GenomeNet

Database: UniProt
Entry: P45250
LinkDB: P45250
Original site: P45250 
ID   Y1556_HAEIN             Reviewed;         315 AA.
AC   P45250;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   28-FEB-2018, entry version 111.
DE   RecName: Full=Putative 2-hydroxyacid dehydrogenase HI_1556;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=HI_1556;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA   Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA   Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA   Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA   Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA   Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(SICI)1522-2683(20000101)21:2<411::AID-ELPS411>3.0.CO;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B.,
RA   Gray C., Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; L42023; AAC23205.1; -; Genomic_DNA.
DR   PIR; F64129; F64129.
DR   RefSeq; NP_439705.1; NC_000907.1.
DR   RefSeq; WP_005693583.1; NC_000907.1.
DR   ProteinModelPortal; P45250; -.
DR   SMR; P45250; -.
DR   STRING; 71421.HI1556; -.
DR   EnsemblBacteria; AAC23205; AAC23205; HI_1556.
DR   GeneID; 950416; -.
DR   KEGG; hin:HI1556; -.
DR   PATRIC; fig|71421.8.peg.1627; -.
DR   eggNOG; ENOG4105C5I; Bacteria.
DR   eggNOG; COG1052; LUCA.
DR   KO; K00018; -.
DR   OMA; PHIAWAY; -.
DR   PhylomeDB; P45250; -.
DR   BioCyc; HINF71421:G1GJ1-1576-MONOMER; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN         1    315       Putative 2-hydroxyacid dehydrogenase
FT                                HI_1556.
FT                                /FTId=PRO_0000076034.
FT   NP_BIND     156    157       NAD. {ECO:0000250}.
FT   NP_BIND     231    233       NAD. {ECO:0000250}.
FT   NP_BIND     285    288       NAD. {ECO:0000250}.
FT   ACT_SITE    233    233       {ECO:0000250}.
FT   ACT_SITE    262    262       {ECO:0000250}.
FT   ACT_SITE    285    285       Proton donor. {ECO:0000250}.
FT   BINDING      73     73       NAD. {ECO:0000250}.
FT   BINDING     257    257       NAD. {ECO:0000250}.
SQ   SEQUENCE   315 AA;  34636 MW;  0023D28C3266689B CRC64;
     MKIVFLDSTA IPKHISIPRP SFEHTWTEYE HTSAEQTIER VKDADIVITS KVIFDRETLQ
     QLPKLKLIAI TATGTNNVDL VAAEEMGIAV RNVTGYSSTT VPEHVIGLIF SLKHSLAGWL
     RDQTEAKWAE SKQFCYFDYP ITDVRGSTLG VFGKGCLGTE VGRLANAVGM KVLYAEHKDA
     TVCREGYTPF DEVLKQADIV TLHCPLTETT KDLINAETLS KMKKGAFLIN TGRGPLIDEL
     ALVDALKTGH LGGAALDVMV KEPPEKDNPL ILAAKTMPNL IITPHIAWAS DSAVTTLVGK
     VMQNIEEFVQ QLHQK
//
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