; I64019; I64019.
DR   RefSeq; NP_439228.2; NC_000907.1.
DR   SMR; P45018; -.
DR   STRING; 71421.HI_1070; -.
DR   PRIDE; P45018; -.
DR   EnsemblBacteria; AAC22728; AAC22728; HI_1070.
DR   GeneID; 950050; -.
DR   KEGG; hin:HI1070; -.
DR   PATRIC; fig|71421.8.peg.1114; -.
DR   eggNOG; ENOG4105CQ7; Bacteria.
DR   eggNOG; COG1643; LUCA.
DR   KO; K03578; -.
DR   OMA; YIKLMTD; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006397; P:mRNA processing; IBA:GO_Central.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR024590; HrpA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010222; RNA_helicase_HrpA.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF11898; DUF3418; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01967; DEAH_box_HrpA; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN         1   1304       ATP-dependent RNA helicase HrpA homolog.
FT                                /FTId=PRO_0000055179.
FT   DOMAIN       93    257       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      281    448       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     106    113       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       203    206       DEAH box.
SQ   SEQUENCE   1304 AA;  149626 MW;  179B59B57FBA5867 CRC64;
     MKNSSVKHTL TPLQQSLFSQ LNDIMLVDQR RLSARIHGIG KIKSQEAQQA VAAEIQQQIE
     QARLRVEQRK SAVQNPIVFP ESLPVSQRKV EIQKLISEHQ VIVVAGETGS GKTTQLPKMC
     LELGFGNLGM IGHTQPRRIA ARSVAARIAE ELETELGGLV GYKVRFNDQI SDNTQIKLMT
     DGILLAEIQN DRFLNQYSCL IIDEAHERSL NNDFILGYLK QLLPRRRRDL KLIITSATID
     VERFSKHFNN APIIEVSGRT YPVEVRYRPV VEEDDQDQLQ GILNAVDELQ AEGRGDILIF
     MNGEREIRDT AEALQKQNLK HTEILPLFAR LSAQEQNKIF HPSGLNRIVL ATNVAETSLT
     VPSIKYVIDP GTARISRYSY RTKVQRLPIE PISQASANQR KGRCGRVSEG ICIRLYSEED
     FNSRPEFTDP EILRTNLASV ILQMTALGLD DIEAFPFVDA PDERHIQDGV KLLEELGAFE
     TVQTKSGEKR LLTRVGRQLA QLPVDPRLAK MILSAVNFGC VYEMMIIVSA LSIQDPRERP
     QEKQQASDEK HRRFADKKSD FLAFLNLWRY LQEQQKESSK NQFRRQCQKD FLNYLRIREW
     QDIYHQIRLT VREMSLPINS EKAEYQQIHT ALLSGLLSHI GLKEAEKQQY LGARNAHFAI
     FPNSVLFKKQ PKWVMAAELV ETSKLWGRMV AEIEPEWIEP LAEHLIKKSY SVPLWSKSRG
     AVIADEKVTL YGVPIVAVRP VNYGAIDPTV SREIFIQSAL VEGGWNTKHK FFKENQRLVR
     EVEELEHKSR RRDILVDDRT LFEFYDQRIG TEVVSQKHFD TWWKKAQQKD PELLNFEHSF
     LINDDAEQVS KLDFPNFWHQ GNLKLKLTYQ FEPGTDADGV TVHIPLPLLN QVEMTGFDWQ
     IPGLREELVI ALIKSLPKSY RRNFVPAPNY AQAFLSRAVP LEKPLLDTLI YELRRMTGVT
     VEAEHWNWEQ IPSHLKMTFR VVDENGKKIA ESMNLDELKF NLKDRVQESI SAVADDGIEQ
     SGLHIWSFAD LPQCYEQKQR GFSVKAFPAI VDEKDAVGIK LFETEFEQSV AMQQGLRRLL
     LLNVPSPIKY LHEKLPNKAK LGLYFTPFGR VLDLIDDCIA CAVDKLIADF GGFVWDEAGF
     EKLRDFVREN LNEVTVDIAQ KVEQILTLTY QLNQRLKGKM DFTMAFALSD IKSQLAGLVY
     QGFVQKSGYD RLPDLQRYLQ AVDKRIDKLA QDVNRDRAAM LRVEQVQQAY QQLLAKLPKS
     KPISDEVAEI RYMIEELRVS LFAQQLGTKY QISDKRIGNI ISQY
//
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